Diet breaks may wreck metabolism and gut bugs, study warns

NCT ID NCT06782009

Completed Knowledge-focused Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at what happens to the body when people with obesity stop following restrictive diets like calorie cutting or intermittent fasting. Researchers measured changes in mitochondria (the cell's energy factories) and gut bacteria in 84 adults over 24 weeks. The goal is to understand why weight regain often occurs and how it affects overall health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calorie restriction and intermittent fasting
What this could lead to: If successful, this could help explain why weight regain happens after dieting and point to ways to prevent it.
What could go wrong: This is a small, completed observational study, not a treatment trial. Results may not apply to everyone and do not test a new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Intermittent Fasting Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Departamento de Fisiología de la Nutrición. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Mexico City, 14080, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Mexico City, Tlalpan, 14080, Mexico

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