Could a ketone drink help teens with fatty liver disease?
NCT ID NCT07097506
First seen Jun 24, 2026 · Last updated Jul 16, 2026 · Updated 3 times
Summary
This study tests whether a daily ketone ester drink can reduce liver fat and improve how the body handles sugar in adolescents and young adults with obesity and a fatty liver condition called MASLD. Forty participants will be randomly assigned to receive either the ketone drink or a placebo for six weeks. Researchers will measure changes in liver fat using MRI and check insulin sensitivity with a special test.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester)
- What this could lead to
- If it works, this could point toward a simple dietary supplement to help manage liver fat and blood sugar in young people with obesity-related liver disease.
- What could go wrong
- This is a small, early-phase trial with only 40 participants, so results may not apply widely. The drink might cause digestive discomfort or not improve liver health as hoped.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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