Scientists probe why junk food is so hard to resist

NCT ID NCT05437809

Recruiting now Knowledge-focused Sponsor: Oregon Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how different types of ultra-processed foods—like those high in fat, sugar, or both—affect feelings of reward and overeating. Fifty adults with obesity will eat various snack foods in the lab and report their cravings and mood. The goal is to understand what makes these foods so tempting, which could help develop new treatments for overeating and obesity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ultra-processed foods (high fat, high refined carbohydrates, or both)
What this could lead to: If successful, this could identify which ingredients in ultra-processed foods drive overeating, leading to better strategies for treating obesity.
What could go wrong: This is an early observational study with only 50 participants, so findings may not apply broadly. It measures short-term responses, not long-term weight loss.

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Conditions

The condition(s) this trial relates to.

Food Addiction Hyperphagia Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOOD ADDICTION OBESITY OVEREATING

Contacts and locations

Locations

Drexel University
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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