Can a common antioxidant ease MPN symptoms?
NCT ID NCT05123365
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests N-Acetylcysteine (N-AC), an antioxidant, in 27 adults with myeloproliferative neoplasms (MPN) like essential thrombocythemia, polycythemia vera, or myelofibrosis. The goal is to find the best dose that safely reduces symptom burden, measured by a symptom score. Participants continue their usual MPN treatments while taking N-AC.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
N-Acetylcysteine (N-AC)
What this could lead to
If it works, this could point toward a well-tolerated way to reduce symptom burden for people with MPN.
What could go wrong
This is a small, early-phase study (27 people) focused on finding the right dose, not proving effectiveness. It may not lead to a new standard treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Chao Family Comprehensive Cancer Center, University of California, Irvine
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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University of California, Irvine
RECRUITINGIrvine, California, 92617, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••