Can krill oil boost Metformin's benefits for PCOS? small trial hints at possibility

NCT ID NCT07604870

Completed Disease control Sponsor: Firat University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether adding krill oil to standard metformin therapy improves metabolic health in women with PCOS and obesity. Fifty-four women were split into three groups: metformin alone, krill oil alone, or both together for 8 weeks. Researchers measured changes in blood markers like adiponectin and insulin resistance to see if the combination offers extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Krill oil and metformin
What this could lead to: If it works, this could point toward a simple supplement-plus-medication approach to improve metabolic health in women with PCOS and obesity.
What could go wrong: This is a small pilot trial with only 54 participants and no placebo group, so results are preliminary and may not apply to everyone. Krill oil is a supplement, not a proven treatment for PCOS.

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Conditions

The condition(s) this trial relates to.

metabolic syndrome X Obesity obesity disorder polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, METABOLIC POLYCYSTIC OVARY SYNDROME

Contacts and locations

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Locations

Firat University, Faculty of Health Sciences, Department of Nutrition and Dietetics

Elâzığ, 23119, Turkey (Türkiye)

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