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Could blood from a cancer's own vein reveal more tumor DNA?

NCT ID NCT05497531

Recruiting now Knowledge-focused Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study compares two ways of collecting blood to detect circulating tumor DNA (ctDNA) in people with liver or pancreatic cancers. Researchers will take blood from a standard arm vein and also from the vein that drains directly from the tumor during a biopsy. The goal is to see if the tumor-draining vein sample contains more or different tumor DNA. Only 15 participants are being enrolled, so this is an early-stage exploration.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a more sensitive way to detect tumor DNA, potentially improving cancer monitoring and treatment decisions.
What could go wrong
This is a very small pilot study with only 15 participants, so results may not apply broadly. The procedure is also more invasive than a standard blood draw.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoma of the ampulla of vater cholangiocarcinoma exocrine pancreatic carcinoma hepatobiliary neoplasm hepatocellular carcinoma malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPULLARY CANCER CHOLANGIOCARCINOMA HEPATOBILIARY CANCER HEPATOCELLULAR CARCINOMA PANCREATIC CANCER PANCREATIC CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Chao Family Comprehensive Cancer Center, University of California, Irvine

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

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