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New drug aims to stop muscle loss while shedding pounds

NCT ID NCT07101939

Recruiting now Disease control Sponsor: Actimed Therapeutics Ltd Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a drug called ACM-001.1 can help obese people keep their muscle while taking semaglutide for weight loss, and help them regain muscle after stopping semaglutide. About 120 participants will receive either ACM-001.1 or a placebo alongside semaglutide, and changes in muscle mass will be measured using DEXA scans. The goal is to find a way to lose fat without losing muscle.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
(S)-pindolol benzoate (ACM-001.1)
What this could lead to
If it works, this could lead to a way to lose weight without losing muscle, and help people regain muscle after stopping weight-loss drugs.
What could go wrong
This is an early phase 2 trial with only 120 people, so results may not apply to everyone. The drug may not work as hoped or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

muscular atrophy Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUSCLE LOSS OBESITY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Clinical Hospital Center 'Dr Dragisa Misovic - Dedinje'

    RECRUITING

    Belgrade, Serbia

  • Clinical Hospital Center Bezanijska kosa

    RECRUITING

    Belgrade, Serbia

  • Klinika Za Endocrinologiju, Dijabetes I Bolesti Metabolizma

    RECRUITING

    Niš, Serbia

  • Opsta bolnica Pancevo

    RECRUITING

    Pančevo, Serbia

  • University Clinical Center Kragujevac

    RECRUITING

    Kragujevac, Serbia

  • University Clinical Center of Serbia

    RECRUITING

    Belgrade, Serbia

  • University Clinical Center of Vojvodina

    RECRUITING

    Novi Sad, Serbia

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