New obesity drug MBX 4291 enters first human safety trial

NCT ID NCT07142707

Recruiting now Disease control Sponsor: MBX Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study is testing an experimental drug, MBX 4291, in 124 adults with obesity. The main goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo as a shot under the skin, and researchers will monitor for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MBX 4291 (an experimental drug given as a shot under the skin)
What this could lead to: If safe and effective, this could lead to a new weight-loss medication for people with obesity.
What could go wrong: This is a very early Phase 1 trial focused on safety, not weight loss. The drug may not work or could have side effects. Many early-stage drugs never make it to market.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Body Weight nutritional disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

MBX Biosciences Investigational Site
RECRUITING

Doral, Florida, 33172, United States
MBX Biosciences Investigational Site
RECRUITING

Lexington, Kentucky, 40509, United States
MBX Biosciences Investigational Site
RECRUITING

Kansas City, Missouri, 64114, United States
MBX Biosciences Investigational Site
RECRUITING

Knoxville, Tennessee, 37920, United States

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