New obesity drug MBX 4291 enters first human safety trial
NCT ID NCT07142707
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study is testing an experimental drug, MBX 4291, in 124 adults with obesity. The main goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo as a shot under the skin, and researchers will monitor for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MBX 4291 (an experimental drug given as a shot under the skin)
What this could lead to
If safe and effective, this could lead to a new weight-loss medication for people with obesity.
What could go wrong
This is a very early Phase 1 trial focused on safety, not weight loss. The drug may not work or could have side effects. Many early-stage drugs never make it to market.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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MBX Biosciences Investigational Site
RECRUITINGDoral, Florida, 33172, United States
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MBX Biosciences Investigational Site
RECRUITINGLexington, Kentucky, 40509, United States
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MBX Biosciences Investigational Site
RECRUITINGKansas City, Missouri, 64114, United States
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MBX Biosciences Investigational Site
RECRUITINGKnoxville, Tennessee, 37920, United States