University Of California, Irvine

This study aims to understand how well women stick to different vaginal estrogen treatments (cream, tablets, or ring) to prevent recurrent urinary tract infections after menopause. Researchers will also examine changes in vaginal tissue and bacteria before and after treatment. Th…

This study is testing whether combining two drugs, CPX-351 and glasdegib, is safe and effective for adults with specific types of acute myeloid leukemia (AML) who have not yet received treatment. The main goal is to see how many patients are still in remission and event-free six …

This study is testing if giving caffeine to very premature babies for a few extra weeks helps them learn to feed by mouth faster. It involves 80 infants who are already stable enough to stop caffeine. Researchers will compare how quickly babies in two groups reach full feeding an…

This study is testing whether a private, peer-led Facebook group can encourage more people with opioid addiction to ask for and start medication treatment. About 640 adults with moderate-to-severe opioid use disorder who are not currently on medication will be randomly placed int…

This early-stage study is testing a new type of cell therapy for people with advanced non-small cell lung cancer that has spread and no longer responds to standard immunotherapy. Researchers are giving patients specially modified immune cells (called NK cells) taken from umbilica…

This small, early-stage study is testing whether it is safe and practical to combine a type of immunotherapy drug (pembrolizumab) with very precise, high-dose radiation (SBRT) for patients with advanced soft-tissue sarcoma. The goal is to see if this combination can help control …

This trial is testing a two-step treatment for stomach or gastroesophageal cancer that has spread to the abdominal lining. First, patients receive standard chemotherapy. If the cancer hasn't spread to other organs, they then receive a second type of chemotherapy delivered directl…

This study aims to develop better, non-invasive ways to detect and understand oral diseases using light-based imaging. Researchers will scan the mouths of 2,500 people with various conditions (like gum disease, sores, or cancer) and healthy volunteers. They will compare these new…

This study is testing a community-based program to help prevent high blood pressure and heart disease in Latino and Vietnamese families in Santa Ana, California. For three years, some families will work with community health workers who provide personalized coaching, educational …

This study tests a program designed to help more Hispanic patients get screened for lung cancer. It works by reminding doctors, educating patients, helping with costs, and prompting discussions during doctor visits. The goal is to see if this approach gets more eligible patients …

This small pilot study is testing whether electroacupuncture—a form of acupuncture with mild electrical stimulation—is a practical and helpful way to manage difficult symptoms after a major abdominal cancer surgery. The study will enroll 20 patients who have undergone this specif…

This study is testing whether a form of acupuncture with mild electrical stimulation can help manage common symptoms in people with cancer or cancer survivors. 70 participants will receive either real or 'sham' electroacupuncture over 10 weeks to see if it eases fatigue, memory p…

This study is testing whether listening to relaxation music can help reduce chronic pain for people with irritable bowel syndrome (IBS), Crohn's disease, or colitis. It involves 120 adults in the US who have had significant gut-related pain for at least three months and also expe…

This study tests different ways to help cancer patients struggling with the high costs of care and basic needs like food and housing. It compares three approaches: one-on-one financial counseling, providing self-help resource lists, and standard care. The goal is to see which met…

This study is exploring whether listening to jazz music, sometimes combined with mindful listening techniques, can help reduce pain for people with chronic pain conditions. About 90 adults with chronic pain will be assigned to either listen to jazz daily for four weeks, listen mi…

This study is testing if the medication mirtazapine can help newly diagnosed brain cancer patients who are feeling depressed and suffering from severe nausea and vomiting caused by their chemotherapy. Researchers will give the drug to about 36 depressed patients for eight weeks t…

This study is testing whether two different combinations of existing migraine medications can help people with recent-onset ringing in the ears (tinnitus). One hundred adults will take either nortriptyline with topiramate or verapamil with paroxetine for eight weeks to see if it …

This study aimed to compare two lidocaine treatments for muscle pain in the neck or back. Emergency room patients would have received either a lidocaine injection directly into the painful muscle knot or worn a lidocaine patch on the skin. The goal was to see which method provide…

This study is testing a Spanish-language digital therapy app called SilverCloud to help Latino patients manage symptoms of depression and anxiety. About 426 participants will try either a self-guided version or one with extra support. Researchers also want to see if finding patie…

This study is testing if adding a new FDA-approved, non-opioid pain pill called suzetrigine to standard pain care works better for adults with multiple broken ribs. Researchers want to see if it improves pain control and helps patients use fewer opioid painkillers, which can be a…

This study is testing whether starting pelvic floor physical therapy before prostate surgery helps men regain bladder control faster. Researchers are comparing men who start therapy before surgery to those who start after, which is current practice. The goal is to see if this sim…

This study is testing a support program for teens and young adults (ages 12-25) who are at high risk for developing psychosis and have had recent suicidal thoughts. The program involves training nominated family members or friends to provide better support, aiming to reduce feeli…

This study aims to understand how a specific antibody in the blood relates to the progression of sporadic inclusion body myositis (sIBM), a rare, progressive muscle disease. Over two years, 150 adults with sIBM will be observed every six months to track changes in their strength,…

This study investigates whether watching educational science videos can influence people's beliefs about psychological therapy for anxiety. Researchers are testing two different types of educational content with 300 adults who experience anxiety. Participants watch videos for 30 …

This study aims to understand if emphasizing certain words in the instructions for mental health questionnaires changes how people answer them. It involves 200 U.S. adults who have been treated for depression or anxiety in the past year. Participants will complete the same questi…