New weekly shot could help teens with obesity and related health problems

NCT ID NCT06439277

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests whether a weekly injection of tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity and related conditions like high blood pressure or prediabetes lose weight and improve their health. About 300 teens who completed a prior study can join this 156-week extension. The goal is to see if the drug leads to meaningful weight loss and better control of weight-related health issues.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide (a once-weekly injection)
What this could lead to: If successful, this could provide a long-term treatment option for adolescents with obesity and related health issues like high blood pressure or prediabetes.
What could go wrong: This is an extension study, so results are still preliminary. The drug may cause side effects like nausea or vomiting, and not all participants may see significant benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Weight Gain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY WEIGHT GAIN

Contacts and locations

Locations

Addenbrooke's Hospital
ACTIVE_NOT_RECRUITING

Cambridge, CB2 0SL, United Kingdom
Alder Hey Children's Hospital
COMPLETED

Liverpool, L14 5AB, United Kingdom
Alliance for Multispecialty Research, LLC
COMPLETED

Layton, Utah, 84041, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universitaire (C -T
ACTIVE_NOT_RECRUITING

Paris, 75019, France
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
ACTIVE_NOT_RECRUITING

Marseille, 13385, France
Bluewater Clinical Research Group Inc.
COMPLETED

Sarnia, N7T 4X3, Canada
CHU de Toulouse - Hôpital des Enfants
COMPLETED

Toulouse, 31059, France
Carmel Hospital
ACTIVE_NOT_RECRUITING

Haifa, 3436212, Israel
Centre Hospitalier Universitaire d'Angers
ACTIVE_NOT_RECRUITING

Angers, 49933, France
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
ACTIVE_NOT_RECRUITING

Buenos Aires, C1425AGC, Argentina
Centro de Atención e Investigación Clínica
ACTIVE_NOT_RECRUITING

Aguascalientes, 20129, Mexico
Centro de Investigacion Medica de Occidente, S.C.
ACTIVE_NOT_RECRUITING

Guadalajara, 44260, Mexico
Centro de Investigaciones Metabólicas (CINME)
ACTIVE_NOT_RECRUITING

Buenos Aires, C1056ABI, Argentina
Centro de Investigaciones Médicas Tucuman
ACTIVE_NOT_RECRUITING

SAN M. de Tucuman, T4000AXL, Argentina
Chang Gung Medical Foundation-Linkou Branch
ACTIVE_NOT_RECRUITING

Taoyuan, 333, Taiwan
Children's Hospital Los Angeles
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90027, United States
China Medical University Hospital
ACTIVE_NOT_RECRUITING

Taichung, 404332, Taiwan
Christus - Latam Hub Center of Excellence and Innovation S.C.
ACTIVE_NOT_RECRUITING

Monterrey, 64060, Mexico
Clínica García Flores SC
ACTIVE_NOT_RECRUITING

Monterrey, 64610, Mexico
Consano Clinical Research, LLC
ACTIVE_NOT_RECRUITING

Shavano Park, Texas, 78231, United States
Consultorio Médico de Endocrinología y Pediatría
ACTIVE_NOT_RECRUITING

Puebla City, 72190, Mexico
Cornerstone Dermatology
ACTIVE_NOT_RECRUITING

Coorparoo, 4151, Australia
DIM Clínica Privada
ACTIVE_NOT_RECRUITING

Ramos Mejía, B1704ETD, Argentina
Driscoll Children's Hospital
ACTIVE_NOT_RECRUITING

Corpus Christi, Texas, 78411, United States
Emek Medical Center
ACTIVE_NOT_RECRUITING

Afula, 1834111, Israel
Epic Medical Research - DeSoto
ACTIVE_NOT_RECRUITING

DeSoto, Texas, 75115, United States
Fundación Respirar
COMPLETED

Buenos Aires, C1426ABP, Argentina
H.R.U Málaga - Hospital General
ACTIVE_NOT_RECRUITING

Málaga, 29011, Spain
Hospices Civils de Lyon - Hopital Louis Pradel
ACTIVE_NOT_RECRUITING

Bron, 69677, France
Hospital Infantil Universitario Niño Jesús
ACTIVE_NOT_RECRUITING

Madrid, 28009, Spain
Hospital Universitari Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe
ACTIVE_NOT_RECRUITING

Valencia, 46026, Spain
Hospital Universitario Reina Sofia
ACTIVE_NOT_RECRUITING

Córdoba, 14004, Spain
Hunter Medical Research Institute
RECRUITING

Newcastle, 2305, Australia
Hôpital Armand Trousseau
ACTIVE_NOT_RECRUITING

Paris, 75012, France
Hôpital Jeanne de Flandre
ACTIVE_NOT_RECRUITING

Lille, 59000, France
Indiana University Health University Hospital
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202, United States
Investigaciones Medicas Imoba Srl
ACTIVE_NOT_RECRUITING

Buenos Aires, C1056ABH, Argentina
Leeds General Infirmary
ACTIVE_NOT_RECRUITING

Leeds, LS1 3EX, United Kingdom
Leicester Royal Infirmary
COMPLETED

Leicester, LE1 5WW, United Kingdom
Medical Research Partners
ACTIVE_NOT_RECRUITING

Ammon, Idaho, 83406, United States
Meir Medical Center
ACTIVE_NOT_RECRUITING

Kfar Saba, 4428164, Israel
National Cheng Kung University Hospital
ACTIVE_NOT_RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
COMPLETED

Taipei, 10002, Taiwan
Nemours Children's Health - Delaware
ACTIVE_NOT_RECRUITING

Wilmington, Delaware, 19803, United States
Nightingale Research
COMPLETED

Adelaide, 5000, Australia
Paediatric and Adolescent OutpatientsElizabeth Garrett Anderson WingUniversity College Hospital
COMPLETED

London, WC1E 6DB, United Kingdom
Perth Children's Hospital
COMPLETED

Perth, 6009, Australia
Premier Clinical Trial Network
NOT_YET_RECRUITING

Hamilton, L8L5G4, Canada
Rambam Health Care Campus
ACTIVE_NOT_RECRUITING

Haifa, 3109601, Israel
Royal Hospital for Children
ACTIVE_NOT_RECRUITING

Glagow, G51 4TF, United Kingdom
Royal Victoria Infirmary
ACTIVE_NOT_RECRUITING

Newcastle upon Tyne, NE1 4PL, United Kingdom
SUNY Upstate Medical University
ACTIVE_NOT_RECRUITING

Syracuse, New York, 13210, United States
Schneider Children's Medical Center
ACTIVE_NOT_RECRUITING

Petah Tikva, 4920235, Israel
Shaare Zedek Medical Center
COMPLETED

Jerusalem, 9013102, Israel
Sheba Medical Center
ACTIVE_NOT_RECRUITING

Ramat Gan, 5262100, Israel
Sheffield Children's Hospital
ACTIVE_NOT_RECRUITING

Sheffield, S10 2TH, United Kingdom
Soroka Medical Center
ACTIVE_NOT_RECRUITING

Beersheba, 8410101, Israel
Southampton General Hospital
COMPLETED

Southampton, SO16 6YD, United Kingdom
Sutter Valley Medical Foundation (SVMF) Pediatric Endocrinology
ACTIVE_NOT_RECRUITING

Sacramento, California, 95821, United States
Texas Valley Clinical Research
ACTIVE_NOT_RECRUITING

Weslaco, Texas, 78596, United States
UBMD Pediatrics
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14203, United States
Universitaetsklinikum Koeln
ACTIVE_NOT_RECRUITING

Cologne, 50937, Germany
Universitaetsklinikum Ulm
ACTIVE_NOT_RECRUITING

Ulm, 89075, Germany
University Pediatric Hospital
COMPLETED

San Juan, 00935, Puerto Rico
University of Sydney - Charles Perkins Centre
ACTIVE_NOT_RECRUITING

Sydney, 2006, Australia
Universitätsklinikum Leipzig
ACTIVE_NOT_RECRUITING

Leipzig, 04103, Germany
Valley Institute of Research - Fort Worth
ACTIVE_NOT_RECRUITING

Fort Worth, Texas, 76164, United States
Winterberry Research Inc.
RECRUITING

Hamilton, L8J 0B6, Canada

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