Old HIV drug could help bone marrow make red blood cells
NCT ID NCT07281781
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether nelfinavir, a drug originally used for HIV, can help people with myelofibrosis who have anemia (low red blood cells). The drug aims to restore iron delivery to the bone marrow. Ten adults with myelofibrosis and low hemoglobin will take nelfinavir twice daily to see if their anemia improves and if fibrosis markers decrease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nelfinavir (an HIV drug being repurposed)
What this could lead to
If it works, this could offer a new way to treat anemia in myelofibrosis patients without needing blood transfusions.
What could go wrong
This is a very small early-phase trial with only 10 participants, so results may not apply broadly. The drug may not improve anemia or could cause side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Chao Family Comprehensive Cancer Center, University of California, Irvine
RECRUITINGOrange, California, 92868, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••