Weekly shot could help kids lose weight – major trial underway
NCT ID NCT05726227
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This study tests whether a once-weekly injection of semaglutide helps children and teenagers (ages 6 to 17) with obesity or overweight lose weight. About 210 participants will receive either the drug or a placebo for up to 2.5 years, along with healthy lifestyle counseling. The main goal is to see if the drug reduces body mass index (BMI) compared to placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- semaglutide (a once-weekly injection, also used for diabetes and weight loss in adults)
- What this could lead to
- If it works, this could provide a new, effective weight-management option for children and teenagers with obesity.
- What could go wrong
- This is a Phase 3 trial, but results are not yet available. The drug may cause side effects like nausea or vomiting, and weight loss may not be sustained long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aalborg Universitetshospital - Børne og Ungeafdelingen
Gistrup, 9260, Denmark
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Aarhus Universitetshospital, Steno Diabetes Center Aarhus
Aarhus, 8200, Denmark
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Akademiska sjukhuset Uppsala
Uppsala, 75185, Sweden
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Alder Hey Children's Hospital
Liverpool, L12 2AP, United Kingdom
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Barry J. Reiner, MD LLC
Baltimore, Maryland, 21229, United States
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Birmingham Children's Hospital
Birmingham, B4 6NH, United Kingdom
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Centricity Research - Ohio
Columbus, Ohio, 43213, United States
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Clinical Trials of America LLC
Monroe, Louisiana, 71201, United States
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Columbus Research Foundation
Columbus, Georgia, 31904, United States
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Consultorio de Endocrinología y Pediatría
Puebla City, 72190, Mexico
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Drottning Silvias barnsjukhus
Gothenburg, 41650, Sweden
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Eastside Bariatric and Gen Surg
Snellville, Georgia, 30078, United States
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Hallands sjukhus Halmstad
Halmstad, 30233, Sweden
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Hannoversche Kinderheilanstalt "Auf der Bult" - Diabeto-, Endokrino-, Gastroenterologie und Klinische Forschung
Hanover, 30173, Germany
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Health Res of Hampton Roads
Newport News, Virginia, 23606, United States
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Holbæk Sygehus - Børne- og Ungeafdelingen
Holbæk, 4300, Denmark
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Hospital CUF Porto S.A.
Porto, 4100-180, Portugal
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Hospital da Luz Lisboa, S.A.
Lisbon, 1500-650, Portugal
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IMA Clinical Research
Monroe, Louisiana, 71201, United States
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Kinder- und Jugendkrankenhaus
Hanover, 30173, Germany
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Leeds Children's Hospital
Leeds, LS1 3EX, United Kingdom
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Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
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Massachusetts General Hospital_Cary
Boston, Massachusetts, 02114, United States
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Mississippi CTR for ADV MED
Madison, Mississippi, 39110, United States
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Mississippi Center for Advanced Medicine
Madison, Mississippi, 39110, United States
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Neighborhood Healthcare
Escondido, California, 92025, United States
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Pediatric Clinical Trials, LLC
Tullahoma, Tennessee, 37388, United States
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Pennington Biom Res Ctr
Baton Rouge, Louisiana, 70808, United States
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Rambam MC - Department of Pediatrics A
Haifa, 31096, Israel
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Schneider MC - Endrocrinology and Diabetes
Petah Tikva, 49202, Israel
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Shamir MC - Pediatric and Adolescents Endocrinology unit
Ẕerifin, 7033001, Israel
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Solaris Clinical Research
Meridian, Idaho, 83646, United States
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Southampton General Hospital
Southampton, SO16 6YD, United Kingdom
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Texas Diabetes & Endocrinology
Austin, Texas, 78731, United States
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UBMD Peds-Div of Endo/Diabetes
Buffalo, New York, 14203, United States
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ULS De Santo António, E.P.E. - Hospital de Santo António
Porto, 4050-342, Portugal
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UPMC Child Hosp-Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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UZ Antwerpen - UZA - Kinderziekenhuis
Edegem, 2650, Belgium
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UZ Brussel
Brussels, 1090, Belgium
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UZ Leuven - Kindergeneeskunde
Leuven, 3000, Belgium
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UZA - UZ Antwerpen - Kinderziekenhuis
Edegem, 2650, Belgium
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Uniklinik Leipzig - Klinik und Poliklinik für Kinder- und Jugendmedizin
Leipzig, 04103, Germany
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Uniklinik Ulm - Dt. Zentrum für Kinder- und Jugendgesundheit (DZKJ)
Ulm, 89075, Germany
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Univ Of Texas Hlth Science Cntr
San Antonio, Texas, 78207, United States
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University Hospitals Bristol & Weston NHS Foundation Trust
Bristol, BS2 8BJ, United Kingdom
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University of Minnesota
Minneapolis, Minnesota, 55414, United States
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Universitätsklinik Kinder-Jugendheilkunde Innsbruck
Innsbruck, 6020, Austria
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Universitätsklinik für Kinder und Jugendheilkunde Haus E
Salzburg, 5020, Austria
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Universitätsklinikum Halle - Innere Medizin II
Halle, 06120, Germany
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Universitätsklinikum Leipzig, Klinik und Poliklinik für Kinder- und Jugendmedizin
Leipzig, 04103, Germany
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Universitätsklinikum Ulm für Kinder- und Jugendmedizin
Ulm, 89075, Germany
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Uppsala universitetssjukhus
Uppsala, 75185, Sweden
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Valley Weight Loss Clinic
Fargo, North Dakota, 58104, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
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WakeMed Childn Endo-Dbt_Raleig
Raleigh, North Carolina, 27610, United States
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Yale School of Medicine
New Haven, Connecticut, 06519, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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