Bile acid mystery: does gastric bypass change gut chemistry differently than dieting?
NCT ID NCT03238794
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether losing weight through gastric bypass surgery changes bile acids differently than losing weight through a strict low-calorie diet. Researchers will measure bile acid levels in stool samples from 21 people with obesity. The goal is to understand if the surgery has unique effects on digestion beyond just weight loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Roux-En-Y Gastric Bypass surgery and low-calorie diet
What this could lead to
If successful, this could help explain why gastric bypass surgery may have metabolic benefits beyond just weight loss.
What could go wrong
This is a very small, early study with only 21 participants, so results may not apply to everyone. It is designed to observe differences, not to test a new treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States