Military Weight-Loss drug trial pulled before it began

NCT ID NCT06468748

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to see if the weight-loss drug Wegovy (semaglutide) could help active-duty military personnel lose weight and improve body composition without harming physical performance. It planned to enroll 0 participants and was withdrawn before starting. No results are available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
semaglutide (Wegovy)
What this could lead to
If this trial had succeeded, it could have pointed toward a weight-loss option for military personnel that preserves physical performance.
What could go wrong
The study was withdrawn with zero participants, so no results are available. Even if run, it was small and open-label, limiting reliability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Started

Aug 2024

Finished

Mar 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Active-duty military personnel * Age ≥ 18 years at the time of signing informed consent. * Body mass index (BMI) ≥ 30 kg/m2 or ≥ 27 kg/m2 with the presence of at least one weight-related comorbid condition (e.g., hypertension, dyslipidemia, etc.) * History of at least one self-reported effort to lose body weight. * Ability to exercise ≥ 3x per week during the study. Exclusion Criteria: * Currently in Basic Combat Training, Advanced Individual Training, or One Station Unit Training, or equivalence in other military services. * Current or history of Type 1 or Type 2 Diabetes, cardiovascular (e.g., heart disease, peripheral artery disease), musculoskeletal (e.g., myopathies), immune (e.g., lupus, asthma), gastrointestinal (e.g., irritable bowel syndrome, pancreatitis), neurological (e.g., dystonia), pulmonary (pulmonary fibrosis, COPD, lung cancer), or renal diseases (e.g., kidney diseases), and eating disorders (e.g., bulimia nervosa, anorexia nervosa). * History of cholecystectomy * Personal or family history of medullary thyroid carcinoma or those with multiple endocrine neoplasia type 2. * Participants who are pregnant or breastfeeding, or those who may be pregnant or were pregnant in the last 12 months. * Male and female participants who plan or will attempt to become pregnant or help conceive a child within two months of treatment. * Inability to exercise ≥ 3x per week during the study. * Currently taking or history of routine use of medications known to affect metabolism or performance (e.g., thiazide diuretics, oral steroids, testosterone replacement therapy, etc.). * Self-reported change in body weight ≥ 5 kg within 90 days before screening. * Treatment with any medication for the indication of obesity within 90 days before screening. * Treatment with other orally administered medications such as sulfonylureas, sitagliptin, phenytoin, levothyroxine, albuterol, prednisone, and other drugs as identified during screening by the medical screening and staff. * Current or previously suspected alcohol abuse (defined as Harmful Use by the World Health Organization), those who meet criteria for alcohol abuse disorder (as outlined in the DSM-5), or other substance abuse (i.e., the use of illegal drugs or the use of prescription or over-the-counter drugs for purposes other than those for which they are meant to be used, or in excessive amounts. * History of major depressive disorder. * Participants with implanted or external electrical devices (e.g., pacemakers). * On a specialized diet (e.g., keto, intermittent fasting). * Claustrophobia or difficulty breathing with a face mask. * Known or suspected hypersensitivity to study product(s) or related products.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • USARIEM

    Natick, Massachusetts, 01760, United States

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Other studies related to the condition(s) this trial covers.