Which vaginal estrogen works best for recurrent UTIs? new study aims to find out

NCT ID NCT06353269

Ongoing Disease control Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how well women with low estrogen (like after menopause) stick to using vaginal estrogen treatments to prevent repeat urinary tract infections. About 111 women will be randomly assigned to use a cream, tablet, or ring. Researchers will track adherence over 6 months and also examine changes in vaginal tissue and natural bacteria.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vaginal estrogen (estradiol ring, tablet, or cream)
What this could lead to: If successful, this could show which vaginal estrogen form women are most likely to use consistently, potentially reducing recurrent UTIs.
What could go wrong: This is a small, single-site study focused on adherence, not on proving that one treatment works better than another. Results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

urinary tract infection urinary tract infections, recurrent, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOESTROGENISM RECURRENT URINARY TRACT INFECTION

Contacts and locations

Locations

University of California Irvine Medical Center

Orange, California, 92868, United States

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