University Of California, Irvine

This study tested whether giving MRSA carriers a special body wash and nasal ointment (decolonization) after leaving the hospital could prevent future MRSA infections compared to standard education. Over 2,100 adults with a recent MRSA-positive test took part. The goal was to see…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with metastatic colorectal cancer that had stopped responding to standard treatments. The main goal was to find the safest dose and check for side effects. The study is complete and h…

This study tested two educational programs to help Hispanic adults with uncontrolled high blood pressure take their medication as prescribed. Over 500 participants were followed for 6 months to see which approach worked better. The goal was to improve medication adherence and ult…

This study looked at whether drinking artificially sweetened diet beverages affects blood sugar control in adults with type 2 diabetes. 181 participants who already drank diet drinks were randomly assigned to continue drinking them or switch to plain water for 24 weeks. The main …

This early-phase study tested adding the cholesterol-lowering drug pitavastatin to the standard targeted therapy venetoclax for people with chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML). The main goal was to find a safe dose and check for side effects. Only 6…

This study tested a non-invasive optical device that uses light to detect and diagnose various mouth conditions, including gum disease, dry mouth, and oral cancer. Over 1,000 adults with and without oral lesions were imaged using techniques like fluorescence and spectroscopy. The…

This study tested whether using virtual reality (VR) during a knee pain treatment called genicular nerve radiofrequency ablation could help reduce pain and improve patient satisfaction. Forty adults who were already scheduled for the procedure took part. The goal was to see if VR…

This study tested a mobile app called Pain Buddy to help children with cancer track their pain, symptoms, and quality of life while receiving chemotherapy at home. Over 200 kids aged 8-18 used the app daily to report how they felt. The goal was to give doctors and parents better …

This study tested whether giving Botox in one spot inside the bladder works as well as the usual ten injections for women with overactive bladder or urge incontinence. 116 women were randomly assigned to receive either one or ten injections of 100 units of Botox. The main goal wa…

This study tested a personalized internet program called WebTIPS to help children ages 1-12 feel less anxious before and after surgery. Over 1,200 families participated, with some receiving the tailored program and others receiving standard online information. The goal was to see…

This study tested whether a medicine called dexmedetomidine can help control pain in people with three or more broken ribs. The goal was to lower pain scores and reduce the need for strong opioid painkillers. The trial included 41 adults in the ICU after a blunt chest injury.

This study tested a new therapy that uses a brain-computer interface combined with electrical stimulation to help stroke survivors improve their walking. 62 adults who had a stroke at least 6 months earlier and had trouble walking took part. The approach aimed to retrain the brai…

This study tested whether two combinations of migraine medications can reduce the severity of tinnitus (ringing in the ears) in 78 adults with moderate to severe symptoms. Participants took the drugs or a placebo for 8 weeks, and researchers measured changes in tinnitus impact us…

This study looked at whether adding extra arm exercises to standard rehab helps stroke survivors recover arm movement. 35 adults who had a stroke within the past month took part. One group followed a custom exercise program, while the other used a movable wheelchair armrest to mo…

This study tested a culturally relevant program to reduce stress and improve quality of life for Spanish-speaking Latino caregivers of children with cancer. 33 caregivers participated, and the program focused on providing support tailored to their needs. The goal was to see if th…

This pilot study tested whether adding therapy dogs to standard social skills training could help children with ADHD. 39 children participated, comparing dog-assisted sessions to training alone. Researchers measured ADHD symptoms, self-esteem, and social skills, and also looked a…

This study tested whether taking tadalafil (Cialis) or tamsulosin (Flomax) before kidney stone surgery helps doctors place a larger tube into the ureter. A larger tube can make stone removal easier and safer. 220 adults having kidney stone surgery were randomly assigned to receiv…

This study tested a program to help Hispanic/Latinx patients get screened for lung cancer. 60 eligible adults received either extra support (education, reminders, and financial help) or usual care. The goal was to see if the program increased the number of people who got a low-do…

This study looked at whether watching short science videos can change beliefs about psychological therapy in adults with anxiety. 262 participants watched 30 minutes of educational videos and filled out surveys about their confidence in therapy and how helpful they thought it wou…

This pilot study looked at whether a 5-day fasting-mimicking diet (FMD) is practical for Asian Americans with prediabetes. Thirty participants followed the special low-calorie meal plan and had their blood sugar and physical measurements checked before and after. The main goal wa…

This study looked at how stress and race influence eating and physical activity in 258 teen girls from African-American, Hispanic, and Caucasian backgrounds. Participants attended lab sessions where they were either stressed or not, then offered a buffet to measure food choices. …

This study tested a program to help more people get screened for lung cancer. The program included reminders for doctors, education for patients, help with costs, and prompts to talk about screening during visits. The goal was to see if these steps would increase the number of pe…

This study tested whether a 6-week program could change brain activity linked to risky behavior in 146 African-American teens. Researchers used MRI scans and surveys to measure emotional and cognitive control before and after the program. The goal was to understand how the progra…

This study looked at how healthy people aged 7 to 35 respond to different types of exercise, like biking and treadmill walking. Researchers measured oxygen use and heart rate to understand how the body works during activity. The goal is to create better fitness tests and personal…