New drug aims to stop muscle loss while shedding pounds
NCT ID NCT07101939
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a drug called ACM-001.1 can help obese people keep their muscle while taking semaglutide for weight loss, and help them regain muscle after stopping semaglutide. About 120 participants will receive either ACM-001.1 or a placebo alongside semaglutide, and changes in muscle mass will be measured using DEXA scans. The goal is to find a way to lose fat without losing muscle.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
(S)-pindolol benzoate (ACM-001.1)
What this could lead to
If it works, this could lead to a way to lose weight without losing muscle, and help people regain muscle after stopping weight-loss drugs.
What could go wrong
This is an early phase 2 trial with only 120 people, so results may not apply to everyone. The drug may not work as hoped or could have side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clinical Hospital Center 'Dr Dragisa Misovic - Dedinje'
RECRUITINGBelgrade, Serbia
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Clinical Hospital Center Bezanijska kosa
RECRUITINGBelgrade, Serbia
Contact
Contact
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Klinika Za Endocrinologiju, Dijabetes I Bolesti Metabolizma
RECRUITINGNiš, Serbia
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Opsta bolnica Pancevo
RECRUITINGPančevo, Serbia
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University Clinical Center Kragujevac
RECRUITINGKragujevac, Serbia
Contact
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University Clinical Center of Serbia
RECRUITINGBelgrade, Serbia
Contact
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University Clinical Center of Vojvodina
RECRUITINGNovi Sad, Serbia
Contact