New weekly shot shows promise for major weight loss in major trial

NCT ID NCT07351045

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 2000 adults with obesity or overweight who do not have type 2 diabetes. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see how much weight they lose, with secondary goals looking at how many achieve 5%, 10%, 15%, or 20% weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enicepatide (a weekly injection that mimics natural hormones to help with weight loss)
What this could lead to: If it works, this could provide a new, effective weekly injection for significant weight loss in people with obesity or overweight.
What could go wrong: This is a phase 3 trial, but results are not guaranteed. Side effects from similar drugs include nausea and vomiting, and long-term safety is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OR OVERWEIGHT

Contacts and locations

Locations

A.O. Universitaria Policlinico S.Orsola-Malpighi Di Bologna
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
AZ Delta (Campus Rumbeke)
RECRUITING

Roeselare, 8800, Belgium
AZORG Campus Aalst-Moorselbaan
RECRUITING

Aalst, 9300, Belgium
Affiliated Hospital of Jiangsu University
RECRUITING

Zhenjiang, Jiangsu, 212002, China
Aggarwal and Associates
RECRUITING

Brampton, Ontario, L6T 0G1, Canada
Alabama Clinical Therapeutics
RECRUITING

Birmingham, Alabama, 35235, United States
Alpha Recherche Clinique
RECRUITING

Québec, G2J0C4, Canada
Amsterdam UMC Location AMC
RECRUITING

Amsterdam, 1105 AZ, Netherlands
Anyagcsere Centrum Csepel/Szatmári-Med Kft.;Diabetology
RECRUITING

Budapest, 1213, Hungary
Arechavaleta Granell Maria del Rosario
RECRUITING

Guadalajara, Jalisco, 44650, Mexico
Arizona Clinical Trials
RECRUITING

Tucson, Arizona, 85711, United States
Artemis Institute for Clinical Research, LLC
RECRUITING

San Diego, California, 92123, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Ascension Columbia St. Mary's
RECRUITING

Milwaukee, Wisconsin, 53211, United States
Ascension DePaul Health
RECRUITING

New Orleans, Louisiana, 70127, United States
Avant Santé Research Center
RECRUITING

San Pedro Garza García, Nuevo León, 66260, Mexico
Azienda Ospedaliera Papa Giovanni XXIII
RECRUITING

Bergamo, Abruzzo, 24127, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, Sicily, 90127, Italy
Azienda Ospedaliero-Universitaria "Renato Dulbecco" Catanzaro
RECRUITING

Catanzaro, Calabria, 88100, Italy
BR Trials - Pesquisa Clínica
RECRUITING

São Paulo, São Paulo, 01236-030, Brazil
Baker Heart and Diabetes Insitute
RECRUITING

Melbourne, Victoria, 3004, Australia
Beijing Pinggu Hospital
RECRUITING

Beijing, 101200, China
Bellaire Clinical Research, LLC
RECRUITING

Bellaire, Texas, 77401, United States
Birmingham Heartlands Hospital
RECRUITING

Birmingham, B9 5SS, United Kingdom
Bluewater Clinical Research Group
RECRUITING

Sarnia, Ontario, N7T 4X3, Canada
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Bucheon St Mary's hospital
RECRUITING

Gyeonggi-do, 14647, South Korea
C-health Partners Inc
RECRUITING

Calgary, Alberta, T2V 4J2, Canada
CEDIC Centro de Investigaciones Clinicas
RECRUITING

Buenos Aires, C1060ABN, Argentina
CEMDEC S.A. de C.V.
RECRUITING

Delegacion Cuauhtemoc, Mexico CITY (federal District), 06100, Mexico
CHU DE POITIERS - Hôpital de la Milétrie
RECRUITING

Poitiers, 86021, France
CHU Dijon - Hopital Francois Mitterrand
RECRUITING

Dijon, DUMMY_VALUE, France
CHU d'Angers
RECRUITING

Angers, 49933, France
CHU de Bordeaux;Service d?endocrinologie, diabétologie et nutrition
RECRUITING

Pessac, 33604, France
CHU de Liège (Sart Tilman)
RECRUITING

Liège, 4000, Belgium
CHU de Nantes - Hopital Laennec
RECRUITING

Saint-Herblain, 44800, France
CHU de Rouen - HOPITAL Bois Guillaume
RECRUITING

Bois-Guillaume, 76230, France
CINME
RECRUITING

Buenos Aires, C1056ABI, Argentina
CPQuali Pesquisa Clinica Ltda
RECRUITING

São Paulo, São Paulo, 01228-000, Brazil
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
RECRUITING

Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
Centro Medico Viamonte SRL
RECRUITING

Buenos Aires, C1120AAC, Argentina
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares SC
RECRUITING

Ciudad Madero, Tamaulipas, 89440, Mexico
Centro de Investigaciones Medicas Mar Del Plata
RECRUITING

Mar del Plata, B7600FYK, Argentina
Centro de Pesquisas Clinicas
RECRUITING

São Paulo, São Paulo, 01228-200, Brazil
Centrum Medyczne ALL-MED
RECRUITING

Krakow, 30-033, Poland
Centrum Medyczne Clinicly
RECRUITING

Opole, 45-047, Poland
Centrum Medyczne Kermed Renata Bijata-Bronisz i Ewa Kowali?ska Sp.j.
RECRUITING

Bydgoszcz, 85-231, Poland
Changhua Christian Hospital
RECRUITING

Changhua, 50006, Taiwan
Chia-Yi Christian Hospital
RECRUITING

Chiayi City, 600, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Chosun University Hospital
RECRUITING

Gwangju, 61453, South Korea
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan
Circle Clinical Research
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinical Research Associates
RECRUITING

Nashville, Tennessee, 37203, United States
Clinicos Asociados Bocm, S.C.
RECRUITING

México, Mexico CITY (federal District), 03300, Mexico
Clinvest Research LLC
RECRUITING

Springfield, Missouri, 65807, United States
Consano Clinical Research
RECRUITING

Shavano Park, Texas, 78231, United States
DIALINE s.r.o.
RECRUITING

Plze?, 301 00, Czechia
DRC Gyogyszervizsgalo Kozpont Kft
RECRUITING

Balatonfüred, 8230, Hungary
Debreceni Egyetem, Klinikai Kozpont;Belgyogyaszati Klinika, A epulet
RECRUITING

Debrecen, 4032, Hungary
DelRicht Research at Gulfport Memorial
RECRUITING

Gulfport, Mississippi, 39503, United States
Delricht Research of Tulsa Clinical Trials
RECRUITING

Tulsa, Oklahoma, 74133, United States
DiaVize
RECRUITING

Prague, 140 00, Czechia
Diabeteszentrum Hamburg West
RECRUITING

Hamburg, 22607, Germany
Diabetologische Schwerpunktpraxis Pirna Hausärztliche Versorgung
RECRUITING

Pirna, 01796, Germany
Diablo Clinical Research, Inc.
RECRUITING

Walnut Creek, California, 94598, United States
Diex Recherche Trois-Rivieres
RECRUITING

Trois-Rivières, Quebec, G9A 4P3, Canada
ETG Warszawa
RECRUITING

Warsaw, 02-677, Poland
ETG Zamosc
RECRUITING

Zamo??, 22-400, Poland
East-West Medical Research Institute
RECRUITING

Honolulu, Hawaii, 96814, United States
Edumed s.r.o.;Diabetologická ambulance
RECRUITING

Náchod, 54701, Czechia
Elevate Clinical
RECRUITING

Houston, Texas, 77058, United States
Elevate Clinical
RECRUITING

McAllen, Texas, 78504, United States
Elevate Clinical Research
RECRUITING

Gurnee, Illinois, 60031, United States
Endeavor Health
RECRUITING

Skokie, Illinois, 60077, United States
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz;2nd Department of Internal Medicine, Nephrological and Diabetological Center
RECRUITING

Székesfehérvár, 8000, Hungary
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, Lazio, 00168, Italy
Fukuhama Chuo Clinic
RECRUITING

Fukuoka, 810-0066, Japan
Gabinety Medyczne MATUSZEK
RECRUITING

Lublin, 20-064, Poland
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
George E. Wahlen Department of Veterans Affairs Medical Center
RECRUITING

Salt Lake City, Utah, 841480001, United States
Groupe Hospitalier Pitié Salpétrière;Service d?endocrinologie, diabétologie et nutrition
RECRUITING

Paris, 75671, France
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
RECRUITING

Goiânia, Goiás, 74605-020, Brazil
Hamilton Medical Research Group
RECRUITING

Hamilton, Ontario, L8L 5G4, Canada
Hammersmith Hospital
RECRUITING

London, W12 0HS, United Kingdom
Hanyang University Guri Hospital
RECRUITING

Gyeonggi-do, 11923, South Korea
Hasegawa Medicine Clinic
RECRUITING

Hokkaido, 066-0032, Japan
Headlands Reseach- Summit
RECRUITING

Portland, Oregon, 97210, United States
Hebei Petro China Central Hospital
RECRUITING

Langfang, 065000, China
Hector-Center für Ernährung, Bewegung und Sport, Universitätsklinikum Erlangen;Medizinische Klinik 1 ? Gastroenterologie, Pneumologie und Endokrinologie
RECRUITING

Erlangen, 91054, Germany
Heidelberg Repatriation Hospital
RECRUITING

Heidelberg, Victoria, 3081, Australia
Herz- und Diabeteszentrum NRW Universitätsklinik der Ruhr-Universität Bochum Medizinische Fakultät OWL (Universität Bielefeld);Klinik für Diabetologie und Endokrinologie
RECRUITING

Bad Oeynhausen, 32545, Germany
Higashijujo Sakai Diabetes Internal Medicine Clinic
RECRUITING

Tokyo, 114-0001, Japan
Hometown Urgent Care and Research - Dayton
RECRUITING

Dayton, Ohio, 45424, United States
Hopital Européen Georges Pompidou;Service d?endocrinologie, diabétologie et nutrition
RECRUITING

Paris, 75015, France
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Erasme
RECRUITING

Brussels, 1070, Belgium
Hospital Quironsalud Infanta Luisa
RECRUITING

Seville, 41010, Spain
Hospital Ruber Juan Bravo
RECRUITING

Madrid, 28006, Spain
Hospital San Rafael A Coruna
RECRUITING

A Coruña, LA Coruna, 15006, Spain
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, DUMMY_VALUE, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitário Onofre Lopes - UFRN
RECRUITING

Natal, Rio Grande do Norte, 59012-300, Brazil
Hospital Vithas Sevilla
RECRUITING

Seville, 41950, Spain
Hospital de Base de Sao Jose do Rio Preto
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
Houston Research Institute
RECRUITING

Houston, Texas, 77079, United States
Huizhou Central People's Hospital
RECRUITING

Huizhou, 516001, China
I.R.C.C.S Policlinico San Donato
RECRUITING

San Donato Milanese (MI), Lombardy, 20097, Italy
IMA Clinical Research - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
IME - Instituto Médico Especializado
RECRUITING

Buenos Aires, C1405BCH, Argentina
Indywidualna Specjalistyczna Praktyka Lekarska Krzysztof Cymerman
RECRUITING

Gdynia, 81-157, Poland
InnoDiab Forschung GmbH
RECRUITING

Essen, 45136, Germany
Innovative Clinical Research
RECRUITING

Clarksville, Tennessee, 37040, United States
Instittuto Nacional de Ciencias Medicas y Nutricion "Salvador Subiran"
RECRUITING

México, Mexico CITY (federal District), 14000, Mexico
Instituto Jalisciense de investigacion en diabetes y obesidad S.C.
RECRUITING

Guadalajara, Jalisco, 44650, Mexico
Instituto centenario
RECRUITING

Ciudad Autonoma Buenos Aires, C1204AAD, Argentina
Instituto de Diabetes, Obesidad y Nutricion S.C. Coordinacion
RECRUITING

Cuernavaca, Morelos, 62250, Mexico
International Diabetes Center At Park Nicollet
RECRUITING

Minneapolis, Minnesota, 55416, United States
Isala
RECRUITING

Zwolle, 8025 AB, Netherlands
Jinan Central Hospital
RECRUITING

Jinan, Shandong, 250013, China
Kangbuk Samsung Hospital
RECRUITING

Seoul, 03181, South Korea
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Kasugai Municipal Hospital
RECRUITING

Aichi, 486-8510, Japan
Knownwell
RECRUITING

Schaumburg, Illinois, 60194, United States
Knownwell
RECRUITING

Needham, Massachusetts, 02492, United States
Konyang University Hospital
RECRUITING

Daejeon, 35365, South Korea
Kyungpook National University Hospital
RECRUITING

Daegu, Daegu Gwang'yeogsi, 41944, South Korea
Leicester General Hospital
RECRUITING

Leicester, LE5 4PW, United Kingdom
MED-TIMA Kft.
RECRUITING

Budapest, 1132, Hungary
MEDICON a.s. - Poliklinika Bud?jovická
RECRUITING

Prague, 140 00, Czechia
MUDr. Alena Váchová, Diabetologie
RECRUITING

České Budějovice, 37011, Czechia
MediSpo Clinic
RECRUITING

Prague, 120 00, Czechia
Medical Center Metas SC
RECRUITING

Col Saucito, Chihuahua, 31110, Mexico
Medizentrum Essen Borbeck
RECRUITING

Essen, 45355, Germany
Mesut Durmaz - Facharzt für Innere Medizin, Endokrinologie & Diabetologie
RECRUITING

Hof, 95030, Germany
Monklands Hospital
RECRUITING

Airdrie, ML6 0JS, United Kingdom
Monroe Biomedical Research
RECRUITING

Louisville, Kentucky, 40213, United States
NTT Medical Center Sapporo
RECRUITING

Hokkaido, 060-0061, Japan
NZOZ Specialistyczny Osrodek Internistyczno - Diabetologiczny
RECRUITING

Bialystok, 15-435, Poland
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10048, Taiwan
Nucleo de Pesquisa Clinica do Rio Grande do Sul NPCR
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Osrodek Badan Klinicznych Metabolica
RECRUITING

Tarnów, 33-100, Poland
Paratus Clinical Western Sydney
RECRUITING

Blacktown, New South Wales, 2148, Australia
Peking University People's Hospital
RECRUITING

Beijing, 100044, China
Pingxiang People's Hospital
RECRUITING

Pingxiang, 337000, China
Pinnacle Clinical Research - South San Antonio
RECRUITING

San Antonio, Texas, 78222, United States
Pinnacle Research Group
RECRUITING

Anniston, Alabama, 36207, United States
Polsko-Amerykanskie Kliniki Serca;X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji
RECRUITING

Tychy, 43-100, Poland
Queen Elizabeth University Hospital Glasgow
RECRUITING

Glasgow, G51 4TF, United Kingdom
Radboud Universitair Medisch Centrum
RECRUITING

Nijmegen, 6525 GA, Netherlands
Rochester Clinical Research
RECRUITING

Buffalo, New York, 14217, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
RECRUITING

Union City, Georgia, 30291, United States
Rowden Surgery
RECRUITING

Chippenham, Wiltshire, SN15 2SB, United Kingdom
Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, NSW 2065, Australia
Royal Victoria Infirmary
RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Schwerpunktpraxis für Diabetes und Ernährungsmedizin, Dr. med. Winfried Keuthage
RECRUITING

Münster, 48153, Germany
Semmelweis Egyetem, Varosmajori Sziv- es Ergyogyaszati Klinika
RECRUITING

Budapest, 1122, Hungary
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggido, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Shanghai Pudong New Area People's Hospital
RECRUITING

Shanghai, 201299, China
Singleton Hospital
RECRUITING

Swansea, SA2 8QA, United Kingdom
Soham Staploe Medical Centre
RECRUITING

Soham, Cambridgeshire, CB75JD, United Kingdom
South Texas Clinical Research
RECRUITING

Corpus Christi, Texas, 78404, United States
South Texas Research Institute - Brownsville
RECRUITING

Brownsville, Texas, 78520, United States
Southern Adelaide Diabetes and Endocrine Services (SADES)
RECRUITING

Oaklands Park, South Australia, 5046, Australia
Suburban Research Associates - West Chester Office
RECRUITING

West Chester, Pennsylvania, 19380, United States
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont;Belgyogyaszati Klinika
RECRUITING

Szeged, 6725, Hungary
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance
RECRUITING

Southlake, Texas, 76092, United States
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, DUMMY_VALUE, China
The First Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215333, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Second Affiliated Hospital of Nanjing Medical University
RECRUITING

Nanjing, 210003, China
The Second People's Hospital of Hefei
RECRUITING

Hefei, 230011, China
The University of Osaka Hospital
RECRUITING

Osaka, 565-0871, Japan
Trial Management Associates
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
UZ Leuven Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Unity Healthcare Clinic
RECRUITING

Surrey, British Columbia, V3T 4G8, Canada
Universita Degli Studi Di Perugia
RECRUITING

Perugia, Umbria, 06129, Italy
Universitaets Klinikum Frankfurt - Zentrum der Inneren Medizin
RECRUITING

Frankfurt, 60596, Germany
Universitair Medisch Centrum Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294-3360, United States
University of Texas Southwestern Medical Center - Children's Medical Center Dallas
RECRUITING

Dallas, Texas, 75390, United States
Università Degli Studi di Pisa - Ospedale di Cisanello Pisa
RECRUITING

Pisa, Tuscany, 56124, Italy
Unterfrintroper Hausarztzentrum
RECRUITING

Essen, 45359, Germany
Wharton Medical Clinic
RECRUITING

Hamilton, Ontario, L8L 5G8, Canada
Yale University
RECRUITING

New Haven, Connecticut, 06519, United States
Yan'an University Xianyang Hospital
RECRUITING

Xianyang, Shaanxi, 712000, China
Zentrum für klinische Forschung Köln - Dünnwald;Dünnwald Praxis
RECRUITING

Köln - Dünnwald, 51069, Germany

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