University Of California, Irvine

This study looks at how well women with low estrogen (like after menopause) stick to using vaginal estrogen treatments to prevent repeat urinary tract infections. About 111 women will be randomly assigned to use a cream, tablet, or ring. Researchers will track adherence over 6 mo…

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This phase 2 trial is testing a combination of two drugs—CPX-351 (a chemotherapy) and glasdegib (a targeted pill)—in 30 people with acute myeloid leukemia (AML) that is either linked to a prior blood disorder or caused by previous cancer treatment. The main goal is to see how man…

This phase II trial tests a combination of chemotherapy drugs for stomach cancer that has spread to the lining of the abdomen. About 40 adults will receive standard intravenous chemo plus paclitaxel infused directly into the abdomen. The goal is to see if this approach improves h…

This early-phase trial tests a new treatment for people with advanced non-small cell lung cancer that has stopped responding to standard immunotherapy. The treatment uses immune cells from umbilical cord blood that are genetically modified to better recognize and attack cancer ce…

This pilot study tests whether combining the immunotherapy drug pembrolizumab with stereotactic ablative radiotherapy (SBRT) is feasible for people with advanced or metastatic soft-tissue sarcoma. Nine participants with disease that cannot be surgically removed will receive both …

This study tests whether a culturally tailored, skills-based program delivered by community health workers can help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 participants will receive either the special …

This study tests whether a financial navigation and counseling program (CostCOM) can help newly diagnosed cancer patients who are struggling with costs or basic needs like food and housing. About 91 patients will either get the program, educational materials, or usual care. The g…

This study tests a digital cognitive behavioral therapy program (SilverCloud) for Spanish-speaking adults with depression or anxiety. 426 participants will either use the program on their own or get extra support from a peer coach via phone or messaging. The goal is to see if add…

This study looks at whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help manage pain, nausea, diarrhea, and insomnia in people who have had cytoreductive surgery and heated chemotherapy for cancer. The trial will enroll 20 patients to see if the…

This study aimed to see if a lidocaine injection or a lidocaine patch works better for muscle pain in the neck and back. It was designed for adults visiting the emergency department. However, the study was withdrawn before any participants were enrolled.

This study tests whether daily listening to jazz music combined with mindfulness can reduce chronic pain and anxiety. About 90 adults with chronic pain and moderate-to-severe anxiety will listen to jazz recordings daily for 4 weeks. Researchers will measure changes in pain intens…

This study tests whether listening to jazz or reggae music can reduce chronic pain in people with IBS, Crohn's disease, or colitis. Researchers will compare two groups: one listens to mindful jazz, the other to reggae, over four weeks. The goal is to find a safe, non-addictive wa…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help cancer patients and survivors with clusters of symptoms like memory problems, fatigue, insomnia, anxiety, and depression. Seventy participants will receive either real electro…

This study tests whether adding suzetrigine to standard pain treatments helps adults with multiple broken ribs feel less pain and use fewer opioids. About 80 people will be randomly assigned to get either suzetrigine or a placebo alongside usual care. The goal is to improve breat…

This study looks at whether starting pelvic floor physical therapy before prostate surgery (HoLEP) helps men regain bladder control more quickly after the procedure. About 72 men who are already scheduled for HoLEP to treat an enlarged prostate will be randomly assigned to start …

This study tests whether giving caffeine to preterm infants for a longer period helps them learn to feed by mouth sooner. About 80 babies born at 32 weeks or earlier will be enrolled. Researchers will compare time to full oral feeding and hospital discharge between those who cont…

This study tests whether common migraine medications can reduce the impact of sudden tinnitus (ringing in the ears) in 100 adults aged 25 to 85. Participants receive the drugs and complete questionnaires about their symptoms, plus brain scans to look for changes. The goal is to f…

This phase 2 pilot study is testing whether mirtazapine, an antidepressant, can help with depression, nausea, vomiting, and weight loss in people with high-grade glioma who are starting temozolomide chemotherapy. The study enrolled 120 adults with newly diagnosed glioma. Research…

This study is testing whether giving low-income families extra cash each month helps children's language, thinking, and brain development. One thousand mothers of newborns below the poverty line receive either $333 or $20 per month for over six years. Researchers then compare the…

This study follows 150 adults with sporadic inclusion body myositis (sIBM) for two years to see how the disease progresses. Participants visit the clinic every six months for tests like muscle strength, breathing, and swallowing. No treatments are given—the goal is to learn more …

This study adapts a program called Youth-Nominated Support Team (YST) for suicidal adolescents who are at high risk for psychosis. The goal is to see if having a personally chosen support team helps these teens feel more connected, hopeful, and engaged in treatment. About 70 part…

This study tests whether an online support program called HOPE can help people with opioid use disorder ask for medication treatment. Researchers will assign 640 participants to either the HOPE online community or a control group and track how many request information about medic…

This study explores whether highlighting certain words in questionnaire instructions (like 'bothered by') affects how people with depression or anxiety respond. Two hundred U.S. adults who have been treated for these conditions in the past year will take the same survey twice in …