Mouthwash showdown: listerine vs. lumineux – which changes your microbiome?

NCT ID NCT05603650

Recruiting now Knowledge-focused Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how two over-the-counter mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three common viruses in the mouth and gut. Two hundred healthy adults aged 18-25 will rinse twice daily with one of the mouthwashes or water for about six months. Researchers will collect mouth swabs and stool samples to track changes in the microbiome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mouthrinse (Listerine or Lumineux Oral Essentials)
What this could lead to: If successful, this could reveal how common mouthwashes influence oral and gut health, potentially guiding better hygiene choices.
What could go wrong: This is an early-stage observational study with no direct treatment goal. Results may not lead to any health recommendations or clinical changes.

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Conditions

The condition(s) this trial relates to.

infectious disease viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MICROBIAL COLONIZATION ORAL BACTERIAL INFECTION ORAL INFECTION VIRAL INFECTION

Contacts and locations

Locations

Beckman Laser Institute and Medical Clinic
RECRUITING

Irvine, California, 92612, United States

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