Gastric bypass showdown: which surgery cures diabetes best?

NCT ID NCT03821636

Recruiting now Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two versions of Roux-en-Y gastric bypass surgery to see which one is better at putting type 2 diabetes into remission in severely obese patients. The trial will enroll 396 people with a BMI of 35 or higher and type 2 diabetes. Participants will be randomly assigned to receive either a long alimentary limb or a long biliary limb bypass, and researchers will measure diabetes remission rates along with weight loss and complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Roux-en-Y gastric bypass surgery (two variants: long alimentary limb or long biliary limb)
What this could lead to: If successful, this could show that a specific type of gastric bypass surgery is more effective at putting type 2 diabetes into remission for severely obese patients.
What could go wrong: This is a surgical trial with inherent risks like infection or bowel obstruction. The results may not apply to all patients, and diabetes remission may not be permanent.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS TYPE 2 IN OBESE

Contacts and locations

Locations

Ch Boulogne-Sur-Me
RECRUITING

Boulogne-sur-Mer, 62321, France
Ch de Valenciennes
RECRUITING

Valenciennes, France
Chu Amiens Picardie
RECRUITING

Amiens, France
Hop Claude Huriez Chu Lille
RECRUITING

Lille, 59037, France

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