Could a Low-Dose anesthetic lift Post-Surgery depression?

NCT ID NCT07179913

Ongoing Symptom relief Sponsor: The First Hospital of Jilin University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a low dose of esketamine, given during and after weight-loss surgery, can help reduce depression in patients who were already depressed before surgery. Forty adults with a BMI over 35 and a Hamilton Depression score of 7 or higher are taking part. The goal is to see if this approach lowers the number of people with depression after surgery and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Esketamine
What this could lead to: If it works, this could offer a way to ease depression after weight-loss surgery, potentially improving recovery and quality of life.
What could go wrong: This is a small, early-phase trial with only 40 participants, so results may not apply widely. Esketamine can cause side effects like dizziness or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Consciousness Disorders Depression depressive disorder obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARIATRIC SURGERY DEPRESSED

Contacts and locations

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Locations

Zhiwen Li

Changchun, Jilin, 130021, China

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