Could losing weight on 800 calories a day reshape your bone marrow?

NCT ID NCT07731438

Recruiting now Knowledge-focused Sponsor: General University Hospital, Prague Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This study tests whether an 8-week very-low-calorie diet (600-800 kcal/day) can alter bone marrow fat, bone health, and stem cell function in obese premenopausal women. Researchers will use MRI and biopsies to measure changes in vertebral bone marrow fat and the behavior of bone marrow stem cells. A group of lean women serves as a comparison. The goal is to understand how weight loss affects the bone marrow environment and whether it might improve bone strength.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a very-low-calorie diet (600-800 kcal/day) using Cambridge Weight Plan products
What this could lead to: If successful, this could reveal whether diet-induced weight loss improves bone marrow health and identifies markers of obesity-related bone fragility.
What could go wrong: This is a small, early-stage study in premenopausal women only. Results may not apply to men or other groups, and the diet is very restrictive, which may affect adherence.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

General University Hospital in Prague
RECRUITING

Prague, 12800, Czechia
Institute of Endocrinology, Prague, a state-funded organization established by the Ministry of Health of the Czech Republic.
RECRUITING

Prague, 12800, Czechia
Institute of Physiology of the Czech Academy of Sciences
RECRUITING

Prague, 14200, Czechia

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