Brain scans reveal Ibogaine's effects on opioid cravings

NCT ID NCT07226570

Recruiting now Knowledge-focused Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses brain scans (MRI, MRS, EEG) to see how ibogaine affects the brain in 20 people with moderate to severe opioid use disorder. Participants will already be receiving legal ibogaine treatment outside the U.S. The research team only observes and measures brain activity, cravings, and withdrawal symptoms before and after treatment. The goal is to understand how ibogaine might work in the brain, not to test if it is a safe or effective treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ibogaine
What this could lead to: If successful, this study could help explain how ibogaine affects the brain in opioid use disorder, potentially guiding future treatments.
What could go wrong: This is a very small observational study (20 people) where researchers do not provide the treatment. It cannot prove ibogaine works or is safe, only explore brain changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE DISORDER (OUD)

Contacts and locations

Locations

Susan Samueli Integrative Health Institute, University of California, Irvine
RECRUITING

Irvine, California, 92617, United States

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