New pill could melt fat in people with obesity

NCT ID NCT07169942

Ongoing Disease control Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new oral drug called aleniglipron (GSBR-1290) in 71 adults with obesity (BMI ≥30). Participants take the drug or a placebo daily for 40 weeks. Researchers measure changes in body fat, waist size, and weight using special scans. The goal is to see if the drug safely reduces fat and improves body composition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aleniglipron (GSBR-1290)
What this could lead to: If successful, this could lead to a new oral medication for obesity that reduces body fat and improves body composition.
What could go wrong: This is an early Phase 2 trial with only 71 participants, so results may not apply to everyone. The drug may not work better than placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, OVERWEIGHT, OR CHRONIC WEIGHT MANAGEMENT

Contacts and locations

Locations

Research Site

Phoenix, Arizona, 85020, United States
Research Site

Chicago, Illinois, 60602, United States
Research Site

Richfield, Minnesota, 55423, United States
Research Site

City of Saint Peters, Missouri, 63303, United States
Research Site

Rochester, New York, 14609, United States
Research Site

Wilmington, North Carolina, 28401, United States
Research Site

Norman, Oklahoma, 73069, United States
Research Site

Moncks Corner, South Carolina, 29461, United States
Research Site

North Charleston, South Carolina, 29405, United States
Research Site

Austin, Texas, 78704, United States
Research Site

San Antonio, Texas, 78240, United States

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