OBESITY

This study is testing whether a minimally invasive stomach-reducing procedure can help obese patients with ulcerative colitis lose weight before they undergo major colon removal surgery. Researchers want to see if this approach is safe and effective for this specific group of pat…

This study is testing whether an investigational injection called HDM1005 can help adults with obesity lose weight. About 240 participants without diabetes will receive either the injection or a placebo for 22 weeks to see how much weight they lose and to check for side effects. …

This study is testing a 3-week diet and exercise program for American Indian adults with obesity-related cancers who are scheduled for surgery. The program includes eating walnuts, walking daily, and supervised exercise sessions to see if it's practical for patients and if it can…

This study is testing if a virtual weight management program can help people with severe obesity and advanced kidney disease lose enough weight to qualify for a lifesaving kidney transplant. Participants will either join the program, which includes coaching and a weight-loss medi…

This is the first study in humans testing a new oral medication called BMF-650 for weight management. Researchers will give the drug to 80 otherwise healthy overweight or obese adults to check if it's safe and how the body processes it. The study will also measure early effects o…

This study looks back at medical records to compare two weight loss methods for people with obesity who stopped taking GLP-1 medications (like Wegovy or Zepbound) because of side effects or because the drugs didn't work well enough. It compares an endoscopic procedure that stitch…

This study is testing two new investigational drugs, macupatide and eloralintide, to see if they help with weight loss in adults who have type 2 diabetes and are overweight or have obesity. About 200 participants will receive the drugs alone, in combination, or a placebo for near…

This study is testing whether a new weekly injection called HM15275 can help adults with obesity or overweight lose weight and is safe to use. About 250 participants without diabetes will receive either the drug or a placebo (inactive shot) for 36 weeks to compare results. The ma…

This study is testing if adding the antibiotic minocycline to standard antidepressants is a practical and acceptable approach for people who have both obesity and depression that hasn't responded to other treatments. Researchers want to see if participants can complete the 8-week…

This early-stage study is testing a new drug called ARO-INHBE for adults with obesity, including some who also have type 2 diabetes. Researchers want to see if the drug is safe and how it affects the body, particularly when taken alongside another weight-loss medication. The stud…

This study is testing whether a specialized care program helps people with obesity feel more confident in managing their health. About 133 adults with obesity will follow a 6-month program focused on education and support. Researchers will measure changes in participants' self-co…

This study is testing whether exercising before breakfast (fasted) is better for heart health and weight loss than exercising after eating. Researchers will compare the two approaches over a 16-week supervised exercise program with 40 adults who have overweight or obesity. They w…

This study is testing several different weight management treatments for adults with obesity or overweight. The trial will evaluate how safe and effective these new interventions are for long-term weight control. Participants will be assigned to different treatment groups based o…

This study is testing a new digital tool called P3-EX, designed to help doctors create personalized exercise plans for their patients. The researchers want to see if the tool is easy for doctors to use and if patients find it helpful. They will also check if using the tool leads …

This study is testing a new, single-port robotic system for performing weight loss (bariatric) surgery. It aims to see if this robotic approach is safe and effective for helping patients lose weight and improve related health measures like blood pressure and blood sugar. The stud…

This study aims to see if adding exercise to a healthy Mediterranean diet is better than diet alone for reducing body-wide inflammation in adults with obesity and non-alcoholic fatty liver disease (NAFLD). Researchers will compare two different exercise programs—outdoor walking a…

This is the first study in humans testing a new injection called DA-1726 for obesity. Researchers want to see if it's safe and how the body handles it in adults who are otherwise healthy but have obesity. The study will measure side effects and look at early signs of how it might…

This early-stage study aims to understand how the body absorbs a new weight management medicine when it's injected into different areas, like the thigh, arm, or abdomen. It will involve 54 adults who are overweight or have obesity, who will receive a single dose. Researchers will…

This is an early-stage study to test the safety and effects of an investigational drug called ABBV-295, given as an injection under the skin, in adults with obesity. The main goals are to check for side effects, see how the body processes the drug, and measure any changes in body…

This study is testing whether drinking a beverage rich in a specific type of milk fat (milk polar lipids) daily for 8 weeks can improve heart health markers. Researchers will enroll 130 adults with high cholesterol and abdominal obesity to see if the drink lowers 'bad' LDL choles…

This study is testing if a weekly injection called semaglutide can help adults who are quitting smoking avoid gaining weight. Researchers want to see if the medication helps control appetite and food intake during the challenging period after stopping cigarettes. The trial will e…

This study is testing whether using smartphone apps can help people with type 2 diabetes better manage their weight and blood sugar levels. Over six months, participants will track their daily weight and blood glucose using an app, comparing it to a standard program. The goal is …

This study is testing whether taking the weight-loss medication semaglutide for 12 weeks before IVF treatment improves embryo quality in overweight and obese women. Researchers want to see if this pre-treatment leads to more high-quality embryos compared to standard IVF without t…

This study is testing whether adding a low dose of a thyroid medication (levothyroxine) to a structured diet and exercise plan helps adults with obesity lose more weight and prevent regain. The trial will include 286 adults with obesity who have slightly higher-than-average thyro…

This study is testing whether an 8-session nutrition education program is practical and helpful for people with diabetes or prediabetes. The program teaches participants how to eat more fiber-rich foods like fruits, vegetables, and whole grains. Researchers will enroll 48 people …

This study is testing whether a weekly injection called tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity lose weight and improve related health conditions like high blood pressure and prediabetes. About 300 teens aged 12-17 with obesity and a…

This study is testing a new weekly injection called MET097 to help adults with type 2 diabetes and overweight or obesity lose weight and better control their blood sugar. About 1,000 participants will receive either the real injection or a placebo (a shot with no medicine) for ab…

This study is testing if a weekly weight-loss medication called Tirzepatide can help people with obesity and a heart rhythm disorder called atrial fibrillation. About 100 participants will receive either Tirzepatide or a placebo for 12 months to see if losing weight leads to bett…

This study is testing whether providing free boxes of fruits and vegetables, along with nutrition education, can help improve health for people at risk for diabetes and heart disease in the Mississippi Delta. About 300 participants from local health clinics will be randomly assig…

This study is testing whether a new weekly injection called eloralintide helps people with obesity or overweight lose more weight when added to their current weekly weight-loss medication. It will involve about 900 adults, some with type 2 diabetes and some without, over roughly …

This study is testing whether a weekly injection called tirzepatide, combined with a reduced-calorie diet and more physical activity, helps people with obesity or overweight lose weight and improve related health conditions. It involves over 2,500 adults who do not have type 2 di…

This study is testing a new digital tool called PREVENT, designed to help doctors in rural clinics provide better diet and exercise counseling to patients with obesity. The tool displays patient health information to guide conversations and set personalized goals. Researchers wil…

This study is testing if the timing of daily eating affects blood sugar control. Researchers are comparing three different 9-hour eating windows in 120 adults with obesity who have type 2 diabetes or are at risk for it. The goal is to see if starting meals earlier or later in the…

This study is testing if eating special protein and fiber bars helps people lose weight and improve their joint and heart health. 144 adults with overweight or obesity will follow a low-calorie diet for 12 weeks, with some groups adding these bars to their meals. Researchers will…

This study is testing how well the Mayo Clinic Diet works for helping people lose a significant amount of weight (more than 5%) and keep it off for up to a year, compared to their usual routine. Researchers will follow 250 adults with a body mass index (BMI) of 25 or higher. They…

This study aims to see if popular GLP-1 weight-loss medications, when taken with or without a supervised exercise program, help people with obesity keep their muscle mass and physical strength while losing weight. It will also look at what happens to muscle and metabolism when pe…

This study is testing whether a form of vitamin B3 called nicotinamide can stop or even reverse liver scarring (fibrosis) in people with fatty liver disease. About 30 overweight or obese adults will take either nicotinamide or a placebo pill daily for one year. Researchers will u…

This study compares two ways to strengthen the staple line during weight-loss sleeve surgery. One method uses medical glue, while the other uses a piece of the patient's own abdominal tissue. Researchers want to see which approach better prevents complications like bleeding, leak…

This large, 5-year study is testing how well the weekly medication tirzepatide works for weight loss in a real-world setting compared to standard care. It will involve 3000 adults with obesity who do not have diabetes, aiming to see how much weight they lose and if the drug helps…

This study is testing whether two weight loss medications, alone or combined, can help people who have started to regain weight after bariatric surgery. About 120 adults who had surgery at least 18 months ago and regained at least 5% of their lost weight will receive either the m…

This study is testing a new weekly injection called XW003 in Chinese teenagers with obesity. The main goal is to see if the injection is safe and how the body handles it. Researchers will also check if it helps with weight loss compared to a placebo (a dummy treatment with no med…

This study is testing a 12-week lifestyle program designed for Black women who are breast cancer survivors and have high blood pressure and obesity. The program provides grocery delivery, cooking classes, and nutrition education to see if it helps participants eat healthier and b…

This study is testing a new oral drug called MKP10241 in adults with obesity, some of whom also have type 2 diabetes. The main goals are to see if the drug is safe, how the body processes it, and if eating food changes its effects. Researchers will compare the drug to a placebo (…

This study is testing whether a new medication called aleniglipron is safe and helps with weight loss and blood sugar control in adults with type 2 diabetes who are overweight or have obesity. About 50 participants will take either the drug or a placebo (inactive pill) daily for …

This study is testing a new weekly injection called KAI-9531 to see if it helps people with obesity lose more weight than a current medication (semaglutide) or a placebo (inactive shot). It will involve about 1200 adults who do not have diabetes. The main goal is to see which tre…

This study is testing whether a ketogenic (keto) diet helps people maintain weight loss better than a low-fat diet. Researchers want to see if the keto diet helps the body burn more calories and reduces hunger after weight loss. The study involves 20 adults with obesity who will …

This study is testing a new drug, RO7204239, to see if it can help the body use insulin more effectively in people with type 2 diabetes who are also overweight or have obesity. It will compare the drug against a placebo (a dummy treatment) in 30 participants over 24 weeks. Resear…

This study is testing whether time-restricted eating—limiting all daily food intake to a 9-hour window—can improve heart and metabolic health in people with obesity and prediabetes. It will involve 100 participants who will follow this eating pattern for 12 weeks without trying t…

This study is testing whether a diet that replaces some animal protein (like meat and dairy) with plant protein (like beans and nuts) can help people with type 2 diabetes manage their blood sugar levels better than a standard diabetes diet. About 146 overweight or obese adults wi…

This study is testing a new weekly injection called eloralintide to see if it helps adults with obesity and type 2 diabetes lose weight. Over 1,000 participants will receive either the real injection or a placebo (dummy shot) for about 75 weeks. Researchers will measure changes i…

This study is testing if simple, at-home strategies can reduce the health risks linked to too much evening screen time. Researchers are recruiting 30 adults at risk for heart disease and diabetes to try strategies like avoiding food after 8 PM, blocking blue light, and breaking u…

This is the first study in people to test a new drug called MBX 4291 for obesity. Researchers will give the drug as an injection under the skin to 64 adults with obesity to check if it is safe and how the body handles it. The main goal is to see what side effects people experienc…

This study is testing a once-daily oral medication called orforglipron to see if it helps adolescents with obesity or overweight with related health conditions manage their weight. It will compare the drug to a placebo (a pill with no medicine) in about 125 participants over 18 m…

This study is testing a new drug called ALN-2232 to see if it is safe and helps people with obesity lose weight. Researchers will give it to participants by itself and also in combination with an existing weight-loss medication, tirzepatide. The main goals are to check for side e…

This study is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight and type 2 diabetes lose weight and better control their blood sugar. It will compare the pill's effects to a placebo (a dummy pill) in about 600 participants over 18 …

This study is testing whether a dietary supplement made from omega-3 fatty acids can help reduce harmful inflammation in blood vessels. It will involve 50 adults in France who have both obesity and high blood pressure, conditions that increase heart disease risk. Researchers want…

This study is testing whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain their muscle mass and strength when they start taking certain weight-loss medications (like Ozempic or Mounjaro). The goal is to see if…

This study aims to find the most effective telehealth approach to help older adults with obesity and multiple chronic conditions lose weight. Researchers will test two different weight loss programs—one focused on medical guidance and one focused on behavior coaching—and adjust t…

This study is testing whether a simple, 8-week breathing exercise program can improve brain blood flow and reduce harmful inflammation in otherwise healthy adults with obesity. Researchers will enroll 30 participants to use a special breathing device for a few minutes daily, meas…

This study is testing if adding a simple surgical step called omentopexy during sleeve gastrectomy (a common weight-loss surgery) can prevent patients from developing new, long-term acid reflux disease. Researchers will compare two groups of over 500 obese patients for two years:…

This study is testing whether a structured meal replacement program can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower their blood sugar. Researchers will provide participants with a low-calorie nutrition plan and track their weight, bl…

This study is testing whether a new drug called UBT251 is safe and helps people with overweight or obesity manage their weight. About 333 participants will be randomly assigned to receive either the actual drug or a placebo (inactive substance) for comparison. Researchers will me…

This study is testing if changing gut bacteria with a short course of antibiotics can help people keep weight off after successful dieting. Researchers will enroll 200 adults with obesity who first complete a personalized weight loss program. Participants will then receive either…

This study is testing a new, intensive lifestyle program designed for young women aged 18-25 who have a body mass index (BMI) between 25 and 50. It will compare this new program to a standard behavioral weight loss program over 12 months. The main goals are to see which approach …

This study aims to find out if a very intensive, 2-year weight loss program works as well as bariatric surgery for adults with severe obesity. The program includes meal replacements, behavioral coaching, and weight-loss medications. The results will help guide future treatment op…

This study is testing whether changing when night shift nurses eat can improve their health. It will compare three approaches: just tracking food, limiting eating to a 10-hour daytime window, or that same window plus a special snack during the night shift. The goal is to see if t…

This study is testing a weight loss program designed for taxi and ride-share drivers in New York City. It will compare four different support methods—like personal counseling, text messages, and weekly calls—to see which combination works best to help drivers lose at least 5% of …

This study is testing if adding lifestyle changes to standard sleep apnea treatment can better control eye pressure in glaucoma. It will involve 40 obese adults who have both glaucoma and sleep apnea. One group will use a CPAP machine nightly, while the other will also follow a l…

This study is testing a new oral drug, ACM-001.1, to see if it can help people with obesity keep their muscle while they lose weight using the medication semaglutide. It will involve about 120 participants and has two parts: one where the new drug is taken alongside semaglutide, …

This is an early-stage study to test the safety and how the body processes a new drug called TLC 6740. It will first be given to healthy volunteers to check for side effects. Later, it will be tested in people with obesity, some of whom also have type 2 diabetes, to see if it mig…

This study follows people for 10 years after they had a specific type of weight loss surgery called omega gastric bypass. Researchers want to see if one version of the surgery (with a 150cm loop) is safer than another (with a 200cm loop) over the long term. They are looking at se…

This study aims to see if a specific probiotic (LC-19) can help with weight loss and improve metabolism as effectively as the medication semaglutide. It will involve 140 adults, most of whom are overweight or obese, who will follow a diet and lifestyle plan while also taking eith…

This small, early-stage study is exploring whether attapulgite, a type of clay, is safe and can help people with obesity manage their weight. It will enroll 40 adults with obesity, some of whom also have type 2 diabetes, to see if the treatment affects body measurements, blood su…

This study is testing whether a specific combination of probiotic supplements can help adults with obesity manage their weight and food-related behaviors. Researchers will compare the probiotic against a placebo (a dummy pill) in 100 participants, while everyone also follows stan…

This study aims to find the best weight loss medication for people with bipolar disorder by first identifying their specific eating patterns, like 'emotional hunger' or 'hungry gut.' Researchers will match 100 participants to one of three FDA-approved weight loss drugs or a no-me…

This study is testing whether a daily pill called orforglipron helps people with obesity or overweight lose weight. It will involve about 600 adults who have not succeeded with diet alone and have at least one other weight-related health issue. The study will compare the pill's e…

This study is testing whether a new drug called maridebart cafraglutide can help control obstructive sleep apnea and reduce weight in adults who are overweight or obese and already use a CPAP machine. It will compare the drug to a placebo over one year to see if it reduces breath…

This large study is testing whether a new injectable medication, maridebart cafraglutide, can help prevent serious heart problems in people who already have heart disease and are overweight or obese. It will compare the drug to a placebo (inactive shot) in over 12,000 participant…

This study aims to compare two major weight loss treatments—new injectable medications (like Ozempic or Mounjaro) and gastric bypass surgery—to see how they differently affect the body. Researchers will follow 60 adults with severe obesity for one year, using body scans to measur…

This study is testing a new weekly injection called LY3437943 (retatrutide) to see if it helps adults with obesity or overweight lose weight. About 300 participants will receive either the drug or a placebo (dummy injection) for 48 weeks, along with diet and exercise advice. The …

This study is testing two different endoscopic procedures that use stitches to make the stomach smaller, helping with weight loss. It's for adults with obesity who haven't succeeded with diet and exercise alone. Researchers will compare the safety and effectiveness of the new End…

This study is testing whether a comprehensive, 2-year weight loss program works better than standard care for adults with severe obesity and related health problems. The intensive program includes meal replacements, behavioral coaching, and weight-loss medication, and is compared…

This study is testing two new weekly injection drugs, CagriSema and cagrilintide, to see how well they help children and adolescents with overweight or obesity manage their weight. About 460 participants, aged 8 to 18, will receive either one of the new drugs, an existing drug (s…

This study is testing if GLP-1 receptor agonist drugs (like Ozempic or Wegovy) can help control chronic kidney disease by improving unhealthy fat tissue. Researchers will enroll 250 adults with kidney disease who also have type 2 diabetes, obesity, or heart disease. The main goal…

This study is testing if a simple saliva test can identify which people with obesity are most likely to respond well to the weight loss medication semaglutide. Researchers will compare weight loss in people who test positive or negative on the saliva test while taking the drug or…

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This is an early-stage study to check the safety and how the body processes a new nasal spray version of a weight loss medication called semaglutide. It will involve 60 overweight or obese adults who will receive a single dose. The main goal is to see how safe the spray is and ho…

This study is testing if using two investigational drugs together—tirzepatide and bimagrumab—alongside a lifestyle program leads to better body composition changes than either drug alone in adults with obesity. The goal is to see if the combination helps people lose more fat whil…

This study is testing whether a new weekly injection called retatrutide is safe and effective for weight loss. It will involve about 250 adults who have obesity or are overweight but do not have type 2 diabetes. Participants will receive either the real injection or a placebo (a …

This study is testing if two existing medications, mirabegron and tadalafil, can help reverse prediabetes in obese adults. Researchers will give 96 participants either one drug, both drugs, or a placebo for 14 weeks to see if their blood sugar control improves. The goal is to see…

This study aims to understand why teens and young adults respond differently to weight loss surgery and to see if adding the medication semaglutide can help those who don't lose enough weight after surgery. It will enroll 40 people aged 12-24. Researchers will first observe body …

This study is testing a weight loss program delivered through a smartphone app and phone coaching for young people who are obese after a stem cell transplant. It aims to see if this convenient, at-home approach can help them lower their BMI and improve their health. The 4-month p…

This study is testing a new, 'smarter' approach to weight loss management. It compares a smartphone app that adjusts support based on your progress against a standard, more expensive group program and a self-guided approach. The main goal is to see if the adaptive app can help pe…

This VA study is testing a new, combined treatment program for Veterans who have both PTSD and obesity. The program merges proven mental health therapy with weight management support, including medication reviews. Researchers want to see if this integrated approach helps Veterans…

This study is testing if placing a temporary balloon in the stomach, combined with diet and exercise, helps obese adults with uncontrolled asthma breathe better. Researchers will compare this approach to diet and exercise alone. The main goal is to see if more people using the ba…

This study is testing whether a gentle, non-invasive electrical stimulation to a specific part of the brain can help people eat less and lose weight. Overweight adults will receive either real or fake stimulation while following a reduced-calorie diet for several weeks. Researche…

This study is testing whether a culturally informed sleep extension program can help African American adults with obesity get more sleep and increase physical activity. Researchers will first gather community input to design the program, then test it with 90 participants who curr…

This study is testing whether two popular weight-loss phone apps can help low-income Hispanic adults with type 2 diabetes lose weight and improve their blood sugar control. For 6 months, 45 participants will track their daily weight and blood sugar, using either one of the apps o…

This is an early-stage study to check the safety and how the body processes a new drug called LY4086940. It will involve about 201 healthy people and people who are overweight, have obesity, or have type 2 diabetes. The main goal is to see if the drug is safe and well-tolerated a…

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This study is testing whether a medication called empagliflozin can improve artery health in veterans with obesity. Fifty veterans aged 30-60 will take either the medication or a placebo pill daily for 12 weeks. Researchers will measure changes in artery stiffness to see if the d…

This study is testing whether a diet focused on plant-based proteins can help adults aged 55 and older with obesity lose weight. Over six months, participants receive dietary counseling and are randomly assigned to follow either a mostly plant-based or a mostly animal-based high-…

This study is testing a new program designed to help overweight or obese patients on the kidney transplant waitlist lose weight. The program combines education, technology tools, and support from a nurse, pharmacist, and dietitian. The goal is to see if this approach is practical…

This study compares two surgical approaches for people whose initial sleeve gastrectomy weight loss surgery didn't work well enough. Researchers are testing whether a newer, simpler procedure (SADI-S) works as well as the standard revision surgery (DS) but with fewer complication…

This study is testing if a newer, simpler version of gastric bypass surgery works as well as the current standard surgery for severe obesity. It will enroll 368 people to see if the newer procedure leads to similar weight loss and has the same risk of nutritional problems over tw…

This study is testing whether drinking whole milk or nonfat milk for one year affects children's weight, body fat, and risk factors for heart disease and diabetes. Researchers will enroll 200 children aged 9-12 who are above average weight and randomly assign them to drink three …

This study is testing a new version of a common weight loss surgery (sleeve gastrectomy) to see if it can better control severe acid reflux disease (GERD). Researchers will compare the new surgical technique to the standard one in 44 patients who already have GERD. They will meas…

This large, Phase 3 study aims to test the safety and effectiveness of different weight management medications for children and teenagers with obesity or overweight. It will enroll 125 young participants aged 12 to under 18 who have previously tried lifestyle programs without eno…

This is a very early-stage study to check the safety and how the body processes a new injectable drug called HRS-5817. It will involve 92 healthy adult volunteers, some with obesity and some without. The main goal is to see how safe the drug is and how it behaves in the body when…

This study is testing whether a daily drink containing ketone esters can help improve liver health and blood sugar control in adolescents with obesity and fatty liver disease (MASLD). For 6 weeks, 40 participants will be randomly assigned to drink either the ketone supplement or …

This study compares two training programs designed to help community health centers provide better weight management care to Medicaid patients. It will train doctors, dietitians, and other health workers at clinics across the country. The research will measure which training appr…

This study is testing whether combining weight-loss surgery with newer GLP-1 weight-loss medications (like semaglutide) works better than surgery alone for people with severe obesity. It aims to help patients lose more weight and keep it off long-term, while also improving relate…

This study looks at whether free exercise classes in community parks help older adults improve their health. Researchers will analyze data from 1,000 Miami-Dade County residents aged 50+ who participate in regular park-based fitness sessions. The program includes aerobic exercise…

This is the first human study to test the safety and basic effects of a new drug called LY4167586 for weight management. It will involve 84 otherwise healthy adults with obesity or overweight. Researchers will give single doses to see how the body handles the drug and monitor for…

This study is testing whether a new obesity medication called survodutide helps the body burn fat and use energy more efficiently than an existing drug called semaglutide. Researchers will enroll 60 adults with obesity and randomly assign them to receive either survodutide or sem…

This study is testing different ways to increase the dose of an experimental weight management medication called NNC0519-0130. Researchers want to see if certain dosing methods can reduce side effects that might occur when people take the medication. The 24-week study involves 11…

This is the first human study to test the safety of a new experimental drug called HRS-5817 in people with obesity. Researchers will give single injections to 40 participants to see how their bodies handle the drug and check for side effects. The main goal is to determine if the …

This study is testing a 6-month support program designed to prevent heart failure in adults with type 2 diabetes and obesity who have limited income and resources. The program combines exercise training at a local YMCA with problem-solving coaching and regular check-ins from a co…

This study is testing a new weekly injection called KAI-9531 to see if it helps people with obesity or overweight lose weight and improve related health issues like high blood pressure or cholesterol. About 1,800 adults who have struggled to lose weight through diet and exercise …

This study aims to see if two different versions of the drug survodutide work the same way in the body. It will involve 80 adults who are living with overweight or obesity. Participants will receive both drug versions in a random order to compare how much of the drug gets into th…

This study is testing a new weekly injection called NNC0662-0419 to see if it is safe and helps people lose weight. It will involve about 220 adults living with overweight or obesity. Some participants will receive the new medicine, while others will get a placebo (an inactive sh…

This study is testing whether an 8-week program combining mindful eating and yoga is practical and helpful for adults with overweight or obesity. Researchers want to see if the program improves mindfulness, eating habits, physical activity, and health markers like blood sugar. Th…

This study is testing a new medical device that uses magnets to create a connection in the digestive system. The goal is to help adults with obesity lose weight and improve type 2 diabetes by partially rerouting food. Researchers will check if the magnets can be placed correctly,…

This study is testing whether a new investigational drug called BGM0504 works as well as or better than an existing weight loss medication (tirzepatide) for adults with obesity. About 90 participants will receive one of the two drugs for 26 weeks, and researchers will measure cha…

This study is testing a new weekly injection called eloralintide to see if it helps adults with obesity or overweight lose weight and improve their health. It will involve nearly 2,000 people who do not have type 2 diabetes. Participants will receive either the real injection or …

This study is testing a new weekly injection called NNC0487-0111 to see if it helps people with obesity lose weight and is safe to use. About 1,150 participants will be randomly assigned to receive either the real injection or a placebo (a dummy injection with no medicine) once a…

This study aims to see if a specific eating schedule helps people keep weight off after losing it. It will compare people who eat all their food within an 8-hour window to those who eat within a 12-hour or longer window. All participants will first follow a weight-loss diet, and …

This study is creating and testing a new program to help people who are planning weight-loss surgery. The goal is to help them quit smoking and lose weight at the same time before their operation. The program combines two medications with behavior change therapy. Researchers will…

This study is testing whether a smartphone app, combined with remote coaching, can help overweight or obese African American women become more physically active. The goal is to see if increasing daily steps can improve heart health and help control weight. Researchers will compar…

This study is testing whether taking the supplement N-acetylcysteine (NAC) can make high-intensity interval training more effective for improving health in adults with overweight or obesity. Sixty participants will do a 12-week exercise program, with half also taking NAC pills an…

This early-stage study aims to check the safety and how the body processes a new drug called LY3549492 in healthy adults who are overweight or have obesity. About 120 participants will receive multiple doses over approximately 8 weeks while researchers monitor for side effects an…

This study is testing how a new combination drug called CagriSema affects the body's energy use compared to a weight-loss diet. Eighty adults with obesity will be randomly assigned to receive either the drug or follow a reduced-calorie diet for part of the study, then all will re…

This study is testing a new, less invasive endoscopic procedure called Pylorus Sparing Antral Myotomy (PSAM) for weight loss. It involves making a small cut in the stomach muscle to slow down how quickly food leaves the stomach, which may help people feel full longer and lose wei…

This study is testing a 24-week lifestyle program called Inspire HER, designed specifically for Black women at risk for heart disease. The program provides health education, physical activity guidance, and social support resources. Researchers will compare the program's effective…

This large, late-stage study is testing a weekly injection called eloralintide for adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The goal is to see if the drug can help reduce the number of breathing pauses during sleep (sleep apn…

This study is testing a 24-week community program called Black Impact, designed to improve heart health and reduce stress in Black men. Participants will receive weekly physical activity, health education, and support from coaches. The goal is to see if this program can be a scal…

This study is testing a practical counseling program to help reduce obesity in children. It involves about 6,600 children, aged 2 to 8, who are overweight. Doctors will talk with parents about healthy habits and refer families to trained coaches who will provide support and guida…

This large, late-stage study is testing a once-daily pill called orforglipron to see if it helps people lose weight and is safe. It will enroll about 1,200 adults who have obesity or are overweight, some of whom also have type 2 diabetes. The main goal is to see how well the pill…

This study tests a community health worker program designed to improve heart health in young, low-income migrant farmworker women. The program provides peer support and helps connect women to local resources, aiming to reduce stress, social isolation, and risk factors like high b…

This large study aims to find out if a weight loss medication (Contrave/Mysimba) increases the risk of serious heart problems like heart attacks or strokes. It will enroll 8,600 overweight or obese adults who already have a higher risk for heart disease. Participants will be rand…

This early-stage study is testing whether a new experimental drug called NNC6989-0001 is safe for people with overweight or obesity. The trial will enroll 96 healthy adults to receive either the drug or a placebo, with researchers carefully monitoring for side effects. This is th…

This early-stage study is testing a new drug called ARO-ALK7 to see if it is safe and how it affects the body in adults with obesity. Some participants will also take a common diabetes/weight loss medication (tirzepatide) to see if the new drug works alongside it. The main goal i…

This study is testing whether a new injectable drug called taldefgrobep alfa can help adults with overweight or obesity lose weight. Researchers will compare the drug to a placebo (inactive shot) in 150 participants over 24 weeks to see how much body weight changes and check for …

This large, late-stage study is testing whether a new injectable drug, maridebart cafraglutide, can help people who have a specific type of heart failure and are also obese. The main goal is to see if the drug, added to standard care, can reduce the risk of dying from heart probl…

This study is testing a medication called efsubaglutide alfa to see if it can help people who are still obese six months after having metabolic (weight loss) surgery. It will involve 60 participants who will receive either the real drug or a placebo (dummy treatment) to compare r…

This study is testing a new type of clinic designed to help people who have both obesity and heart disease. It will follow 60 adults for one year to see if the clinic helps them lose weight, improve their diet and fitness, and reduce stress. The goal is to see if this combined ap…

This study is testing whether taking glutamine, a common amino acid, as a powder for 8 weeks can help improve blood sugar control and ease irritable bowel syndrome (IBS) symptoms in people with obesity. It will involve 110 participants who will be randomly assigned to receive eit…

This study is testing whether a 12-month, phone-based weight management program can help young adult cancer survivors (ages 18-39) who have overweight or obesity. Participants are randomly assigned to either a guided program with personalized goals, digital tools, and peer suppor…

This study is testing different ways to increase the dose of an investigational weight loss medication called retatrutide. It aims to see which dosing plan is most effective and safe for helping people with obesity or overweight lose weight and improve related health measures. Th…

This study is testing if adding one of two behavior strategies to a standard weight loss program helps people lose more weight. The 'AVOID' strategy helps people change their home food environment, while the 'RESIST' strategy uses a game-like app to train impulse control. About 5…

This study is testing if a psychological therapy can help people stay physically active to prevent weight regain after bariatric surgery for obesity. Researchers will compare the therapy to an educational program in 164 adults who had surgery 8-20 months ago. Participants will at…

This study is testing a new magnetic device system (MagDI) designed to create a new connection in the small intestine. The goal is to see if this rerouting procedure is safe and can help with weight management and improve blood sugar control in adults with obesity, with or withou…

This study aims to reduce heart disease risk for Black women during and after pregnancy. Researchers will compare two support programs for 432 Black mothers with high blood pressure or obesity. One program provides basic health coaching, while the other adds community doula care,…

This program aims to reduce health inequities by connecting people in Massachusetts with support for three key health areas: cancer screening, weight management, and mental health. It will work with local clinics to offer evidence-based help to adults who are overdue for screenin…

This study is testing a new, very thin endoscope that goes through the nose instead of the mouth and doesn't require sedation. It aims to see if this method is a good, cheaper, and faster way to check for stomach and esophagus problems in people enrolled in a weight management pr…

This study is testing a new, quick ultrasound method to check for liver scarring (fibrosis) in overweight patients with fatty liver disease (NAFLD/NASH). Researchers want to see if this method, done during a routine stomach scope, is more accurate than other non-invasive tests fo…

This study aims to find the best family-centered program to help Hispanic parents and children lose weight and prevent obesity. Researchers are testing a mobile health intervention that uses text messages and video calls to promote healthy eating and activity habits. The program …

This study is testing a digital program delivered via web and mobile phone to help Hispanic women who have survived certain cancers and their adult daughters improve their physical activity and diet. The goal is to see if the program is practical and acceptable to use, and to che…

This study is testing whether giving an intravenous (IV) iron supplement before weight-loss surgery can prevent anemia and improve recovery afterward. Researchers will compare the IV iron treatment to a placebo in 200 obese patients who have low iron levels. The goal is to see if…

This study is testing a community program designed to help pregnant individuals eat healthier. The program provides education, skill-building, and a $15 grocery gift card to address food access. Researchers will enroll 40 pregnant adults to see if the program is practical and hel…

This study aims to find out if taking extra iron pills after sleeve gastrectomy weight loss surgery helps prevent iron deficiency anemia. Researchers will follow 66 patients for 6 months, comparing those who take a daily iron supplement plus a multivitamin against those who take …

This study is testing if an online program that helps child care providers manage their own weight and health can lead to better eating and more physical activity for the 2-5-year-old children in their care. Researchers will work with 84 child care centers, comparing a standard h…

This study is testing a digital program called 'Healthy Together' (Juntos) that uses a website and smartphone app. It aims to help Hispanic teens and their parents improve diet, increase physical activity, and prevent unhealthy weight gain. The program focuses on family support a…

This study is testing whether a weight loss program can help prevent or delay Alzheimer's disease in adults with Down syndrome. 81 adults with Down syndrome who are overweight but do not have dementia will be assigned to either a weight loss group or a general health education gr…

This study is testing a 2-year mobile health program designed to help young, active-duty Air Force personnel prevent weight gain. It will enroll 350 participants who will use a smartphone app and a Fitbit activity tracker to receive guidance on diet and exercise. The goal is to p…

This study is testing whether using special imaging technology to personalize ventilator settings during weight loss surgery can prevent lung complications afterward. Researchers will compare personalized settings against standard settings in 118 patients undergoing laparoscopic …

This study is testing whether following a Mediterranean diet during pregnancy can help prevent children from developing allergies by age two. Researchers will enroll about 276 healthy pregnant women and randomly assign them to follow either the Mediterranean diet or their usual d…

This study is testing a 6-month virtual diet education program called PEDALL. It aims to prevent unhealthy weight gain in children and teens (ages 5-21) who are receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL). Participants will be randomly assigned to re…

This study is looking at whether adding regular walking to a standard treatment plan helps reduce dry eye symptoms in obese women with Polycystic Ovary Syndrome (PCOS). All 40 participants will take medication and follow a low-calorie diet for 12 weeks, but half will also do trea…

This study is testing whether the common diabetes drug metformin can help adults with intellectual disabilities lose weight they've gained from taking necessary antipsychotic medications. It's the first randomized trial specifically for this underserved group, who face high rates…

This study is testing whether a daily breathing exercise program can help lower blood pressure and reduce shortness of breath during activity in adults with obesity. Researchers will compare a high-resistance breathing training device against a low-resistance sham device over eig…

This study is testing whether personalized nutrition and exercise advice can help prostate cancer survivors who are receiving hormone therapy. The goal is to reduce frailty, improve strength, and enhance quality of life. Participants will receive a 6-month program including diet …

This study aims to see if using a robotic system to perform sleeve gastrectomy (a common weight loss surgery) causes less pain right after surgery compared to the standard laparoscopic (keyhole) method. It will involve 91 patients at the Cleveland Clinic who are eligible for this…

This study is testing whether a specific type of nerve block, designed to spare a breathing muscle, can lower the risk of early breathing problems after shoulder surgery in adults with obesity. Researchers will compare this new approach to the standard nerve block to see if it re…

This study is testing whether adding laser acupuncture to standard diet and exercise advice helps overweight menopausal women lose weight and improve their body shape. Researchers will compare 40 women who receive the laser treatment to those who only get lifestyle guidance. The …

This study is testing a specific nerve-blocking injection to see if it can better manage pain after a common weight loss surgery. The goal is to reduce how much strong opioid pain medication patients need in the first day after their operation, which could help them recover faste…

This Mayo Clinic study is testing if tirzepatide (a medication approved for weight loss) can reduce the frequency and severity of bothersome hot flashes in postmenopausal women with obesity. It will also check if the drug affects measures of biological aging and heart health. The…

This study is testing whether a special breathing muscle training program can help obese breast cancer survivors exercise for longer periods and feel less tired. Researchers will compare a real breathing training program to a fake one, followed by exercise for all participants. T…

This study is testing whether patients having obesity surgery can get effective pain relief without opioids. Researchers are comparing standard opioid-based pain treatment against opioid-free approaches that use different medications and techniques. The goal is to see if avoiding…

This study is testing whether an 8-week Pilates exercise program can improve breathing and overall health in overweight and obese women. Participants will do core and abdominal exercises three times a week. Researchers will measure lung function, core strength, and quality of lif…

This study is testing a new home-based walking program that uses a special treadmill and virtual reality games. It aims to help children with conditions like cerebral palsy, neuromuscular diseases, or obesity improve their walking ability, strength, and overall quality of life. T…

This study is testing whether a weekly injection called retatrutide can safely reduce chronic low back pain in adults who also have obesity or are overweight. Researchers will compare the injection to a placebo (a dummy treatment) in about 586 participants over 80 weeks. The main…

This study is testing a year-long program designed to help people with severe obesity cope with the stress and discrimination they may face because of their weight. About 210 participants will either join the program, which includes physical activity and social well-being worksho…

This study is testing whether group counseling can help people who feel shame or stigma because of their health condition. Researchers are enrolling 195 adults with conditions like obesity, cancer, HIV, diabetes, or chronic pain who report feeling stigmatized. Participants will t…

This study is testing if applying a special elastic tape (kinesio tape) to the chest can help people who are overweight or obese. Researchers want to see if the tape improves lung function, breathing muscle strength, and sleep quality over four weeks. The goal is to find a simple…

This study is testing if a special vacuum dressing helps abdominal wounds heal better after breast reconstruction surgery in patients with obesity. It compares the vacuum dressing to standard bandages. The goal is to see if the vacuum dressing reduces wound complications and impr…

This study aims to understand how drinking a single glass of red or white wine might affect tiny particles in the blood called extracellular vesicles, which carry signals between cells. Researchers will enroll 8 healthy adults to drink wine and have their blood tested before and …

This research aims to understand how obesity leads to insulin resistance and related diseases like type 2 diabetes. It will study tiny particles released by fat tissue in 150 people with and without obesity who are already scheduled for surgery. The goal is to see if these partic…

This study aims to understand if certain hormones in a mother's body and breast milk are connected to her baby's growth, body fat, and eating preferences. Researchers will compare mothers with normal weight to those with overweight or obesity before pregnancy. Participants will p…

This study observes adults with risk factors like high blood pressure or diabetes during their regular cardiology visits. Researchers will collect health data to see how structured management affects measures like blood pressure and cholesterol. The goal is to better understand h…

This study aims to understand why people who work night shifts have a higher risk of becoming obese. Researchers will compare 1000 night shift workers and day workers across Europe, collecting health data, diet logs, and body measurements. The goal is to identify the biological a…

This is a long-term observational study aiming to understand why young people with type 2 diabetes are at higher risk for heart and blood vessel disease. It will follow 930 participants aged 12-25 for up to 25 years, comparing those with diabetes, those who are overweight, and he…

This study is testing whether the order people follow two popular diets affects how much body fat they lose. Overweight adults will try both a low-fat diet and a low-carb diet for 4 weeks each, with the order randomly assigned. Researchers will deliver all meals to participants' …

This study is testing whether two different ways of giving the drug survodutide—using a pre-filled syringe versus a pre-filled pen—work the same way in the body. It involves 56 healthy adults or adults with overweight or obesity. Researchers will take regular blood samples to mea…

This study aims to understand how a mother's health, weight, and blood sugar during pregnancy affect her child's growth and risk for obesity, diabetes, and fatty liver disease later in life. Researchers will follow 1,500 Hispanic and American Indian/Alaska Native mothers and thei…

This study is creating a collection of health information and DNA samples from 500 adults to help researchers better understand heart disease, high blood pressure, diabetes, and obesity. Participants provide their health data and biological samples, which will be stored for futur…

This early-phase study aims to understand why insulin, a hormone that normally helps control fat breakdown, doesn't work properly in people with upper body obesity. Researchers will study 64 adults, both with and without obesity, to see how specific fat cell proteins are involved…

This study aims to understand how a specific brain circuit influences feelings of fullness and food cravings. Researchers will use a safe, non-invasive magnetic stimulation technique on the brains of 150 healthy adults while they view food images. The goal is to learn how brain a…

This study aims to understand why weight-loss surgery is so effective by examining the relationship between two key body chemicals: cortisol (a stress hormone) and bile acids (digestive chemicals). Researchers will measure these chemicals in 30 obese women before and after they u…

This study aims to find the best way to conduct a standard meal test used in nutrition research. Healthy volunteers will eat two different test meals—one a fixed size for everyone and one adjusted to their body's needs—while researchers measure their blood sugar response. The goa…

This study aims to discover which personal traits—like genetics, metabolism, or health markers—best predict who will succeed at losing weight and maintaining that loss long-term. It will enroll 3,200 adults, both with and without obesity, to collect detailed health data. The goal…

This small, early-stage study aims to understand the role of high insulin levels in people with obesity. Researchers will give participants a drug called diazoxide for four days to temporarily lower their insulin production. They will measure daily blood sugar and insulin levels …

This study aims to understand how diet and nutrition affect the growth and development of young children in remote farming communities in Pakistan. Researchers will follow over 800 children from birth to age 5, tracking their diets, health, and development. The goal is to gather …

This study aims to find out why some people lose more weight than others after a specific, less invasive stomach-reduction procedure. Researchers will follow 205 adults with moderate obesity who had the surgery between 2017 and 2023. They will analyze blood, stool, and saliva sam…

This study aims to better understand MEHMO syndrome, a rare genetic disorder causing intellectual disability, seizures, and other serious health problems. Researchers will observe 150 participants, including affected individuals and their family members, to track symptoms over ti…

This study aims to understand how a 12-week high-intensity exercise program changes brain activity related to appetite and weight control. It will involve 15 adults with obesity, including some who have regained weight after bariatric surgery. Researchers will use brain scans, bl…

This study is a long-term safety check for people who previously received an experimental obesity drug called INV-347 in an earlier trial. Participants will not receive any new treatment; researchers will monitor their health and measure how long the drug stays in their system. T…

This early-stage study aims to understand how a new weight-loss drug candidate, BI 456906, affects specific targets in the liver and pancreas compared to an approved drug, semaglutide. It will enroll 30 adults with obesity and use special medical scans to see how much of these dr…

This study aims to understand how long people should fast and what happens when they temporarily stop taking the medication tirzepatide, in terms of how quickly their stomachs empty after eating. Researchers will use ultrasound scans to measure food and liquid remaining in the st…

This is the first study in humans to test the safety of a new experimental injection called HM17321, which is being developed for obesity. About 40 healthy adults will receive a single injection to see how their bodies react and process the drug. The main goal is to check for sid…

This study aims to understand if consuming oleic acid-rich sunflower oil changes how cholesterol is processed in abdominal fat tissue. Researchers will compare two types of sunflower oil in 40 women with obesity who are scheduled for weight-loss surgery. The goal is to gather kno…

This study aims to understand how body fat and gut bacteria might influence brain function, memory, and thinking in people with and without obesity. Researchers will collect tissue, blood, and gut bacteria samples from 60 participants who are already scheduled for fat removal sur…

This study aims to understand how aging changes the way our bodies respond to exercise, especially for older adults with prediabetes or related heart and metabolic risks. It will enroll 26 people who previously completed an exercise study to participate in a new 6-month aerobic e…

This study aims to understand how a low-carbohydrate diet and a dietary supplement called nicotinamide riboside (NR) affect the body's metabolism. Researchers will measure how these interventions change the way healthy, overweight adults and people with a specific genetic form of…

This study aims to understand how problems with executive function—the brain's management skills for planning and focus—affect physical performance and overall well-being in adults with obesity. Researchers will compare 100 adults with obesity, grouping them based on their cognit…

This study aims to learn more about rare and poorly understood diseases that affect the heart and blood vessels. Researchers will enroll up to 5,000 people, including patients, their relatives, and healthy volunteers, to collect medical data, images, and samples. The goal is to i…

This study aims to understand the heart health needs of adults in Washington D.C. area churches to design a future community weight loss program. Researchers will partner with church leaders to measure participants' weight, blood pressure, cholesterol, and activity levels. The in…

This study aims to understand how tiny particles in the blood, called extracellular vesicles, affect blood vessel function in people with type 2 diabetes. Researchers will study 60 adults with and without diabetes to see if these particles harm blood vessels and if regular exerci…

This study aims to understand why people from lower-income backgrounds often lose less weight in standard behavioral weight loss programs compared to those with higher incomes. Researchers will enroll 230 adults with obesity and track their weight, diet, and activity over six mon…

This study is testing whether a daily omega-3 supplement called SPM Active® can increase certain beneficial compounds in the blood and improve feelings of burnout, life satisfaction, and sleep quality in adults with obesity. Researchers will enroll 33 adults aged 45-60 to take th…

This early-stage study aims to check the safety and how the body processes an experimental oral medication called RO7795081 in healthy overweight or obese adults. Researchers will give the drug to 40 participants and measure its levels in the blood, while also checking if it affe…

This study aims to understand the many factors that influence body weight by observing and measuring physical and behavioral traits in adults. Researchers are recruiting 2,000 healthy adults of all body sizes—lean, overweight, and obese—to participate. The study involves detailed…

This study aims to understand how communication between gut bacteria and the brain might contribute to a loss of control over eating in people with obesity. Researchers will compare 108 adults with and without obesity, collecting data on their gut bacteria, blood markers, brain s…

This study is checking in on 301 mothers and their now 14-year-old children. The mothers were part of a trial 14 years ago that tested a special diet and exercise program during pregnancy. Researchers want to see if that program helped prevent the children from developing obesity…

This study aims to understand how the brain uses a fuel called lactate, especially in people with obesity. Researchers will compare brain blood flow and lactate levels during exercise in 24 adults with and without obesity. They also want to see if a short exercise program changes…

This study aims to understand how obesity relates to heart disease risk in Black men and women, as past research shows the connection may be different than in other groups. Researchers will enroll 2000 healthy, non-diabetic Black adults to measure body fat, blood fats, and how th…

This study aims to understand the connections between a woman's weight, her personal hygiene and bathroom habits, and symptoms like frequent urination or incontinence. Researchers will compare two groups of women (aged 18-45) based on their weight to see if these factors are link…

This study aims to understand how a mother and baby's emotional connection and feeding behaviors in the first year relate to the child's future risk of obesity. Researchers will observe 300 mother-infant pairs over several years, measuring growth, feeding interactions, and emotio…

This study aims to understand exactly how exercise training improves the function of tiny blood vessels in the muscles of people with obesity and metabolic syndrome. Researchers will study 25 sedentary adults, using specialized techniques to measure chemical signals and blood flo…

This study aims to understand how obesity affects iron absorption and loss in young women. Researchers will track 70 South African women with and without obesity over two years, measuring how their bodies process iron from their normal diets. The goal is to learn whether women wi…

This study is looking at whether drinking apple cider vinegar right before a meal can quickly reduce a specific marker of cell stress in adults with obesity. Researchers will compare two groups: one that drinks vinegar before a meal and one that drinks water. The goal is to gathe…

This study aims to understand why ultra-processed foods high in fat, sugar, or both are so hard to resist and may lead to overeating. Researchers will measure cravings, mood, and body chemistry in 50 adults with obesity after they eat different snack types. The goal is to identif…

This study aims to understand how the brains and metabolisms of people with obesity react differently to sugars, fats, and proteins compared to people of a healthy weight. Researchers will give 60 participants different liquid meals and use brain scans and blood tests to measure …

This study aims to understand if girls with higher body weight start puberty earlier than girls with normal weight. Researchers will use breast ultrasounds, blood tests, and other exams on 150 healthy girls aged 8-14 to get a clearer picture. The goal is to gather better informat…

This study aims to understand how the number of calories you eat changes the energy your body uses to digest and process food. Healthy volunteers will live in a clinic for about 35 days, eating controlled diets while researchers measure their metabolism in special rooms. The goal…

This study aims to create a detailed map of the different types of cells in body fat from older adults with obesity. Researchers will compare how a lifestyle program and an experimental drug that targets 'senescent' or worn-out cells affect insulin sensitivity and metabolism. The…

This study aims to understand how nerve activity affects blood sugar and blood pressure in people with obesity. Researchers will give 12 participants different pills (a placebo, a blood pressure drug, or a nerve-blocking drug) for two-week periods to see which one best improves t…

This study aims to understand how certain natural fats produced by the body might be connected to breast cancer and obesity. Researchers will compare 60 postmenopausal women, some with breast cancer and some without, and look at their weight, diet, activity levels, and blood mark…

This study aims to understand why fat tissue in the abdomen responds differently to the body's natural fat-burning signals in people with obesity compared to those without. Researchers will measure how fat cells release fatty acids in 24 adults with different body types. The goal…

This study aims to understand if people with obesity who also have binge eating or food addiction perceive sweet and salty tastes differently than those without these eating disorders. Researchers will measure taste sensitivity in 300 participants with obesity, grouping them base…

This study aims to understand how fasting and temporarily stopping popular GLP-1 weight-loss medications affect how quickly food leaves the stomach. It will involve 75 people with obesity who are already taking specific doses of liraglutide or semaglutide. Researchers will use ul…

This study is exploring whether drinking a bean smoothie for two weeks can improve gut and metabolic health. Researchers will compare adults who add the smoothie to their usual diet with those who don't. The goal is to gather information on how beans might influence the body to h…

This study aims to understand what matters more for improving heart and metabolic health: losing weight or eating a high-quality diet. Researchers will provide 70 adults with pre-obesity or obesity risk factors with different meal plans for 8 weeks, including healthy diets with a…

This study aims to understand the genetic causes of severe obesity that starts very early in childhood. Researchers will enroll 500 children and adults who were severely obese before age 6, ask health questions, perform a brief exam, and collect saliva or blood for genetic testin…

This study aims to understand if a popular weight-loss medication (semaglutide) affects bone strength in teens and young adults with obesity. Researchers will follow 120 participants for two years, comparing those taking the medication to those managing weight through lifestyle c…

This study aims to find out which of two common breathing machine settings works better for patients during weight loss surgery. Researchers will compare how well each method maintains oxygen levels and manages pressure in the lungs of 40 adult patients with obesity. The goal is …

This is a small, early-stage study to test a new procedure for measuring how the hormone insulin works in the body. Researchers want to understand how much insulin is actually needed to keep blood sugar normal. They will test this new method, called a Graded Insulin Suppression T…

This study aims to understand how obesity and aging affect the body's metabolism, which could lead to better health in later life. Researchers will observe 650 young and older adults, some with and some without obesity, to find biological signs of aging in the blood. The goal is …

This study aims to develop better MRI scanning methods to see the heart and arteries in more detail without using radiation. Researchers will compare these new MRI techniques to standard heart tests in up to 4000 adults, including both healthy volunteers and people with or at ris…

This early-stage study aims to understand if an experimental drug called angiotensin-(1-7) can improve heart and blood vessel health in people who have both obesity and high blood pressure. Researchers will give the drug or a placebo (saltwater) to 52 participants through an IV a…

This study aims to understand if a diet that promotes inflammation is linked to worse gum disease in people with obesity. Researchers will enroll 200 obese adults and compare their diets, gum health, and blood markers. The goal is to gather knowledge about the connection between …

This study aims to understand how eating a lot of fructose (a common sugar) changes the bacteria in your gut and affects your metabolic health, including liver fat and diabetes risk. Researchers will have 30 adults who poorly absorb fructose follow two different 12-day diets—one …

This long-term study aims to understand why some children develop unhealthy eating patterns and weight gain by following 1,500 kids aged 8-17 for up to six years. Researchers will track factors like sleep, mood, genetics, and brain activity to see how they influence eating behavi…

This study is testing whether a weight loss medication called liraglutide (Saxenda) affects brain health markers in people with multiple sclerosis, long COVID, or leukemia in remission who also have obesity and cognitive problems. Researchers will measure changes in a protein cal…

This online study aims to see if adding Nutri-Score labels (like a traffic light A-E rating) to items on a simulated food delivery app helps people select healthier meals. Researchers will recruit 870 adults who regularly use food delivery services to make hypothetical meal choic…

This is a long-term observational study that will follow 2800 pregnant women and their families in Weifang, China, for up to 18 years. The goal is to understand how factors like environment, nutrition, and lifestyle during pregnancy affect the short-term and long-term health of b…

This study aims to understand how growth hormone affects the cells that produce insulin in women who had high blood sugar during pregnancy (gestational diabetes). Researchers will compare 30 women with a past history of gestational diabetes to a control group without that history…

This study is observing whether a free, daily after-school program in community parks improves children's health. Researchers will analyze data from about 5,000 kids aged 6-14 who participate in the program, which includes sports, games, and nutrition lessons. The goal is to see …

This study aims to understand how a person's weight and blood sugar levels affect gene activity in their body tissues. Researchers will collect tissue samples from 20,000 people undergoing abdominal surgery to see how genes are expressed differently in those with obesity, diabete…

This study aims to understand how the body naturally tries to prevent weight loss. Researchers will observe 12 people with either low body weight or obesity during a short fast and refeeding period, measuring their energy intake and expenditure in a controlled room. The goal is t…

This is an early-stage study to check the safety and side effects of a new injectable drug called LY3971297. It will involve about 225 healthy adults and adults with obesity, high blood pressure, or reduced kidney function. The main goal is to see how the body handles the drug an…

This study is testing whether an educational program helps people who recently had a spinal cord injury understand their increased risks for heart disease, obesity, and diabetes. Researchers will enroll 250 adults within 4 months of finishing their initial rehab. The main goal is…

This study aims to understand the differences between brown fat, which burns energy, and white fat, which stores it. Researchers will collect small fat samples from 40 healthy adults and analyze them in a lab. The goal is to map how these fat types work, which could one day lead …

This study aims to understand how obesity harms blood vessels and whether exercise or weight loss surgery can reverse this damage by affecting how genes are turned on or off. Researchers will study 80 obese adults approved for weight loss surgery, comparing them to non-obese peop…

This study aims to find out if regular exercise during breastfeeding changes what's in the breastmilk of mothers who have overweight or obesity. Researchers will measure specific milk components and see if any changes might affect the baby's growth and health. The study involves …

This study aims to understand the connections between obesity, iron buildup in the brain, gut bacteria, blood sugar levels, and thinking skills like memory. Researchers will compare people with and without obesity, and follow some participants for a year after weight loss. They w…

This study aims to understand how body composition, specifically lean muscle mass, affects how the antiviral drug acyclovir is processed and eliminated by the kidneys in people with different body weights. Researchers will measure drug levels in the blood and urine of 20 healthy …

This study aims to understand if eating meals at unusual times, like late at night, affects your body's ability to manage weight and energy. Researchers will compare what happens when people eat soon after waking versus several hours later, while keeping sleep schedules the same.…

This early-stage study aims to understand how a new investigational drug for weight management, called HRS-7535, interacts with four common medications: acetaminophen (pain/fever), digoxin (heart), rosuvastatin (cholesterol), and omeprazole (heartburn). It will enroll 40 overweig…