WEIGHT GAIN

This study tests whether a weekly injection of tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity and related conditions like high blood pressure or prediabetes lose weight and improve their health. About 300 teens who completed a prior study c…

This study tests two types of distal gastric bypass surgery for people who regained weight or didn't lose enough after an initial Roux-en-Y gastric bypass. About 150 participants will be randomly assigned to one of the two procedures and followed for three years. The main goals a…

This study tests whether a very low dose of semaglutide (a drug used for weight loss and diabetes) can help people with HIV avoid regaining weight after an initial weight-loss period. About 30 adults with HIV who are on stable HIV treatment and are overweight or obese will take p…

This study looks at whether time-restricted eating (eating only during a set window each day) can help adults who have recently lost weight keep it off and avoid regaining fat. About 110 adults aged 25-65 who lost at least 5% of their body weight in the last 3 months will be rand…

This study compares stevia-sweetened drinks, sugary drinks, and flavored water in children ages 8-12 who regularly drink sugary beverages. Over 8 to 14 weeks, researchers will measure changes in weight, body fat, insulin resistance, blood fats, and blood pressure. The goal is to …

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

This study tests four different HIV drug regimens in 120 healthy volunteers to see how they affect metabolism and weight. Participants take one of the drugs or a combination for four weeks, with blood tests, body scans, and optional fat biopsies. The goal is to understand why som…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study is testing whether having groceries delivered can help low-income pregnant young women gain a healthy amount of weight and eat better. About 570 women in early pregnancy will take part. The goal is to learn if this simple support can improve health during pregnancy.

This study looks at whether high-intensity interval training (HIIT) can change how the brain works in people who have regained weight after bariatric surgery. Researchers will use brain scans and questionnaires to measure changes in brain connectivity, appetite, and mood. The goa…