New daily pill shows promise for weight loss in obesity trial
NCT ID NCT06867718
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 study tested a once-daily pill called RGT001-075 in 267 adults who are obese or overweight with weight-related health problems like high blood pressure or sleep apnea. The goal was to see if the drug helps with weight loss and is safe. Participants took either the drug or a placebo for 36 weeks, and researchers measured changes in body weight and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RGT001-075 (a GLP-1 agonist drug taken once daily)
What this could lead to
If successful, this could lead to a new once-daily pill for weight loss in people with obesity or overweight who also have related health issues like high blood pressure or sleep apnea.
What could go wrong
This is an early Phase 2 study with only 267 participants, so results may not apply to everyone. The drug may cause side effects or fail to show meaningful weight loss compared to placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alliance for Multispecialty Research, LLC
Mobile, Alabama, 36608, United States
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Alliance for Multispecialty Research, LLC
Lexington, Kentucky, 40509, United States
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Alliance for Multispecialty Research, LLC
Norman, Oklahoma, 73069, United States
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Angels Clinical Research
Doral, Florida, 33122, United States
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Angels Clinical Research
Miami, Florida, 33126, United States
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Javara-Privia Medical Group Gulf Coast PLLC
The Woodlands, Texas, 77384, United States
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Javara-Privia Medical Group, Georgia LLC
Savannah, Georgia, 31406, United States
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Javara-Privia Medical Group, Georgia, LLC
Thomasville, Georgia, 31792, United States
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Javara-Tryon Medical Partners, PLLC
Charlotte, North Carolina, 28287, United States
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Mankato Clinic-East Main Street-Javara
Mankato, Minnesota, 56001, United States
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Optimal Research
Melbourne, Florida, 32934, United States
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Palm Springs Community Health Center
Miami Lakes, Florida, 33014, United States
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Premier Health Research-Sparta-Objective Health
Sparta, New Jersey, 07871, United States
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Synexus Clinical Research
Phoenix, Arizona, 85020, United States
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Synexus Clinical Research
The Villages, Florida, 32162, United States
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Synexus Clinical Research
Evansville, Indiana, 47714, United States
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Synexus Clinical Research
Richfield, Minnesota, 55423, United States
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Synexus Clinical Research
Creve Coeur, Missouri, 63141, United States
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Synexus Clinical Research
Dallas, Texas, 75234, United States
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Synexus Clinical Research
San Antonio, Texas, 78229, United States
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Synexus Clinical Research
Salt Lake City, Utah, 84106, United States
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Velocity Clinical Research
Huntington Park, California, 90255, United States
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Velocity Clinical Research
Valparaiso, Indiana, 46383, United States
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Velocity Clinical Research
Baton Rouge, Louisiana, 70809, United States
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Velocity Clinical Research
Rockville, Maryland, 20854, United States
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Velocity Clinical Research
Omaha, Nebraska, 68134, United States
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Velocity Clinical Research
Vestal, New York, 13850, United States
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Velocity Clinical Research
Durham, North Carolina, 27701, United States
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Velocity Clinical Research
Cincinnati, Ohio, 45246, United States
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Velocity Clinical Research
Cleveland, Ohio, 44122, United States
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Velocity Clinical Research
East Greenwich, Rhode Island, 02818, United States
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Velocity Clinical Research
Dallas, Texas, 75230, United States
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Velocity Clinical Research
Waco, Texas, 76710, United States
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Velocity Clinical Research
West Jordan, Utah, 84088, United States
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Velocity Clinical Research
Seattle, Washington, 98105, United States