University Of California, Irvine

This study is testing a new smartphone app designed to help people with cancer take their oral medication correctly. The app tracks pill-taking, monitors symptoms, and connects patients with support for side effects and costs. Researchers are enrolling 35 English- or Spanish-spea…

This study is testing whether adding a low-dose chemotherapy drug (cyclophosphamide) to an existing immunotherapy (pembrolizumab) can help patients with advanced melanoma that has stopped responding to standard treatments. The trial will enroll 14 adults with stage III or IV mela…

This study is testing whether two weight loss medications, alone or combined, can help people who have started to regain weight after bariatric surgery. About 120 adults who had surgery at least 18 months ago and regained at least 5% of their lost weight will receive either the m…

This study is testing whether combining three existing cancer drugs works better to control advanced breast cancer that has spread. It's for people whose cancer is fueled by hormones and has either just been diagnosed as advanced or returned after more than a year. The main goal …

This study is testing if Nelfinavir, a drug originally used for HIV, can help treat anemia in people with myelofibrosis, a rare bone marrow cancer. Researchers want to see if the drug helps restore iron to the bone marrow to improve red blood cell counts and reduce scarring. The …

This study is testing if using a fluorescent green dye during robotic prostate cancer surgery helps surgeons better see and preserve the nerves needed for sexual function. The goal is to improve men's recovery of sexual function one year after surgery. The study will involve 400 …

This study is testing if giving a common blood-thinning medication three times a day, instead of the usual two, provides more consistent protection against blood clots in high-risk pregnant women. Pregnancy increases the risk of clots, and current dosing often doesn't keep medica…

This study is testing a personalized approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Doctors will adjust the strength of the chemotherapy and radiation given before the transplant based on each patient's specific health and disease risk…

This study is testing if a shorter course of antibiotics is just as safe and effective as a longer one for treating severe, life-threatening flesh infections. It will compare giving antibiotics for 48 hours versus 7 days after surgery in 50 adult patients. The goal is to find the…

This study is testing whether levothyroxine, a common thyroid medication, can improve quality of life and heart health in people receiving dialysis. Researchers will give either the medication or a placebo to 336 dialysis patients with borderline thyroid levels for six months. Th…

This early-stage study is testing whether a new treatment using microscopic oxygen-filled bubbles can help wounds heal faster. Researchers will apply these bubbles in a dressing to wounds of 40 adult participants with various types of acute or chronic wounds. The main goal is to …

This study is testing a new version of a common weight loss surgery (sleeve gastrectomy) to see if it can better control severe acid reflux disease (GERD). Researchers will compare the new surgical technique to the standard one in 44 patients who already have GERD. They will meas…

This small, early-stage trial is testing if doctors can personalize chemotherapy for stomach cancer by using a special blood test to guide treatment. The goal is to see if adjusting the chemo based on how the cancer responds helps control the disease better before surgery. The st…

This is a small, early study to see if a special fluorescent dye called CYTALUX can help surgeons better see and remove cancerous spots during surgery for abdominal cancers that have spread. The dye is designed to stick to cancer cells and glow under special light. The main goal …

This study is testing two new, non-invasive imaging devices to help doctors better assess burn wound severity and predict healing potential. Researchers will use these light-based imaging techniques on burn patients of all ages to see if they can accurately determine which wounds…

This study is testing a new device that uses safe LED light to look inside the ear. The goal is to create a more accurate, objective way to diagnose middle ear infections, which are very common in children but can be tricky to diagnose correctly. Researchers will compare the devi…

This study is testing a comprehensive support program designed to prevent cervical cancer in women in India who have both HPV and HIV. The program provides group education, one-on-one support from a community health worker, nutritional guidance, and food supplements. Researchers …

This study is testing a coaching program called GRIT, designed to help teens who have experienced significant childhood stress. The goal is to teach them and their families better coping and self-regulation skills to prevent the early start of regular alcohol or cannabis use. Res…

This study is exploring whether sessions with a shamanic practitioner using drumming music can help reduce pain and other symptoms for people with fibromyalgia. Researchers will work with 25 female participants over 8 weeks, measuring pain levels, heart rate, breathing, and brain…

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study is testing whether real acupuncture can make opioid pain medication work better for people with fibromyalgia. Researchers will compare real acupuncture to fake acupuncture in 45 patients who already take daily opioids. The goal is to see if the real treatment improves …

This study aims to find the best dose of N-Acetylcysteine (N-AC), a common supplement, to help reduce symptoms in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. It will enroll 27 adults with ET, PV, or MF who have significant symptom burden. The main g…

This study is testing whether a complementary therapy called 'energy healing' can help reduce pain and fatigue for people with fibromyalgia. Researchers will compare real energy healing sessions to fake ones in 25 female participants to see if the real treatment changes brain act…

This study is testing whether music therapy is a practical way to help improve quality of life for teens and adults with sickle cell disease. Researchers will compare three different programs: in-person music therapy, a mix of in-person and virtual music therapy, and a standard h…

This study is testing whether nicotine gum can help reverse age-related difficulties in processing sounds, like understanding speech in noisy places. Researchers will give 48 non-smoking adults, both young and older, nicotine gum or a placebo during separate sessions to measure i…

This study is testing a short, 5-session therapy program designed to build resilience and coping skills in people recently released from prison on parole. The goal is to see if the program is practical and acceptable to participants and if it helps reduce adjustment difficulties …

This study is testing whether eating a light meal before a specific type of hand surgery can make patients feel better. It will compare two groups: one that eats before surgery and one that fasts. Researchers will measure anxiety, nausea, and overall satisfaction to see if eating…

This study compares two different drugs used to reverse muscle relaxants given during bowel surgery. Researchers want to see which drug helps patients have their first bowel movement and tolerate solid food sooner after surgery. The study involves 128 adults having laparoscopic b…

This study aims to better understand a common condition called Genitourinary Syndrome of Menopause (GSM), which causes vaginal dryness and discomfort. Researchers will use a special, non-invasive camera (OCT device) to take detailed pictures of vaginal tissue in 50 postmenopausal…

This study is testing new, non-invasive camera-based tools to see how well they can measure blood flow in the skin. Researchers will briefly restrict blood flow in participants' arms with a pressure cuff to see how the tools detect changes. The goal is to check if these imaging m…

This study aims to develop better ways to measure oral health using photographs and imaging software. Researchers will enroll 275 adults to test whether specific, common toothpastes and mouthwashes can improve gum health and reduce plaque over 7 days to 6 months. The main goal is…

This study aims to understand how ibogaine, a plant-derived compound, might change brain function in people with opioid use disorder. Researchers will use brain scans and surveys to measure changes in brain activity, chemistry, and cravings in 20 participants who are already sche…

This study aims to create better, safer ways to test exercise in children with chronic health conditions. Researchers will follow 240 children and teens with cystic fibrosis, sickle cell disease, or long-term effects from COVID-19 over several years. They will measure how their b…

This study aims to understand how blood vessel health is connected to erectile dysfunction (ED) and heart disease risk. Researchers will measure blood vessel function in men with ED before and after they start standard treatments like ED pills or testosterone therapy. The goal is…

This study is testing whether video calls (telemedicine) are a practical way to help people considering donating a kidney. Researchers want to see if remote education and counseling helps potential donors make more confident decisions. They will compare video visits to standard i…

This study aims to understand how two common over-the-counter mouthwashes affect the bacteria and viruses in your mouth and gut. Researchers will compare Listerine, Lumineux Oral Essentials, and plain water when used twice daily for about six months by 200 healthy young adults. T…

This study aims to understand if the types of bacteria in a person's gut are connected to how well their lung cancer treatment works and what side effects they experience. Researchers will collect stool samples from 82 adults with advanced lung cancer before they start treatment …

This study is testing a new way to collect blood for cancer detection. Researchers want to see if taking blood from a vein directly draining the cancer during a biopsy finds more tumor DNA than a standard blood draw from the arm. The goal is to improve the accuracy of blood tests…

This study aims to understand if a patient's personality is linked to how consistently they take their oral medication for chronic myeloid leukemia (CML). Researchers will recruit 75 people with CML who are on specific cancer drugs. Participants will answer questionnaires about t…

This study aims to understand the early brain changes that happen before noticeable memory problems begin. Researchers will use MRI and PET brain scans, along with memory tests, to track 300 older adults with normal thinking skills over time. The goal is to find the best combinat…