New oral weight loss pill shows promise in Mid-Stage trial

NCT ID NCT06579092

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a new daily pill called AZD5004 for weight loss in 310 adults with obesity or overweight who also had a weight-related health problem like high blood pressure. Participants took either the drug or a placebo for 36 weeks. The main goal was to see if the drug helped people lose more weight than the placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD5004 (oral tablet)
What this could lead to: If successful, this could lead to a new daily pill for weight loss in people with obesity or weight-related health issues.
What could go wrong: This is a Phase II trial, so it's still early. The drug may not work better than placebo, or side effects could limit its use. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OR OVERWEIGHT

Contacts and locations

Locations

Research Site

Chandler, Arizona, 85225, United States
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Huntington Park, California, 90255, United States
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La Mesa, California, 91942, United States
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Lincoln, California, 95648, United States
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Walnut Creek, California, 94598, United States
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Hialeah, Florida, 33012, United States
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Orlando, Florida, 32806, United States
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Lombard, Illinois, 60148, United States
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Valparaiso, Indiana, 46383, United States
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West Des Moines, Iowa, 50266, United States
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Roslindale, Massachusetts, 02131, United States
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Farmington Hills, Michigan, 48334, United States
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Chesterfield, Missouri, 63005, United States
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Omaha, Nebraska, 68134, United States
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Vestal, New York, 13850, United States
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Durham, North Carolina, 27701, United States
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Wilmington, North Carolina, 28401, United States
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Fargo, North Dakota, 58104, United States
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Beachwood, Ohio, 44122, United States
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Cincinnati, Ohio, 45219, United States
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North Charleston, South Carolina, 29405, United States
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Spartanburg, South Carolina, 29303, United States
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Knoxville, Tennessee, 37912, United States
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Austin, Texas, 78735, United States
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Dallas, Texas, 75230, United States
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Houston, Texas, 77040, United States
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Woodway, Texas, 76712, United States
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Ogden, Utah, 84405, United States
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Charlottesville, Virginia, 22911, United States
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Manassas, Virginia, 20110, United States
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Heidelberg, 3081, Australia
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Merewether, 2291, Australia
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St Albans, 3021, Australia
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St Leonards, 2065, Australia
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Calgary, Alberta, T2V 4J2, Canada
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Surrey, British Columbia, V3T 2V6, Canada
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Victoria, British Columbia, V8V 4A1, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Guelph, Ontario, N1G 0B4, Canada
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Hamilton, Ontario, L8J 0B6, Canada
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Hamilton, Ontario, L8L 5G8, Canada
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Toronto, Ontario, M9V 4B4, Canada
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Toronto, Ontario, M9W 4L6, Canada
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Terrebonne, Quebec, J6X 4P7, Canada
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Bad Oeynhausen, 32545, Germany
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Berlin, 10787, Germany
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Hamburg, 22607, Germany
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Mannheim, 68167, Germany
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Münster, 48145, Germany
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Oldenburg, 23758, Germany
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Sankt Ingbert, 66386, Germany
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Suita-shi, 565-0853, Japan
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Kaohsiung City, 807, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10048, Taiwan
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Blackpool, FY3 7EN, United Kingdom
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Bristol, BS34 6BQ, United Kingdom
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Chesterfield, S40 4AA, United Kingdom
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Leicester, Le5 4PW, United Kingdom
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Rotherham, S65 1DA, United Kingdom
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Witney, OX28 6JS, United Kingdom

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