Scientists probe epigenetic secrets behind apple and pear body shapes

NCT ID NCT02728635

Ongoing Knowledge-focused Sponsor: AdventHealth Translational Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how genes and fat cells differ in people with apple-shaped (belly fat) versus pear-shaped (hip and thigh fat) bodies. Researchers will use body scans and fat biopsies from 27 healthy adults to compare fat tissue at the molecular level. The goal is to better understand why fat distribution varies, which could lead to improved obesity treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help explain why people store fat in different places, potentially pointing toward new ways to treat obesity-related health issues.
What could go wrong: This is a small, early-stage observational study with only 27 participants, so findings may not apply broadly. It is not testing a treatment, so no direct health benefits are expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Translational Research Institute for Metabolism and Diabetes

Orlando, Florida, 32804, United States

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