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Can krill oil boost Metformin's benefits for PCOS? small trial hints at possibility

NCT ID NCT07604870

Disease control Sponsor: Firat University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether adding krill oil to standard metformin therapy improves metabolic health in women with PCOS and obesity. Fifty-four women were split into three groups: metformin alone, krill oil alone, or both together for 8 weeks. Researchers measured changes in blood markers like adiponectin and insulin resistance to see if the combination offers extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Krill oil and metformin
What this could lead to
If it works, this could point toward a simple supplement-plus-medication approach to improve metabolic health in women with PCOS and obesity.
What could go wrong
This is a small pilot trial with only 54 participants and no placebo group, so results are preliminary and may not apply to everyone. Krill oil is a supplement, not a proven treatment for PCOS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

54 people

The number who actually took part.

Started

Mar 2023

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female sex, aged 19-40 years 2. Diagnosis of Polycystic Ovary Syndrome (PCOS) according to Rotterdam criteria (at least 2 of 3: oligo/anovulation, clinical/biochemical hyperandrogenism, polycystic ovaries on ultrasound) 3. Metabolically Unhealthy Obesity (MUO) defined by combined NCEP ATP-III/IDF criteria (waist circumference \>88 cm plus ≥2 metabolic risk factors) 4. BMI ≥ 30 kg/m2 5. Willingness to provide written informed consent Exclusion Criteria: 1. Type 1 or Type 2 diabetes mellitus 2. Thyroid disorders (uncontrolled hypo- or hyperthyroidism) 3. Renal or hepatic disease 4. Cardiovascular disease 5. Use of oral contraceptives, insulin sensitizers, lipid-lowering drugs, or omega-3 supplements in the past 3 months 6. Pregnancy or lactation 7. Allergy to fish or seafood (krill oil contraindication) 8. Participation in another clinical trial 9. Smokers or alcohol users

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Conditions

The condition(s) this trial relates to.

metabolic syndrome X Obesity obesity disorder polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity, metabolic Polycystic ovary syndrome

Contacts and locations

Locations

  • Firat University, Faculty of Health Sciences, Department of Nutrition and Dietetics

    Elâzığ, 23119, Turkey (Türkiye)

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