Scientists zap brains to unlock secrets of satiety

NCT ID NCT06105164

Recruiting now Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses a noninvasive brain stimulation technique called TMS to investigate how the cerebellum influences feelings of fullness and eating behavior. Researchers will compare brain activity and food choices in 150 healthy adults after they eat or fast. The goal is to better understand the brain circuits involved in appetite control, which could inform future obesity treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Repetitive Transcranial Magnetic Stimulation (rTMS)
What this could lead to: If successful, this could reveal a brain circuit that controls appetite, pointing toward new treatments for obesity.
What could go wrong: This is an early-stage, observational study in healthy people, not a treatment trial. It may not translate into real-world weight-loss solutions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Appetitive Behavior Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APPETITIVE BEHAVIOR OBESITY

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02120, United States
McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States

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