New therapy aims to stop depression before it starts in At-Risk teens

NCT ID NCT06273137

Recruiting now Prevention Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a therapy called Positive Affect Treatment (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more adverse childhood events. The therapy involves 15 weekly sessions focused on building positive emotions and coping skills. Researchers will compare PAT to a waitlist or supportive therapy in up to 300 teens, measuring mood and reward sensitivity over a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Positive Affect Treatment (PAT) - a behavioral therapy with weekly sessions focusing on behaviors, cognitions, and compassion
What this could lead to: If successful, this could provide a new, non-drug way to prevent depression in teenagers who have faced difficult childhood experiences.
What could go wrong: This is an early-stage trial with a pilot phase and a larger phase. The therapy may not be more effective than standard supportive therapy, and results may not apply to all teens.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

University of California Irvine
RECRUITING

Irvine, California, 92617, United States

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