OBESITY

This study tests whether matching weight-loss medications to a person's specific obesity type (like 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. About 100 adults aged 18-65 will take one of three FDA-approved drugs or join a weight-…

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and lifestyle coaching. Researchers want to see if it lowers blood pressure and helps w…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. Researchers will track side effects, weight loss, and blood sugar control to see if tirzepatide helps manage these condit…

This study looks at whether eating protein and/or fiber bars as part of a low-calorie diet helps overweight or obese adults lose weight and improve heart, joint, and metabolic health. About 144 participants will eat three bars daily for 12 weeks. Researchers will track weight, bo…

This study looks at whether semaglutide, a weight loss drug, can help people with HIV who are obese lose more weight than just diet and exercise. About 80 adults with well-controlled HIV will take semaglutide or follow lifestyle changes alone for 28 weeks. Researchers will also c…

This study tests if adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning improves gum health in people with both gum disease and obesity. Twenty-four adults with obesity and moderate to severe gum disease will receive either standard clean…

This study tests a once-weekly injection called eloralintide to help adults with obesity or overweight lose weight. About 1,980 participants who do not have type 2 diabetes will receive either the drug or a placebo for 75 weeks, with some continuing for up to 2 more years. The go…

This study compares tirzepatide, a once-weekly injection, to standard care for weight loss and preventing type 2 diabetes in 3000 adults with obesity but no diabetes. Participants must have a BMI of 30-34.9, a high waist-to-height ratio, and at least one weight-related health iss…

This study tracks 200 obese adults in the EU who choose to get the Orbera365 intragastric balloon for weight loss. Researchers will monitor serious side effects and how many people lose at least 10% of their total body weight over up to 12 months. The balloon is placed in the sto…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study tests a new drug, maridebart cafraglutide, in 250 adults with obstructive sleep apnea who are overweight or obese and already use a breathing machine (PAP therapy). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 …

This study tests different ways to increase the dose of the drug retatrutide to help people with obesity or overweight lose weight. About 600 participants without diabetes will receive the drug or a placebo for up to 113 weeks. The main goal is to see how much weight they lose an…

This study looks at whether combining bariatric surgery with GLP-1 weight-loss drugs works better than surgery alone for severe obesity. About 200 adults aged 18-60 with a BMI of 35 or higher will take part. The goal is to see if the combo leads to greater weight loss and better …

This study looks at whether adding protein supplements to a weight-loss plan (diet and the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part, with some getting just diet, some diet plus…

This study tests a new weekly injection, KAI-9531, to see if it helps people with obesity lose more weight than semaglutide (the drug in Ozempic/Wegovy) or a placebo. About 1,200 adults with a BMI of 35 or higher who have tried and failed to lose weight through diet and exercise …

This study looks at whether a stepped-care digital health program can help adults with obesity maintain at least 5% weight loss for a year. Participants first lose weight through a 16-week diet and group counseling. Those who succeed are then randomly assigned to usual care, self…

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by standard inhalers. About 84 participants will be randomly assigned to receive the balloon plus life…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults to see if the drug helps control disease risk. The goal is…

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The main goals are to check safety, how the drug moves through the body, and early signs of effectiveness. Up to 564 participants will take sing…

This study tests a modified version of sleeve gastrectomy (a common weight-loss surgery) to see if it can reduce acid reflux, a frequent side effect. About 44 adults with obesity and GERD will be randomly assigned to the standard or modified surgery. Researchers will measure chan…

This study tests a new medicine called KAI-9531, given as a weekly shot, to help people with obesity lose weight. About 250 adults with a BMI of 35 or higher who have tried and failed to lose weight through diet and exercise in the past 6 months will take part. Participants will …

This study tests whether empagliflozin, a drug used for diabetes, can improve artery stiffness in 50 veterans with obesity but without diabetes. Participants will take either the drug or a placebo for 12 weeks, and researchers will measure changes in arterial health using a non-i…

This study is testing a new, less invasive procedure called PSAM that aims to help people with obesity lose weight by slowing down how fast the stomach empties. The procedure uses an endoscope (a thin tube passed through the mouth) to make cuts in the stomach muscle, without remo…

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can improve the quality of embryos in women who are overweight or obese. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive sem…

This study is testing whether a daily capsule made from fermented fruits and vegetables (Rutazyme® lemon fermented product) can improve metabolic health in adults with obesity. Forty adults aged 18-65 with a BMI of 27 or higher will take either the active capsule or a placebo for…

This study tests a new drug called brenipatide in 150 healthy adults with overweight or obesity. Participants receive injections under the skin to see how different doses affect body weight and safety. The study lasts about 42 weeks and aims to find out if the drug can help contr…

This study tests whether a virtual weight management program, including a weight-loss drug called semaglutide, can help people with obesity and advanced kidney disease lose enough weight to become eligible for a kidney transplant. About 60 adults with a BMI over 35 and high risk …

This study aims to find the best telehealth weight loss approach for older adults (ages 65-85) who have obesity and at least two chronic conditions. Researchers will compare different treatment combinations to see which helps participants lose the most weight over 52 weeks. The g…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) helps adults with obesity lose mostly fat while keeping muscle and bone. 63 participants will receive either the combo, tirzepatide alone, or bimagrumab alone for 52 weeks. …

This study tests a practical program that uses motivational interviewing—a supportive counseling style—to help children ages 2 to 8 with overweight or obesity lower their body mass index (BMI). About 6,600 children from Kaiser Permanente clinics will take part over two years. The…

This early-stage study tests a new drug called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The main goal is to check safety and how the drug moves through the body. Researchers will also see if it helps with weight loss, either alone or with anot…

This study tests whether a low-dose weekly injection of semaglutide can help obese adults without diabetes lose weight and improve heart health. Sixty Pakistani adults aged 18 and older with a BMI of 27.5 or higher will receive the drug for 24 weeks, along with diet and exercise …

This study tests a new medicine called KAI-9531, given as a weekly shot, to help people with obesity or overweight who also have weight-related health problems (like high blood pressure or sleep apnea) but do not have diabetes. About 1,800 adults will receive either the drug or a…

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 24 doctors and 48 patients will take part. The goal is to see if the tool is easy to use and…

This study tests whether inviting friends, family, or coworkers to join a weight loss program helps Black or Hispanic adults with obesity lose more weight. About 264 participants will be randomly assigned to a lifestyle program either alone or with up to two social network member…

This study tests a new magnetic system (MagDI) that creates a shortcut in the small intestine to help with weight loss and type 2 diabetes. It involves 60 adults with obesity (BMI 30-50) who have diabetes or regained weight after previous weight-loss surgery. The goal is to see i…

This study tests a new weekly injection called retatrutide (LY3437943) to help people with obesity or overweight who also have weight-related health problems like high blood pressure or heart disease. About 300 adults will receive either the drug or a placebo, along with diet and…

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and improve blood sugar control. Thirty adults will use the app for 6 months, weighing themselves daily and checking blood sugar before and after meals. The goal is to see…

This study tests whether a new medicine called NNC0487-0111 is safe and effective for weight loss in adults with obesity. About 600 participants will receive either the active drug or a placebo as a weekly injection under the skin. The main goal is to see how much body weight the…

This study tests a community-based program called FEAST Perinatal Support Program for 40 pregnant adults, mostly Latino, who qualify for food assistance. The program provides nutrition education, skill-building, social support, and grocery gift cards to improve diet and health du…

This study is testing whether a probiotic supplement can help adults with obesity lose weight by changing gut bacteria. One hundred participants will take either the probiotic or a placebo for several weeks. The goal is to see if this safe, easy-to-take option can support weight …

This study tests a new once-weekly medicine called eloralintide to help adults who are overweight or obese and also have type 2 diabetes lose weight. About 1035 participants will receive either the drug or a placebo for 75 weeks. The main goal is to see how much weight they lose …

This early-stage study is testing whether attapulgite, a natural clay mineral, can help people with obesity or overweight with type 2 diabetes lose weight safely. Researchers will measure changes in body mass index (BMI), waist size, and body fat. The trial aims to enroll 40 adul…

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests whether adding weight-loss medications (topiramate, phentermine, or both) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and have regai…

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach helps Veterans lose more weight and reduce PTSD symptoms better than standard care. About 182 Veterans will take part…

This study looks at whether resistance exercise and/or extra protein can help people with obesity keep their muscle and improve physical function while taking semaglutide or tirzepatide for weight loss. About 232 adults will be randomly assigned to one of four groups: control, ex…

This study tests if weight-loss surgery is better than standard medical treatment for getting rid of nonalcoholic steatohepatitis (NASH) in obese people with advanced liver scarring. About 100 participants will be randomly assigned to either surgery or medical care. The main goal…

This study looks at how a new investigational medicine called CagriSema affects the body's energy use compared to a calorie-reduced diet. About 80 adults with obesity will be randomly assigned to either CagriSema or a weight-loss diet for the first part, then everyone gets CagriS…

This study tests whether a new drug, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a placebo, alon…

This early-stage study tests a new drug, MBX 4291, in 124 adults with obesity (BMI 30 to under 50) to see if it is safe and how the body handles it. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to track any side effects, not to meas…

This study looks at whether adding whole-body vibration sessions to a standard 3-week weight-loss program helps obese teenage boys burn more energy while resting. About 28 boys aged 13-18 will either get the vibration training plus the program or just the program alone. Researche…

This study tests whether the Mayo Clinic Diet helps people with obesity lose at least 5% of their body weight compared to standard care. Researchers will follow 250 adults for up to a year to see how well the diet works, what barriers people face, and whether weight loss lasts. T…

This study tests whether mobile health technology, like activity trackers and smartphone apps, can help overweight or obese African American women increase their physical activity. Participants will wear a wrist device, use a study app, and may receive coaching or home health dev…

This study looks at whether adding extra protein to the diet can help adults with obesity keep their muscle while losing weight with GLP-1 medications. About 130 people aged 30-65 with a BMI over 30 will take part. Half will get standard medication, and the other half will also g…

This study tests an experimental daily pill called KAI-7535 to see if it helps people with obesity or overweight lose more weight than a placebo. The trial includes 320 adults who also have at least one weight-related health problem like high blood pressure or sleep apnea. Partic…

This study tests two minimally invasive procedures—EndoZip and Apollo ESG—to help obese adults lose weight. Participants (ages 21-65, BMI 30-50) who haven't succeeded with diet or exercise will get one of the two treatments, plus lifestyle coaching. The main goal is to see which …

This study tests a once-weekly medicine called tirzepatide in 300 teens with obesity and at least two weight-related health issues like high blood pressure or prediabetes. Participants receive the drug or a placebo along with healthy eating and exercise advice for about 76 weeks.…

This study looks at whether a probiotic called Lactobacillus paracasei LC-19 can help overweight or obese adults lose weight and improve metabolism. About 140 people will take part, with some receiving the probiotic, some receiving the weight-loss drug semaglutide, and others a p…

This study looks at whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30 or higher) lose weight and improve their fertility. About 98 men aged 22-40 and their partners will take part. The goal is to see if weight loss leads to better …

This study tests a once-daily pill called orforglipron in 125 teens aged 12–17 who have obesity or are overweight with related health issues. Participants take either the drug or a placebo for about 18 months. The goal is to see if the pill helps lower body mass index (BMI) and i…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants receive either the drug or a placeb…

This study looks at whether doing aerobic exercise before eating (fasted) is better for heart health and weight loss than exercising after a meal. Over 16 weeks, 40 adults with obesity will follow an exercise program either fasted or fed. Researchers will measure changes in body …

This study tests whether metformin, a diabetes medication, can help reduce weight gain caused by antipsychotic drugs in adults with intellectual or developmental disabilities. About 100 participants will receive either metformin or a placebo for several months. The goal is to fin…

This study tests whether two approved drugs, mirabegron and tadalafil, can improve how the body handles sugar in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drugs can reverse prediabetes a…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain muscle mass and strength while taking popular weight-loss drugs like Ozempic or Mounjaro. About 100 adults who recently started or plan t…

This study tests whether a diet rich in plant-based protein can help adults aged 55 and older with obesity lose weight while preserving muscle. Two hundred participants will follow a calorie-restricted diet for six months, with either mostly plant or mostly animal protein. Resear…

This study tests whether a dietary supplement made from omega-3 and omega-6 fats (called SPMs) can reduce inflammation and improve blood vessel function in 60 adults with obesity and high blood pressure. Participants will take the supplement or a placebo for 12 weeks. The goal is…

This study looks at whether adding different exercise programs to a Mediterranean diet can lower inflammation better than diet alone in adults aged 18-65 with obesity and non-alcoholic fatty liver disease (NAFLD). About 90 participants will be assigned to diet only, diet plus one…

This study is testing whether a special clinic focused on heart health and weight management can help obese adults with heart disease lose weight and improve their health. Researchers will track weight, body mass index, and belly fat over 12 months. The study involves 60 particip…

This study tests a 6-month program that combines exercise training, problem-solving help, and community health worker support for 210 adults with type 2 diabetes, obesity, and early heart problems. Participants must have low income and live in Baltimore or Washington County, Mary…

This study tests whether a daily dose of nicotinamide (a form of vitamin B3) can stop or reverse liver scarring (fibrosis) in people with fatty liver disease. Thirty overweight or obese adults with liver scarring will take either nicotinamide or a placebo for one year. Researcher…

This study tests whether a mobile health program can help young adults (ages 18-39) who have survived cancer and are now overweight or obese lose weight. Participants will be randomly assigned to either a full mobile weight management program or a self-guided version with digital…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. Sixty adults aged 21-65 with a BMI of 25 or higher and signs of insulin resistance will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. Re…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who do not use a breathing machine (CPAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants will receive either the drug or a p…

This study looks at whether a weight loss procedure called Endoscopic Sleeve Gastroplasty (ESG) is safe and effective for people with ulcerative colitis (UC) who are obese and need or have had colon removal surgery. About 12 participants will be enrolled. The goal is to help them…

This study tests a new once-weekly injection called eloralintide for adults who are still obese or overweight despite taking a weekly incretin drug (like Ozempic or Wegovy). About 900 participants will receive either eloralintide or a placebo for 80 weeks to see if it helps them …

This study tests a drug called ACM-001.1 in 120 obese adults who are taking semaglutide (a weight-loss medication). The goal is to see if ACM-001.1 can reduce the muscle loss that often happens with weight loss. The study has two parts: one where participants take both drugs toge…

This study tests whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. Participants will weigh themselves daily and check blood glucose before and after meals for 6 months.…

This study tests a new drug called BGM0504 against an existing weight-loss medication, tirzepatide, in adults with obesity. The goal is to see which works better for weight loss and safety over 26 weeks. About 90 people will participate, and they must have a BMI between 35 and 45…

This study is testing several new experimental treatments to help adults with obesity or overweight manage their weight over the long term. About 1,200 participants will be assigned to different treatment groups to see which approach works best and is safest. The goal is to find …

This study compares two weight-loss surgeries for people with severe obesity: the standard Roux-en-Y gastric bypass and a newer omega gastric bypass with a shorter intestinal loop. About 368 adults aged 18-65 will be followed for 2 years to see if the omega bypass works as well f…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a program that includes counseling, text messages, phone support, and self-monitoring tools. About 1,785 drivers in New York City will take part. The goal is to find the most effective and…

This study explores whether changing gut bacteria with antibiotics can prevent weight regain after losing at least 10% of body weight. Researchers will give antibiotics or a placebo to 200 adults with obesity (BMI 28-35) and track weight and microbiome changes. The goal is to fin…

This study tests whether a time-efficient breathing muscle training can lower blood pressure in adults with obesity. About 44 participants with a BMI between 30 and 40 will do the training at home and have their blood pressure measured in the lab and at home. The goal is to see i…

This study tests a new weight loss program called SMARTer that starts with simple steps and adds more support only if needed. It compares this approach to a standard program and a self-guided option. About 492 adults with obesity will take part to see if SMARTer can help people l…

This study tests whether a daily ketone ester drink can reduce liver fat and improve blood sugar control in adolescents aged 18-25 with obesity and metabolic fatty liver disease (MASLD). Participants are randomly assigned to receive either the ketone drink or a placebo for 6 week…

This study tests whether giving an iron infusion before weight-loss surgery can prevent anemia and improve quality of life. About 200 obese adults with low iron will receive either the iron supplement or a placebo. The goal is to see if their hemoglobin levels stay healthier afte…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests a new medicine called MET097, given as a weekly shot under the skin, to help adults with overweight or obesity and type 2 diabetes lose weight. About 1,000 people will take part for 21 months, with some receiving the study drug and others a placebo. The goal is t…

This study tests if the drug efsubaglutide alfa can help people who are still obese 6 months after metabolic surgery lose more weight. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they los…

This study is testing a new device that uses magnets to create a shortcut in the digestive system, helping people with obesity and type 2 diabetes lose weight and control blood sugar. About 35 adults aged 18-65 with a BMI between 30 and 50 will receive the procedure. The goal is …

This study looks at the best way to maintain weight loss after initial success with a high-dose weight-loss drug (mazdutide). Researchers will compare a year of intensive lifestyle changes, a lower weekly dose of mazdutide, or both, in 420 adults with obesity. The goal is to find…

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older veterans who have both obesity and signs of muscle loss (sarcopenia). About 50 veterans aged 55 and older will take part. The goal …

This early-stage study tests a new drug called DA-1726 in 139 people with obesity who are otherwise healthy. The main goal is to check if the drug is safe and to see how the body handles it. Researchers will also look at how the drug affects body composition and weight.

This study tests a new drug, maridebart cafraglutide, in about 5,000 adults with heart failure and obesity. The goal is to see if it reduces heart failure events like hospitalizations and improves symptoms. Participants receive the drug or a placebo alongside standard care.

This study tests a new medicine called NNC0487-0111, given as a weekly shot, to see if it helps people with obesity lose weight safely. About 1,150 adults will receive either the active drug or a placebo (dummy shot) for several months. The main goal is to measure how much body w…

This study tests whether taking oral glutamine, an amino acid, for 8 weeks can improve insulin resistance and irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo protein powder. Researchers will …

This study looks at whether losing weight while following the Dietary Guidelines for Americans is better for heart health than just following the guidelines without losing weight. Researchers will compare a healthy diet with calorie restriction to a typical American diet in 70 ad…

This study tests whether the weight-loss medication tirzepatide can improve control of atrial fibrillation (an irregular heartbeat) in people with obesity. About 100 adults with a BMI of 27 or higher and symptomatic AFib will receive either tirzepatide or a placebo. The main goal…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural day-night blood pressure rhythm in people with obesity. Obese individuals often have high nighttime blood pressure, which increases heart risks. Researchers will co…

This study looks at whether time-restricted eating (eating all meals within 8 hours or less) can help people with obesity maintain weight loss after a calorie-restricted diet. About 212 participants will follow a diet to lose 8-10% of their weight, then be split into two groups: …

This study tests two new drugs, CagriSema and cagrilintide, to help children and adolescents with overweight or obesity lose weight. About 460 participants will be randomly assigned to receive one of the study drugs, an existing drug (semaglutide), or a placebo. The main study la…

This study looks at 151 people who had sleeve gastrectomy but didn't lose enough weight or regained it. It compares a newer, simpler surgery (SADI-S) with a standard, more complex one (BPD-DS) to see which works better with fewer side effects. The goal is to help patients achieve…

This study compares an intensive weight loss program—including meal replacements, behavioral support, and weight-loss medication—to standard care for 600 adults aged 18-60 with severe obesity and related health issues. The goal is to see if the intensive approach leads to better …

This pilot study is testing a smartphone app with telephone coaching to help teens and young adults (ages 13-30) who are overweight or obese after a stem cell transplant. The goal is to see if the app can help them lose weight and improve their health. The study will enroll 20 pa…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests whether an online weight management program for child care teachers can improve the diet and physical activity of 2-5-year-old children in their care. About 84 child care centers and over 900 participants (directors, teachers, and children) will take part. Some c…

This study tests an experimental medicine called CS060380, taken with a weight-loss drug (semaglutide), in adults with fatty liver disease (MASH) and obesity. About 120 people will join for up to 54 weeks. The goal is to see if the drug reduces liver fat and body weight safely.

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or obese and have type 2 diabetes. About 630 adults will receive either the active drug or a placebo to see if it safely helps reduce body weight and improve blood sugar control. The go…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This study tests a once-weekly injection called tirzepatide in adults who have obesity or are overweight with related health problems, but do not have type 2 diabetes. Participants receive either the drug or a placebo, along with diet and exercise advice. The main goal is to see …

This early-stage study tests a new drug called ARO-ALK7 in 138 adults with obesity, some of whom also have type 2 diabetes. The goal is to check if the drug is safe and how it affects weight and blood sugar. Participants receive either the drug or a placebo, and some may also tak…

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat healthier and control blood pressure. The goal is to see if…

This study tests a remote behavioral program for people who have regained at least 5% of their weight after bariatric surgery. 200 participants will either receive the program or standard advice. The goal is to see if the program helps reverse weight regain and improve eating hab…

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either the dru…

This study is testing a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults who smoke and are preparing for weight-loss surgery lose weight and quit smoking. About 20 participants will try the program to see if it is feasible and accepta…

This study tests whether a simple saliva test can predict how well people with obesity will respond to the weight-loss drug semaglutide. Researchers will compare weight loss in participants who have a specific biomarker in their saliva versus those who don't. The goal is to make …

This early-stage study tests a new injection called HRS-5817 in healthy adults, some with obesity and some without. The main goal is to check if the drug is safe and how the body processes it. About 92 volunteers aged 18-55 will receive single or multiple doses under close monito…

This study compares two ways to help people with overweight or obesity lose weight and eat healthier. One approach focuses on avoiding tempting situations (AVOID), while the other trains the brain to resist impulses (RESIST). About 500 adults will be followed for 12 months to see…

This study tests a program called Inspire HER, designed to help Black women improve their heart health through education, physical activity, and social support. Researchers will enroll 90 Black women aged 30-79 with heart, kidney, or metabolic conditions in the Birmingham, AL are…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and blood sugar control. The goal is to understand if thi…

This study looks at whether whole milk or nonfat milk is better for body composition and heart health in children ages 9 to 12 who have a higher BMI. Researchers will measure body fat, lean muscle, and other health markers over one year. The goal is to help guide healthy milk cho…

This study tests an experimental drug called HDM1005 to help obese adults who do not have diabetes lose weight. About 240 people will receive either the drug or a placebo injection. The main goal is to see how much weight they lose after 22 weeks, and whether the drug is safe.

This study tests whether meal replacements can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and improve blood sugar control. About 20 participants will follow an intensive nutrition program for several weeks. The goal is to see if this approach…

This study tests whether adding a low dose of levothyroxine (a thyroid hormone medication) to a healthy diet and exercise program helps people with obesity lose more weight and keep it off. About 286 adults aged 25-60 with mild to moderate obesity and slightly high thyroid levels…

This study is testing a new single-port robot system for weight loss surgery in 50 overweight or obese adults. The goal is to see if the robot makes the surgery safer and more effective, focusing on weight loss and fewer complications. Participants must have a BMI of 27.5 or high…

This early-stage study tests a new drug called ABBV-295 in 96 adults with obesity. Participants receive multiple injections of the drug or a placebo to check for side effects, how the drug moves through the body, and any weight changes. The goal is to gather safety information be…

This study compares an intensive non-surgical weight loss program—including meal replacements, behavioral support, and medication—with bariatric surgery for adults with severe obesity. Researchers want to see if the non-surgical approach can match surgery in improving health and …

This early-stage study is testing a new drug called HM17321 in healthy and obese adults to see if it is safe and how the body processes it. About 90 participants will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood,…

This study compares two programs designed to reduce heart disease risks in Black women after pregnancy. Researchers will track changes in blood pressure and body weight at 6 weeks and 12 months after delivery. The goal is to find the best way to support heart health and reduce he…

This study tests whether new medications can help children and teens (ages 12 to 17) with obesity or overweight manage their weight long-term. Participants must have tried diet and exercise without enough success. The trial will compare different drugs to see which are safe and e…

This study looks at whether lifestyle changes can help control glaucoma in people who also have obstructive sleep apnea and obesity. Researchers will measure eye pressure, sleep quality, and body measurements in 40 participants. The goal is to see if simple lifestyle corrections …

This study tests a new drug called HDM1005 against an existing weight-loss medication, tirzepatide, in 372 adults with obesity but without diabetes. Participants receive weekly injections for 52 weeks, plus diet and exercise counseling. The main goal is to see how much weight is …

This study tests whether a structured lifestyle program can help Malaysian adults with type 2 diabetes achieve remission—meaning blood sugar returns to normal without needing diabetes medication. 92 participants will be randomly assigned to either the lifestyle program or usual c…

This study tests whether adding a stitch (omentopexy) during sleeve gastrectomy reduces new or worsening heartburn two years after surgery. About 526 adults with obesity will be randomly assigned to get sleeve surgery alone or with omentopexy. Researchers will measure heartburn s…

This study tests if a once-weekly medicine called semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive the drug or a placebo while trying to quit. The goal is to see if the drug helps control appe…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in obese patients with endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare tumor samples taken before and a…

This study aims to help African American adults who don't get enough sleep and have overweight or obesity. Researchers will first talk with community members to understand their sleep habits and then test a program designed to help them sleep longer and be more active. The goal i…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This study tests an experimental drug called ALN-2232, given alone or together with an existing weight-loss medication (tirzepatide), in adults with obesity. The goal is to see if the combination is safe and leads to greater weight loss. About 156 participants with a BMI between …

This early-stage study tests a new medicine called LY4167586 in people with obesity or overweight who are otherwise healthy. The main goal is to check if the drug is safe and how the body processes it after a single dose. About 84 participants will receive either the drug or a pl…

This study tests a new medicine called UBT251 to see if it is safe and helps people with overweight or obesity lose weight. About 333 adults will receive either UBT251 or a placebo (dummy treatment) by chance. The main goals are to check for side effects and measure weight change…

This study looks at whether eating milk polar lipids (a type of fat found in milk) every day can improve cholesterol levels, reduce inflammation, and support gut health in adults with high cholesterol and belly fat. About 130 participants will take part in this early-stage trial.…

This study tests whether partially replacing animal protein with plant protein in the diet can improve blood sugar control in people with type 2 diabetes who are overweight or obese. Over 24 weeks, 146 adults will follow either a plant-based diet or a standard healthy diet. The m…

This study looks at whether losing weight, with or without exercise, can improve walking and emotional well-being in veterans who have had a stroke and are overweight. About 130 people aged 35-85 who had a stroke at least 6 months ago will take part. Participants will join a life…

This study tests whether simple home-based strategies and wearable devices can reduce the negative health effects of evening screen time. Researchers will enroll 30 adults who are overweight, inactive, and spend at least 3 hours of recreational screen time after 5pm. Participants…

This study looks at 150 adults with obesity who stopped taking popular weight-loss drugs (like Wegovy or Mounjaro) because of side effects or not losing enough weight. It compares two options: a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG) that reduces…

This study looks at the best dose of a green dye (indocyanine green) used during repeat weight loss surgery to help surgeons see blood flow. About 108 people with obesity will get different doses of the dye to find the smallest amount that still works well. The goal is to improve…

This study looks at whether changing when you eat can lower disease risk for night-shift nurses and nursing assistants who are overweight. About 180 participants will be split into three groups: one just tracks their diet, another eats only during a 10-hour daytime window, and th…

This study looks at whether taking extra iron pills after sleeve gastrectomy surgery can prevent iron deficiency anemia better than a standard multivitamin alone. About 66 adults having the surgery will be split into two groups: one gets an extra daily iron pill plus a multivitam…

This study tests a family-centered program to help Hispanic families lose weight and prevent obesity. Over 1,300 parents and their children ages 8-12 will receive text messages and support to build healthy habits. The goal is to find the best way to help families achieve lasting …

This study tests a program called Healthy Family Foundations for military couples expecting their first child. The program includes 10 online group classes (5 before birth and 5 after) to help parents work together on healthy eating, activity, and parenting. Researchers want to s…

This study tests whether using a special lung-monitoring device (EIT) to set the ventilator during surgery can reduce lung complications like pneumonia or respiratory failure in people having laparoscopic gastric sleeve surgery. About 118 obese adults will be randomly assigned to…

This study looks at whether using a sit-stand desk at work can help prevent type 2 diabetes in people who are overweight and sit most of the day. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours daily at their desk, or to a c…

This study tests whether eating a Mediterranean diet during pregnancy can prevent allergies in children. Researchers will enroll 276 healthy pregnant women who are at risk of having a baby with allergies. Half will follow a Mediterranean diet, and the other half will eat as usual…

This study tests a web and mobile program called Healthy Together ("Juntos") designed for Hispanic teens and their parents. The goal is to prevent unhealthy weight gain and improve physical activity and diet. About 750 families will take part, with teens aged 12-15 who are not cu…

This study tests a 6-month virtual dietary education program (PEDALL) to prevent overweight and obesity in children and teens (ages 5-21) with acute lymphoblastic leukemia (ALL) during maintenance chemotherapy. The program is offered in English and Spanish and aims to keep partic…

This study is testing whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. Researchers will compare a weight loss program to general health education in 81 adults with Down syndrome who are overweight but do not have dementia. The stud…

This study tests whether tradipitant can reduce nausea and vomiting caused by popular weight-loss drugs (GLP-1 agonists) in 280 overweight or obese adults. Participants will receive either tradipitant or a placebo and track their symptoms daily. The goal is to help people stick w…

This study tests whether a type of counseling called acceptance and commitment therapy (ACT) can help people who had weight-loss surgery stay physically active and avoid regaining weight. About 164 adults who had surgery 6-20 months ago will join either ACT or an education progra…

This study tests whether training the muscles used for breathing can improve exercise tolerance in obese women who have finished treatment for early-stage breast cancer. Researchers will measure how long participants can exercise before getting tired. The goal is to find a simple…

This study tests a telehealth program for cancer survivors who smoke, are overweight, or don't get enough exercise. About 1,500 people will either get support through telehealth sessions or just receive information. The goal is to see if the program helps them make lasting health…

This study tests a once-weekly medicine called eloralintide in 800 adults with moderate-to-severe sleep apnea who are also overweight or have obesity. The goal is to see if it can improve breathing during sleep and help with weight loss. Some participants use a CPAP machine, whil…

This study tests if special workshops can help people with obesity cope with hurtful stereotypes and feel more confident. About 210 adults with a BMI over 30 will join a 12-month program with exercise and social support groups. Researchers will check if these workshops improve ho…

This study tests a once-weekly injection called NNC0487-0111 in 400 adults with overweight or obesity and knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain and stiffness compared to a placebo. Participants are randomly assigned to receive …

This study tests whether adding the antibiotic minocycline to usual antidepressants can help people who have both obesity and treatment-resistant depression. Researchers believe that inflammation may play a role in these conditions, and minocycline can reduce inflammation. The st…

This study tests a new once-weekly injection (NNC0487-0111) to see if it helps people with excess weight and knee osteoarthritis lose weight and feel less knee pain. About 400 adults will receive either the study drug or a placebo for comparison. The main goals are to measure wei…

This early-stage study is testing a new medicine called NNC6989-0001 to see if it is safe for healthy people who are overweight or have obesity. About 96 participants will receive either the drug or a placebo by chance. The main goal is to check for any side effects and how the d…

This study is testing a program that helps people with obesity who are waiting for a kidney transplant lose weight. The program includes education on healthy eating and tools to make better lifestyle choices. About 30 adults will take part to see if the program improves their qua…

This study tests whether short, one-minute bursts of exercise (called 'exercise snacks') can improve heart and lung fitness in adults with obesity. Researchers will enroll 80 inactive adults aged 35-64 with a BMI of 30-45. Participants will use a smartphone app to track their exe…

This study tests two ways to strengthen the staple line during weight-loss sleeve surgery: using a medical glue (cyanoacrylate) or a piece of the patient's own abdominal tissue (omentum). The goal is to see which method better prevents complications like bleeding, pain, or leaks …

This study tests whether a special ultrasound-guided nerve block (M-TAPA) can reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy, a common weight-loss surgery. About 60 adults having this surgery will either receive the block or standard care. T…

This study tests whether a virtual reality walking program at home is feasible and helpful for children aged 6 to 17 with conditions like cerebral palsy, neuromuscular diseases, or obesity. Participants use a special treadmill and VR headset for about 30 minutes, three times a we…

This study tests a medicine called cagrilintide to see how it changes appetite and how much people eat. About 120 adults with overweight or obesity will get either the drug or a placebo for around 30 weeks. The main goal is to measure the change in total calories eaten during mea…

This study tests if applying special elastic tape to the chest can improve lung function, breathing muscle strength, and sleep quality in people who are overweight or have mild to moderate obesity. Researchers will measure breathing tests and sleep quality in 36 adults before and…

This early-stage study tests a new medicine called SHR-2906, given as an injection, to see if it is safe and how the body processes it. The study involves 124 people: healthy volunteers receiving a single dose, and obese patients receiving multiple doses. The main goal is to chec…

This early-stage study tests a new nasal spray form of semaglutide (a drug used for weight loss) in 60 overweight or obese adults. The main goal is to check safety and how the drug moves through the body, not yet to prove weight loss. Participants receive a single dose and are mo…

This study tests if a special nerve block (phrenic-sparing) can reduce early breathing problems after shoulder surgery in adults with obesity, compared to the standard block. About 68 participants will be randomly assigned to receive one of the two blocks. Researchers will check …

This study looks at whether lifestyle changes can improve dry eyes in obese women with Polycystic Ovary Syndrome (PCOS). Researchers will measure eye dryness using tests and questionnaires before and after the lifestyle program. The goal is to see if weight loss and healthy habit…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and obesity, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks while researchers monitor side…

This study looks at whether taking N-acetylcysteine (NAC), an antioxidant supplement, can improve the effects of high-intensity interval training in adults with overweight or obesity. Researchers will measure changes in body composition, fitness, and markers of inflammation and o…

This study looks at whether a negative pressure wound therapy device (a kind of vacuum dressing) can improve healing of the belly incision in obese patients who have breast reconstruction using tissue from their abdomen. About 80 participants will be randomly assigned to get eith…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This early-stage study is testing a new injectable drug called LY3971297 to see if it is safe and how the body processes it. The trial includes healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. Researchers will monitor side e…

This study tests a special lifestyle program for women ages 18-25 with a BMI between 25 and 50. The goal is to see if it helps reduce body fat, waist size, and signs of inflammation better than standard weight loss advice. Participants will be followed for 12 months to track chan…

This early-stage study tests whether a once-weekly injection called NNC0487-0111 can lower how much people with obesity eat and how hungry they feel. About 120 adults aged 18-64 will receive either the drug or a placebo for up to 34 weeks. Researchers will measure changes in tota…

This study tests whether a gentle brain stimulation technique called tDCS can boost the effects of cognitive training to help veterans with obesity. Researchers will measure changes in impulsivity and weight in 124 participants. The goal is to find a new way to support weight man…

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults aged 18-60 will receive either real or fake TDCS sessions three times a week for four weeks, while also following a reduced-calo…

This early-stage study is testing a new drug called RT-114 in 60 healthy volunteers to see if it is safe and how the body processes it. The drug is given as a shot or an oral pill, and some participants will receive a placebo. The goal is to gather initial safety data before test…

This study looks at whether an 8-week Pilates exercise program can improve breathing in overweight and obese women. About 48 women will be split into an exercise group and a control group. Researchers will measure lung function, breathing rate, and quality of life before and afte…

This early-stage study tests a new medicine called LY4086940 in healthy people and those who are overweight or have obesity, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in differ…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can reduce the number and severity of hot flashes in women after menopause who also have obesity. Researchers will also check if the drug affects biological aging markers. About 40 women aged 46-60…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for it. The app uses proven strategies to improve self-control and eating habits. For 16 weeks, 50 teens will use the app and share their thoughts on how hel…

This study compares two types of weight-loss surgery—robotic and laparoscopic sleeve gastrectomy—to see which causes less pain the day after surgery. About 91 adults who qualify for weight-loss surgery will be randomly assigned to one of the two procedures. The main goal is to me…

This study tests whether avoiding opioids during and after obesity surgery can improve recovery and reduce side effects. About 220 adults having laparoscopic obesity surgery will be randomly assigned to opioid-free care (with or without personalized support) or standard opioid-ba…

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study is testing whether a weekly injection called retatrutide can help reduce chronic low back pain in adults who have obesity or are overweight. The 80-week trial will compare the drug against a placebo in 586 participants to see if it improves pain and leads to weight los…

This study is for teens and young adults aged 12 to 24 who are planning to have weight loss surgery (sleeve gastrectomy). Researchers want to understand how the body changes after surgery and why some people lose more weight than others. For those who haven't lost enough weight 1…

This study looks at two ways of giving a test meal to healthy adults: one where everyone gets the same number of calories, and one where the calories are adjusted based on a person's body size. Researchers want to find out which method leads to more consistent blood sugar results…

This study aims to find out why some people succeed at losing weight and keeping it off while others struggle. Researchers will look at factors like blood sugar, metabolism, genetics, and body fat in 3200 adults. The goal is to move away from a one-size-fits-all approach to weigh…

This study aims to understand how GLP-1 based weight loss medications change muscle and bone in people with obesity. Researchers will compare a group that also follows a diet and exercise program to a group that only gets standard exercise and diet advice. The results will help d…

This study follows up on mothers and their 14-year-old children from a previous trial where pregnant women with obesity were given a low-calorie diet and exercise program. Researchers want to see if these lifestyle changes during pregnancy can reduce the risk of obesity in the ne…

This study is testing whether a program of eating walnuts and doing moderate exercise before cancer treatment is practical and acceptable for American Indian patients. Researchers will also measure markers of inflammation in blood and tumor tissue to see if the program has an eff…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cylindrical cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section…

This study aims to understand why fat tissue in the belly area doesn't respond normally to signals that release fat for energy. Researchers will measure how fat is released from different parts of the body in 24 adults with and without obesity. Participants will receive infusions…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over two years in 70 South African women. The goal is to understand why obesity raises the risk of …

This study looks at whether a single dose of apple cider vinegar can change levels of a substance called malondialdehyde (a marker of oxidative stress) in the blood of adults with obesity after a meal. Researchers will compare two groups: one that eats a standard meal with apple …

This study looks at how two weight-loss drugs, BI 456906 and semaglutide, attach to receptors in the liver and pancreas. About 30 adults with obesity will get either drug for 17 weeks. Before and after treatment, doctors use PET and MRI scans to see how much the drugs occupy thes…

This early-stage study tests an experimental drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check if the drug is safe and how it interacts with common statins (pitavastatin and rosuvastatin). Participants will receive either the drug or a pl…

This study aims to understand how the body regulates weight by observing 12 people with low weight or obesity during a 2-day fast followed by 2 days of unrestricted eating. Participants stay in special metabolic chambers that measure energy use and intake. The results will help d…

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to support future studies, not to test a treatment directly.

This study tests whether restricting food intake to a 9-hour window each day, without changing what or how much you eat, can improve heart and metabolic health. Researchers will study 100 adults with obesity and prediabetes over 12 weeks. The goal is to see if this eating pattern…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study looks at whether overweight girls start puberty earlier than normal-weight girls. Researchers will use breast and pelvic ultrasounds, blood and urine tests, and X-rays to measure body fat and bone maturity. The goal is to understand if early breast development in overw…

This study looks at how problems with thinking skills (called executive dysfunction) affect physical performance and overall well-being in 100 adults with obesity. Participants will take thinking tests and physical tests like walking speed and grip strength. The goal is to unders…

This study looks at how tiny particles released by cells, called extracellular vesicles, affect blood flow in people with type 2 diabetes. Researchers want to understand if exercise can change these particles to improve blood vessel health. The study involves 60 adults aged 30-80…

This study is following 1,000 people who are having weight-loss (bariatric) surgery to see how their bodies change over two years. Researchers will measure weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits. The goa…

This study compares two ways of using a breathing machine during weight-loss surgery in 40 adults with obesity. The goal is to see which method keeps oxygen levels higher and puts less pressure on the lungs. Results may help doctors choose safer ventilation for future surgeries.

This study looks at whether blocking certain nerve signals for two weeks can improve how the body produces and uses sugar in people with obesity and high blood pressure. Twelve adults will be randomly assigned to receive either a placebo, a blood pressure drug (amlodipine), or a …

This study creates a registry to collect information on endoscopic bariatric therapies (EBTs), which are non-surgical procedures for weight loss. Researchers will review medical charts and follow up to 9,999 participants for one year to measure weight changes and track any side e…

This study looks at why people with lower incomes often have a harder time losing weight in behavioral programs. Researchers will track daily experiences and decision-making patterns in 230 adults with obesity. The goal is to uncover the hidden reasons behind these disparities, n…

This study looks at how two common weight loss methods—newer medications like semaglutide and gastric bypass surgery—affect muscle, metabolism, and side effects. Researchers will follow 60 adults with severe obesity for one year, using body scans and surveys to track changes. The…

This study looks at whether starting with a low-carb diet and then switching to low-fat helps people lose more body fat than the opposite order. Over 8 weeks, 42 overweight adults will eat specially prepared meals at home and have body scans and metabolism tests. The goal is to s…

This study follows up to 150 people with MEHMO syndrome or related disorders to learn how the disease progresses. Researchers will collect blood, urine, spinal fluid, and skin samples, along with imaging and health checks. The goal is to find biological markers that could help di…

This study looks at how to give the right dose of acyclovir to people with obesity. Researchers will measure lean body mass using a special scan to see if it helps predict how the drug is cleared by the kidneys. The study includes 20 healthy volunteers with different body sizes, …

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study looks at how body composition (like weight and body shape) relates to airway stiffness and breathing test results in people with asthma or breathing problems. Researchers will use a device called an oscillometer to measure airway resistance. The goal is to understand i…

This study looks at how the body processes cortisol (a stress hormone) and bile acids (digestive fluids) in obese women before and after gastric bypass surgery. Researchers want to understand why these changes happen and how they might help with weight loss and metabolic health. …

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study looks at how a new drug (NNC0662-0419) changes the way the body processes birth control pills and a common painkiller in women who are overweight or obese and cannot become pregnant. About 45 women will receive all three treatments in sequence to measure drug levels an…

This study aims to understand how obesity and aging are connected by looking at blood-based aging markers in 650 adults. Participants include young (18-35) and older (60+) people who are either lean or overweight. The goal is to find clues that could lead to future treatments or …

This study looks at why obesity damages small blood vessels in muscle, leading to health problems like heart disease. Researchers will measure harmful molecules and blood flow in the muscles of 25 obese adults before and after an 8-week exercise program. The goal is to understand…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood. These particles help cells talk to each other and may influence heart and brain health. Researchers will compare blood samples from 8 healthy adults before …

This study aims to learn more about brown fat, a type of body fat that burns energy and may help control metabolism. Researchers will collect small fat samples from 40 healthy adults during planned surgeries. The goal is to understand how brown and white fat differ at the cellula…

This study looks at how fat tissue and gut bacteria might affect memory and thinking in people with obesity. Researchers will analyze tissue, blood, and gut samples from 100 adults scheduled for surgery. The goal is to find new ways to diagnose and treat brain problems linked to …

This study looks at how fasting insulin and insulin resistance (HOMA-IR) differ based on age, sex, race/ethnicity, body mass index (BMI), and whether someone has polycystic ovary syndrome (PCOS). Researchers will analyze data from 150 adults who recently had metabolic blood tests…

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat makes muscles less responsive to insulin and causes inflammation, and if weight loss can reverse that. About 70 adults with obesity will follow a 12-…

This study looks at whether a ketogenic diet can increase the number of calories your body burns each day and help manage hunger during weight loss maintenance. Researchers will enroll 20 adults with obesity who have lost weight. Participants will stay in a special room that meas…

This study looks at how what children eat affects their growth and development in remote farming communities in Swat, Pakistan. Researchers will follow 832 children from birth to age 5, measuring their height, weight, head size, and developmental skills. The goal is to understand…

This study aims to find rare genetic changes that cause severe obesity starting before age 6. Researchers will enroll 500 children and adults with a very high BMI, collect saliva or blood for genetic testing, and ask about health and eating habits. Family members may also join. T…

This study looks at how being obese changes your DNA and harms blood vessels. Researchers want to see if 12 weeks of aerobic exercise can reverse these changes. 80 adults scheduled for weight-loss surgery will take part. The goal is to understand the body's inner workings, not to…

This study looks at bone health in 120 teens and young adults (ages 12-21) with obesity over 2 years. Some take GLP-1 weight-loss drugs, others use lifestyle changes. Researchers measure bone density and strength to see if the drugs affect bones differently. Participants also tak…

This study looks at how being overweight or obese in midlife (ages 40-60) might increase the risk of Alzheimer's disease. Researchers will use brain scans and blood tests to compare three groups: metabolically healthy lean people, metabolically healthy overweight/obese people, an…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study looks at 8,000 obese young adults in China to find out how genes and other factors contribute to obesity and related health problems like metabolic syndrome. Participants must have a BMI of 30 or higher and be from eastern China. The goal is to learn more about the cau…

This study looks at how changing what you eat—like the amount of protein, fat, carbs, and total calories—affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 24-hour periods…

This study looks at tiny particles released by fat cells, called adipocyte-derived extracellular vesicles (Ad-EVs), and how they relate to blood vessel function in people with obesity. Researchers will compare normal-weight and obese adults, then test whether weight loss improves…

This study looks at how growth hormone affects beta-cells—the cells that make insulin—in women who had gestational diabetes. Researchers want to understand why some women develop this condition. The study involves 30 women with or without a history of gestational diabetes, and us…

This study looks at why some ultra-processed foods (like those high in fat or sugar) make people want to eat more. Researchers will measure cravings, mood, and calorie intake in 50 adults with obesity after they eat different snack foods. The goal is to understand which ingredien…

This study looks at whether resistance training (like lifting weights) can improve how fat is broken down in obese postmenopausal women who have prediabetes. Researchers will measure fat metabolism before and after 12 weeks of training. The goal is to find a practical way to prev…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at how 12 weeks of endurance exercise changes fat tissue quality and insulin sensitivity in 70 men and women with obesity (BMI 30-40). Participants will either exercise or not, and researchers will take small fat samples before and after to measure new fat cell f…

This study follows 320 people who had omega gastric bypass surgery 8-12 years ago to compare long-term side effects of two different loop lengths. The goal is to see which type causes fewer serious problems like hospital stays or disabilities. Results will help doctors choose saf…

This study looks at how time restricted eating (eating only during a 6-hour window each day) affects metabolism and immune function in healthy women aged 18 to 50. Participants will stay in the clinic for 5 days, follow the eating schedule, and undergo tests like blood draws and …

This study follows up with people who previously received the experimental obesity drug INV-347 in an earlier study. Participants will not receive any new treatment. The goal is to track any side effects and measure how long the drug stays in the body. About 91 adults aged 18 and…

This study tests whether adding beans to the diet can improve gut health and metabolism in overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink a bean smoothie daily for two weeks, and researchers will measure changes in gut bacteria, blood ma…

This study is testing a digital program (website and mobile app) to help Hispanic women who have survived breast, uterine, or ovarian cancer, along with their adult daughters, become more active and eat healthier. The goal is to see if the program is easy to use and liked by part…

This study aims to understand why fat tissue in the belly area does not respond to insulin the same way as fat in other parts of the body. Researchers will measure how fat is released from different areas in overweight and lean adults. The findings may help explain why some peopl…

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to temporarily change brain activity in healthy adults. Researchers want to learn how a part of the brain called the cerebellum helps control feelings of fullness after eating. 150 partic…

This study looks at how popular weight-loss drugs (GLP-1 receptor agonists) affect muscle mass and physical function in people with obesity, and whether adding exercise helps. Researchers will follow 40 participants for 2 years, measuring muscle, strength, and metabolism. They al…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study looks at fat tissue from older adults to see how cells change with age and obesity. Researchers will take small fat samples and use advanced genetic tools to map different cell types. Some older participants will also try lifestyle changes or a drug that targets aging …

This study is following 2,800 pregnant women and their children in Weifang, China, to see how things like diet, environment, and lifestyle during pregnancy affect health for both mother and child. Researchers will track pregnancy complications, birth outcomes, and child developme…

This study looks at how eating and sleeping at mismatched times (like shift workers or jet lag) affects body weight. Researchers will measure energy use, body composition, and brain responses in 42 adults. The goal is to understand how timing, not just what you eat, impacts weigh…

This study looks at how lactate, a fuel for brain cells, influences brain blood flow in people with and without obesity. Researchers will measure blood flow and lactate levels during exercise in 24 healthy adults. Only those with obesity will do short-term exercise training to se…

This study tests an experimental drug called MKP10241 in healthy adults and people with obesity, with or without type 2 diabetes. The main goals are to see if food changes how the drug works, how safe it is, and how the body processes it. About 68 participants will take either th…

This study looks at whether certain fats made from dietary fatty acids are linked to breast cancer and body weight in postmenopausal women. Researchers will compare four groups of women (healthy or with breast cancer, and with normal weight or overweight/obesity) to measure these…

This study compares two training programs for doctors and health workers at community health centers that serve Medicaid patients. The goal is to see which training helps patients lose more weight and get better access to obesity care. About 6,200 patients and their providers wil…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at whether eating sunflower oil rich in oleic acid (a healthy fat) can change how fat cells handle cholesterol in women with obesity. About 40 women scheduled for weight-loss surgery will take either the special oil or regular sunflower oil for 13 weeks. Research…

This study looks at how two different anesthesia methods affect stress during weight-loss surgery. About 70 adults having sleeve gastrectomy or gastric bypass will receive opioid-free anesthesia, some with and some without the gas desflurane. Researchers will measure stress hormo…

This study looks at whether people with obesity who also have binge eating or food addiction experience taste differently than those without these behaviors. Researchers will measure sweet and salty taste thresholds in 300 participants. The goal is to understand why some people o…

This study aims to understand the heart health of adults in Black church communities in Washington D.C. Researchers will measure things like blood pressure, cholesterol, and weight, and ask about lifestyle habits. Participants will also wear activity monitors for a month. The inf…

This study looks at stomach tissue from 100 obese adults undergoing weight-loss surgery and compares it to normal tissue. Researchers want to see if certain immune cells and blood vessel changes in the stomach are early signs of cancer risk. No treatment is given—this is an obser…

This study will check how often muscle loss (sarcopenia) happens in 300 adults with obesity. Researchers will measure muscle mass, strength, and physical function, and look at factors like age, diet, and activity. The goal is to help doctors better identify and manage this condit…

This study looks at how the bacteria in your gut might talk to your brain, affecting your ability to control eating. Researchers will compare 116 adults with and without obesity using brain scans, memory tests, and gut bacteria analysis. The goal is to understand why some people …

This study looks at whether breathing limitations make it harder for people with heart failure and obesity to exercise. Researchers will measure how much oxygen breathing takes and if special gas mixtures help with shortness of breath and exercise ability. About 78 adults aged 55…

This study looks at why insulin fails to properly control fat breakdown in people with upper body obesity. Researchers will test how the diabetes drug pioglitazone affects fat cell proteins compared to a placebo. The study involves 64 adults, both non-obese and obese, to understa…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study aims to better understand heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect medical information, images, and samples from up to 5,000 participants, including healthy volunteers and family members. The goal is to …

This observational study explores how hormones in a mother's blood and breast milk relate to her baby's growth, body fat, and eating behavior. Researchers will compare mothers who had a normal weight before pregnancy with those who were overweight or obese. The study involves 130…

This study looks at how a natural heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will compare people with a common genetic variation that lowers ANP levels to those with normal levels. Participants will undergo exercise and …

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. They will measure insulin sensitivity, fitness, and overall health to understa…

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide for eight days to temporarily stop the pancreas from making insulin. Researchers will measure fasti…

This study looks at whether taking a daily supplement called SPM Active® for 12 weeks can increase certain omega-3-related substances in the blood and improve well-being in adults with obesity. About 33 people aged 45-60 with a BMI between 30 and 40 will take two soft-gel capsule…

This study looks at how GLP-1 medications (like Ozempic) change fat tissue in people having weight-loss surgery. Researchers will measure oxytocin levels and fat quality in 40 patients, comparing those who took GLP-1 drugs for at least 3 months to those who did not. The goal is t…

This study looks at how long you need to fast and whether temporarily stopping GLP-1 medications (like liraglutide or semaglutide) affects how much food stays in your stomach. Researchers will study 75 adults with obesity who already take these drugs. The goal is to improve safet…

This study looks at tiny particles released from fat tissue, called extracellular vesicles, to understand how obesity leads to insulin resistance in muscles. Researchers will compare these particles in lean and obese people, and also check for differences between men and women. T…

This study works with clinics in Massachusetts to offer proven programs for weight management, cancer screening, and mental health to adults in underserved areas. Researchers will track changes in body mass index, cancer screening rates, and mental health scores. The goal is to r…

This study aims to find new biological clues that explain why some people with severe obesity develop type 2 diabetes while others do not. Researchers will collect tissue samples (fat, muscle, liver, blood) from 270 adults during planned weight-loss surgery. By comparing samples …

This study looks at whether robot-assisted weight-loss surgery is worth its higher cost compared to standard laparoscopic surgery. About 482 adults with obesity will be randomly assigned to one of the two methods. Researchers will track complications, quality of life, and overall…

This study looks at how people with obesity feel about their quality of life after a less invasive stomach procedure called endoscopic vertical gastroplasty (GVE). Researchers will interview 20 Italian adults who had the procedure at least six months ago. The goal is to understan…

This study is testing a new, ultra-thin endoscope that can be inserted through the nose without sedation to examine the upper digestive tract in people with obesity. The goal is to see if this approach is more comfortable, safer, and cheaper than traditional endoscopy. About 100 …

This early-stage study looks at how a new weight-loss drug, maridebart cafraglutide (AMG 133), changes the way the body processes oral contraceptives. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth contr…

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …

This study aims to identify factors that predict how much weight people lose after a procedure called endoscopic sleeve gastroplasty, a less invasive stomach surgery for obesity. Researchers will follow 205 adults with obesity (BMI 30-35 with complications, or over 35 if surgery …

This study follows 5,000 children in a park-based afterschool program to see if it improves their physical fitness, weight, and mental health. Researchers will measure changes in body measurements, fitness tests, and questionnaires about anxiety and well-being. The goal is to und…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food or drink left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal is …

This study aims to see if a specially designed education module helps people with spinal cord injuries learn about their increased risk for heart disease, obesity, and related conditions. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure their kn…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to healthy-weight individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants over 18. The goal is …

This study looks at how a park-based fitness program affects the health of adults aged 50 and older in Miami-Dade County. Researchers will measure changes in weight, blood pressure, strength, and mobility in 1,000 participants. The goal is to see if community park programs can he…

This study looks at how diet affects gum health in 200 adults with obesity but no other health problems. Researchers will calculate each person's dietary inflammatory index (DII) score and measure markers of inflammation in their gum fluid and blood. The goal is to see if a pro-i…

This study looks at how a type of diabetes medicine (GLP-1 receptor agonists) affects fat tissue function in people with chronic kidney disease. Researchers want to see if improving fat health can slow kidney damage. About 250 adults with early-to-moderate kidney disease, obesity…

This study looks at whether bariatric surgery can slow or reverse biological aging in people with obesity. Researchers will measure changes in blood markers, fat cells, and gut bacteria before and after surgery. The goal is to understand how weight-loss surgery affects the body's…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This early-stage study is testing a single dose of an experimental medicine called PF-08653944 in 54 overweight or obese adults. The goal is to see how the drug is absorbed when injected into the thigh, upper arm, or abdomen. Researchers will also monitor safety through blood tes…

This study checks if two different versions of the drug survodutide are absorbed the same way in the body. It involves 80 healthy adults who are overweight or obese. Participants will receive both formulations at different times to compare drug levels in the blood.

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans and physical tests to see how the drug affects muscle mass and function. The goal is to understand risks of muscle loss an…

This study is testing an experimental drug called angiotensin-(1-7) to see if it can improve how blood vessels and nerves work in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery size during a short infusion of the drug comp…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study follows 930 young people aged 12 to 25 over up to 25 years to learn how type 2 diabetes affects heart and blood vessel health. Participants include those with diabetes, overweight but not diabetic, and healthy lean individuals. They will have yearly 4-day visits with t…

This study looks at how high-intensity interval training (HIIT) changes brain activity and appetite in people who regained weight after bariatric surgery. Researchers will use brain scans and questionnaires to understand the connection between exercise, brain function, and weight…

This study is testing a special care program for adults with obesity. The program offers coordinated support and education to help patients become more active in their own care. Researchers want to see if this approach improves patients' sense of self-efficacy—their belief in the…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women aged 18-70. Researchers will measure body fat, blood fats, and insulin function to find out why heart disease risk factors differ between African Americans and C…

This study looks at how different types of food affect what we choose to eat later. Researchers will give participants two different liquid meals—one high in carbs, one high in protein—and see how that changes their food choices at a buffet. The goal is to understand if people wi…

This study tests whether a simple, home-based breathing exercise program can improve brain function and reduce inflammation in adults with obesity. Researchers will measure changes in blood flow to the brain and immune system activity before and after 8 weeks of training. The goa…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that control sugar and fat metabolism. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more abou…

This study aims to understand how genes and the environment shape children's eating behavior and health over time. Researchers will follow 1,500 children ages 8-17 for up to 6 years, using wrist monitors, smartphone surveys, and yearly checkups that include blood tests, X-rays, a…

This study looks at how a low-carbohydrate diet and a supplement called nicotinamide riboside (NR) change the way the body burns fat and uses energy. Researchers will study 100 overweight or obese adults, including some with a specific type of diabetes. Participants will stay in …

This study aims to understand why night shift workers are more likely to become obese. Researchers will compare 1,000 shift and day workers from five European countries. They will look at diet, sleep, and body samples to find the biological and behavioral reasons behind weight ga…

This study looks at how body weight relates to women's bathroom habits, genital hygiene, and bladder symptoms. Researchers will compare normal-weight and overweight/obese women aged 18-45 using questionnaires. The goal is to understand these connections and improve quality of lif…

This study aims to understand how the brains and metabolisms of people with obesity react differently to sugar, fat, and protein compared to people without obesity. Researchers will give 60 participants liquid meals and use brain scans and blood tests to measure their responses. …