New combo therapy shows promise for Hard-to-Treat sarcomas

NCT ID NCT05488366

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 30 times

Summary

This early-phase study tested whether combining the immunotherapy drug pembrolizumab with precise, high-dose radiation (SBRT) is feasible for people with advanced soft-tissue sarcoma that has spread or cannot be removed by surgery. Nine participants received the combination. The main goal was to see if patients could complete the treatment, and researchers also measured how well the tumors responded, including at sites not directly treated with radiation.

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Contacts and locations

Locations

  • Chao Family Comprehensive Cancer Center, University of California, Irvine

    Orange, California, 92868, United States

Conditions

Explore the condition pages connected to this study.