New combo pill aims to boost weight loss and fight inflammation

NCT ID NCT07220629

Ongoing Disease control Sponsor: NodThera Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether adding an experimental anti-inflammatory drug called NT-0796 to the weight-loss medication semaglutide can help people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 to 45 will take either the combination or a placebo for 6 months, along with a reduced-calorie diet and exercise. The main goals are to check safety and see if the combination leads to greater weight loss and lower levels of inflammatory markers like hsCRP.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NT-0796 (an oral anti-inflammatory drug) added to semaglutide (a weight-loss medication)
What this could lead to: If it works, this could lead to a more effective combination treatment for obesity, potentially improving weight loss and reducing inflammation.
What could go wrong: This is an early Phase 2a trial with only 82 participants, so results may not be conclusive. The added drug may cause side effects like nausea or vomiting, and it is unclear if it will provide significant benefit over semaglutide alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Investigative Site

Mesa, Arizona, 85225, United States
Investigative Site

Hialeah, Florida, 33016, United States
Investigative Site

Jacksonville, Florida, 32216, United States
Investigative Site

Miami, Florida, 33147, United States
Investigative Site

Marrero, Louisiana, 70006, United States
Investigative Site

Columbus, Ohio, 43213, United States
Investigative Site

Seabrook, Texas, 77586, United States
Investigative Site

Salt Lake City, Utah, 84124, United States
Investigative Site

Manassas, Virginia, 20110, United States

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