New pill aims to stop nausea caused by popular Weight-Loss drugs

NCT ID NCT07446439

Recruiting now Symptom relief Sponsor: Vanda Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tests whether tradipitant can reduce nausea and vomiting caused by GLP-1 weight-loss drugs. About 280 healthy overweight or obese adults will receive either tradipitant or a placebo. The goal is to see if tradipitant helps people tolerate these medications better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tradipitant (oral capsule)
What this could lead to: If it works, this could offer a way to manage nausea and vomiting for people taking GLP-1 weight-loss medications, making them easier to tolerate.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not reduce symptoms better than a placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Nausea Obesity obesity disorder Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAUSEA AND VOMITING OBESITY

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Vanda Investigational Site
RECRUITING

Los Angeles, California, 90025, United States
Vanda Investigational Site
RECRUITING

San Diego, California, 92108, United States
Vanda Investigational Site
NOT_YET_RECRUITING

San Jose, California, 95124, United States
Vanda Investigational Site
RECRUITING

Tampa, Florida, 33613, United States
Vanda Investigational Site
NOT_YET_RECRUITING

Hamilton, New Jersey, 08690, United States
Vanda Investigational Site
NOT_YET_RECRUITING

New York, New York, 10016, United States
Vanda Investigational Site
NOT_YET_RECRUITING

Syosset, New York, 11791, United States
Vanda Investigational Site
NOT_YET_RECRUITING

Plano, Texas, 75024, United States
Vanda Investigational Site
NOT_YET_RECRUITING

San Antonio, Texas, 78215, United States
Vanda Investigational Site
NOT_YET_RECRUITING

Burke, Virginia, 22015, United States

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