University Of California, Irvine

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…

This study tested a personalized education program called 'Mi Propio Camino' (My Own Way) to help Hispanic adults with uncontrolled high blood pressure stick to their medication. Over 500 participants received either the tailored program or standard care. The goal was to see if p…

This study tested a brain-computer interface (BCI) combined with functional electrical stimulation (FES) to help stroke survivors with foot weakness walk better. 62 adults who had a stroke at least 6 months prior and had trouble walking participated. The therapy used brain signal…

This study tested whether a 5-day decolonization routine using nasal ointment, mouth rinse, and body wash could prevent MRSA infections in over 2,000 adults carrying the bacteria after hospital discharge. Participants were randomly assigned to either the decolonization regimen or…

This pilot study tested whether a 5-day fasting-mimicking diet (FMD) is feasible and can lower blood sugar in 30 Asian Americans with prediabetes. Participants ate a special plant-based meal kit for five days, then had their blood sugar and physical measurements checked. The goal…

This early-phase trial tested adding the cholesterol drug pitavastatin to the standard leukemia medicine venetoclax in 6 people with chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML). The main goal was to find a safe dose and check for side effects. Researchers a…

This study looked at whether drinking diet beverages (like diet soda) instead of water affects blood sugar control in adults with type 2 diabetes. 181 participants who regularly drank diet beverages were randomly assigned to keep drinking them or switch to plain water for 24 week…

This study tested a non-invasive optical device that uses different types of light to detect and diagnose various mouth conditions, including oral cancer, gum disease, and dry mouth. Over 1,000 participants with and without oral lesions were imaged, and the results were compared …

This study tested two ways to improve dental care for children with autism. One group received a dental toolkit with tips and resources. The other group got the toolkit plus special parent training to help with brushing and dentist visits. The goal was to see if the extra trainin…

This pilot study tested a 6-session therapy called Goal-Focused Emotion Regulation Therapy (GET) in 35 young Latino testicular cancer survivors aged 18-39. The therapy helps participants set goals, manage emotions, and find meaning after cancer. Researchers measured anxiety, depr…

This study tested whether using virtual reality (VR) during a knee pain procedure called genicular nerve radiofrequency ablation could reduce pain and improve satisfaction. Forty adults used a VR headset during the procedure and rated their pain and satisfaction. The goal was to …

This pilot study tested a culturally tailored mindfulness program for 18 low-income, Spanish-speaking Latina pregnant women. The goal was to see if the program could reduce stress and improve markers of inflammation and blood sugar control. Participants were split into two groups…

This study tested a personalized internet-based program (WebTIPS) to help children ages 1-12 feel less anxious before surgery and recover more smoothly. Over 1,200 parent-child pairs took part, with some using the tailored program and others receiving standard online information.…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This study tested whether a drug called dexmedetomidine can help control pain and reduce the need for strong painkillers (opioids) in people with three or more broken ribs from blunt chest injuries. 41 adults in the ICU took part. The goal was to see if the drug could lower pain …

This study tested two ways to do extra arm exercises after a stroke: a custom program designed by a therapist, or using a special movable wheelchair armrest (called Boost). 35 people in acute rehab took part. The goal was to see which method better improves arm movement and reduc…

This study tested whether giving Botox in one injection site works as well as ten sites for women with overactive bladder or urge incontinence. 116 women were randomly assigned to receive 100 units of Botox in either one or ten spots in the bladder. Researchers measured symptom s…

This study tested whether giving tadalafil (Cialis) and/or tamsulosin (Flomax) before kidney stone surgery helps doctors place a larger tube into the ureter, which can make the procedure safer and more effective. 220 adults undergoing surgery for kidney stones were randomly assig…

This study tested a mobile app called Pain Buddy in 206 children aged 8-18 receiving outpatient chemotherapy for cancer. The app lets kids and parents record daily pain, symptoms, and quality of life using a personalized avatar. The goal is to help doctors and nurses monitor symp…

This study tested a culturally relevant program to help Spanish-speaking Latino caregivers of children with cancer feel less stressed and improve their quality of life. 33 caregivers took part, and the program focused on reducing anxiety and depression. The goal was to see if thi…

This study tested whether adding a therapy dog to standard social skills training could help children with ADHD. Thirty-nine children took part, some receiving dog-assisted sessions and others only social skills training. Researchers measured ADHD symptoms, self-esteem, and stres…

This study looked at whether watching short science videos can change how adults with anxiety think about psychological therapy. 262 participants watched 30 minutes of educational videos and filled out surveys about their beliefs and expectations. The goal was to understand if sc…

This study tested whether giving Hispanic/Latinx patients educational materials, financial navigation help, and reminders could increase lung cancer screening with low-dose CT scans. 60 eligible adults aged 50-80 with a smoking history took part. The goal was to see if these simp…

This study looked at how healthy children and young adults (ages 7-35) respond to different types of exercise on a bike or treadmill. Researchers measured oxygen use and heart rate to better understand heart and lung health. The goal is to improve fitness tests and create persona…

This study looked at how stress influences eating and physical activity in African-American, Hispanic, and white teen girls aged 13-17. Researchers measured food intake after stress and non-stress sessions, along with BMI and activity levels. The goal was to understand why obesit…

This study tested a program to help more people at high risk for lung cancer get a low-dose CT scan, which can catch the disease early and save lives. The program included notifying doctors, educating patients, offering financial help, and reminding patients to talk about screeni…

This study tested whether a 6-week, technology-based family program called PAAS could change brain activity linked to risky behavior in African-American teens. 146 teens and their parents participated, with brain scans and questionnaires before and after the program. The goal was…