University Of California, Irvine

This study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink melanoma tumors in people with stage IIIB to IV melanoma. About 35 adults will receive the drugs, then have surgery to remove any remaining cancer. The main goal is to see…

This early-phase trial is testing whether a single dose of two immunotherapy drugs (tremelimumab and durvalumab) can increase cancer-fighting immune cells inside tumors. It includes 34 people with untreated, non-metastatic stomach or esophageal cancers that have an ARID1A gene mu…

This study tests whether a quick bedside ultrasound can help doctors decide if new mothers with preeclampsia need a diuretic (water pill) to lower their blood pressure. About 96 postpartum patients will be enrolled. The goal is to see if this approach speeds up blood pressure rec…

This study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…

This phase 2 trial will test whether a special PET scan using Flotufolastat F18 can accurately detect any remaining prostate cancer after focal therapy (like cryotherapy or HIFU). About 60 men with prostate cancer who haven't had prior treatment will get the scan before and after…

This study tests whether an intelligent chatbot can help people quit smoking by joining their private online support groups. 120 adult smokers who are ready to quit within 10 days will be split into two groups: one with a chatbot that responds when no human does, and one with a s…

This study tests whether N-Acetyl-Cysteine (NAC), a supplement, can reduce chemotherapy-related cognitive impairment (often called 'chemo brain') in ovarian cancer patients. About 102 postmenopausal women with advanced ovarian cancer receiving platinum-based chemotherapy will tak…

This study tests whether using an AI chatbot like ChatGPT during arguments can improve parent-child relationships. About 120 parent-child pairs will either use the chatbot or take a break before discussing tough topics. Researchers will measure changes in communication and relati…

This study looks at whether using adhesive strips (like Steri-Strips) instead of traditional stitches leads to better results for small, simple cuts on the face. About 62 adults with facial cuts smaller than 2.5 cm will be randomly assigned to get either strips or stitches. The g…

This study will test whether teaching patients to mindfully listen to jazz music for 15 minutes can lower their pain while they wait in the emergency department. The researchers will enroll 60 adults with neck or back pain and compare the music approach to a standard mindful pain…

This study will test if using an AI chatbot like ChatGPT can help people with generalized anxiety disorder or major depressive disorder who are already in regular therapy. Researchers plan to recruit 204 adults in the U.S. who are currently in individual therapy. Participants wil…