Gut-Brain boost: psychobiotic plus diet shows promise for obese women

NCT ID NCT06861049

Completed Disease control Sponsor: Medipol University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a daily psychobiotic supplement (a mix of friendly bacteria) plus a weight-loss diet could improve mental health, quality of life, and body measurements in 28 obese women over 4 weeks. Participants were randomly assigned to receive either the supplement or a placebo, and researchers tracked changes in weight, BMI, mood, and inflammation markers. The goal is to see if targeting the gut-brain connection can help both mental health and obesity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Psychobiotic supplement (Lactobacillus helveticus R0052, Bifidobacterium bifidum R0071, Bifidobacterium longum R0175)
What this could lead to: If it works, this could point toward a simple supplement to boost mental health and weight loss in obese women.
What could go wrong: This is a very small, short-term study (28 women, 4 weeks). Results may not apply to everyone, and the effect may be small or not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENTAL HEALTH OBESITY PROBIOTIC

Contacts and locations

Locations

Istanbul Medipol University

Istanbul, Turkey (Türkiye)

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