University Of California, Irvine

This early-phase study tests whether a single dose of two immunotherapy drugs can increase cancer-fighting immune cells inside tumors. It includes 34 adults with untreated stomach or esophageal cancers that have not spread and carry a specific gene change called ARID1A. The goal …

This study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink melanoma tumors in adults with stage IIIB to IV melanoma that can be removed. About 35 participants will receive the drugs, then have surgery to remove any remaining cance…

This study tests a small change to a procedure called POEM, which helps people with achalasia (a swallowing disorder) eat more easily. The change aims to lower the common side effect of severe heartburn after the procedure. About 120 adults will be randomly assigned to get either…

This study tests whether using a quick, non-invasive bedside ultrasound (POCUS) to detect excess fluid in the lungs and veins can help doctors decide to give a diuretic (furosemide) to postpartum patients with preeclampsia. The goal is to see if this approach leads to faster bloo…

This study tests whether a supplement called N-Acetyl-Cysteine (NAC) can reduce memory and thinking problems caused by chemotherapy in ovarian cancer patients. About 102 women with advanced ovarian cancer will receive NAC alongside their standard platinum-based chemo. The goal is…

This study compares two ways to close small, simple cuts on the face: sticky strips (like Steri-Strips) and traditional stitches. The goal is to see which method causes less pain, leads to a better-looking scar, and makes patients happier. About 62 adults with small facial cuts w…

This study tests whether using a chatbot to guide communication can improve relationship satisfaction between parents and their children (ages 12-17). About 120 parent-child pairs in the US will try different communication methods, including a chatbot, and report how well they co…

This study looks at whether a short music mindfulness video can help lower pain in adults with neck or back pain while they wait in the emergency room. About 60 people will take part. Half will watch a video on using music for pain and then listen to jazz for 15 minutes. The othe…

This study explores whether generative AI can support people who are already in therapy for generalized anxiety disorder or major depressive disorder. Researchers will enroll 204 adults in the U.S. who are currently in individual therapy. Participants will use an AI tool alongsid…