New procedure aims to keep weight off after GLP-1 drugs are stopped

NCT ID NCT06484114

Ongoing Disease control Sponsor: Fractyl Health Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a procedure called Revita DMR, which uses a thin tube to treat the lining of the upper gut, to help people with obesity keep weight off after they stop taking the weight-loss drug tirzepatide. About 315 participants who lost at least 15% of their body weight on tirzepatide will be randomly assigned to get the real procedure or a sham (fake) procedure. The main goal is to see if the procedure prevents weight regain over six months to a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Revita Duodenal Mucosal Resurfacing (DMR) procedure
What this could lead to: If it works, this could offer a way for people with obesity to keep weight off after stopping GLP-1 drugs like tirzepatide, reducing the need for lifelong medication.
What could go wrong: This is a mid-stage study, so results are not yet proven. The procedure is invasive and may not work for everyone; weight regain is still possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Body Weight Body Weight Changes Body-Weight Trajectory Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY WEIGHT CHANGE TRAJECTORY WEIGHT CHANGE, BODY

Contacts and locations

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Locations

Advent Health

Orlando, Florida, 32804, United States
American Health Network - Franklin

Franklin, Indiana, 46131, United States
American Health Network - Greenfield

Greenfield, Indiana, 46140, United States
American Health Network - Muncie

Muncie, Indiana, 47304, United States
Baylor St. Luke's Medical Center

Houston, Texas, 77030, United States
Cleveland Clinic, Weston

Weston, Florida, 33331, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Encore Borland-Groover Clinical Research

Jacksonville, Florida, 32256, United States
Helios Clinical Research

Phoenix, Arizona, 85028, United States
Hoag Hospital

Newport Beach, California, 92663, United States
Honor Health

Scottsdale, Arizona, 85258, United States
Indiana University

Indianapolis, Indiana, 46202, United States
International Research Associates

Miami, Florida, 33183, United States
Investigators Research Group, LLC

Brownsburg, Indiana, 46112, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
Juno Research, LLC

Houston, Texas, 77040, United States
K2 Medical Research South Orlando

Orlando, Florida, 32806, United States
Metabolic Research Institute

West Palm Beach, Florida, 33401, United States
NYC Research, Inc. (Endocrine Associates of West Village)

Long Island City, New York, 11106, United States
NYU-Langone

New York, New York, 10016, United States
Nature Coast Clinical Research

Inverness, Florida, 32162, United States
Orlando Health Weight Loss and Bariatric Surgery Institute

Orlando, Florida, 32806, United States
Preferred Primary Care Physician

Pittsburgh, Pennsylvania, 15326, United States
Preferred Primary Care Physician

Uniontown, Pennsylvania, 15401, United States
Preferred Primary Care Physician Pittsburgh

Pittsburgh, Pennsylvania, 15243, United States
Simcare Medical Research LLC

Sugar Land, Texas, 77478, United States
Synexus Clinical Research Institute - The Villages (AES)

The Villages, Florida, 32162, United States
UCLA Santa Monica Medical Center

Santa Monica, California, 90095, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Washington, Seattle

Seattle, Washington, 98109, United States
West Virginia University

Morgantown, West Virginia, 26506, United States
Zenith Clinical Research

Hollywood, Florida, 33021, United States

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