Can a Two-Drug combo curb Binge-Eating and help weight loss?
NCT ID NCT03946111
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a combination of naltrexone and bupropion can reduce binge-eating episodes and promote weight loss in people with binge-eating disorder and obesity. Participants took either the drug combo or a placebo for 12 weeks. The trial was very small, with only 3 people enrolled, so results are preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- naltrexone and bupropion combination
- What this could lead to
- If it works, this could offer a medication option to reduce binge-eating episodes and support weight loss in people with obesity.
- What could go wrong
- This is a very small, early-phase study with only 3 participants, so results may not apply broadly. The drug combo may cause side effects like nausea or insomnia.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Yale Department of Psychiatry
New Haven, Connecticut, 06510, United States
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