Hospital study tests decolonization to stop superbug infections
NCT ID NCT01209234
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a 5-day decolonization routine using nasal ointment, mouth rinse, and body wash could prevent MRSA infections in over 2,000 adults carrying the bacteria after hospital discharge. Participants were randomly assigned to either the decolonization regimen or standard education about MRSA. The goal was to see if the routine reduced infections and re-hospitalizations compared to education alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mupirocin and chlorhexidine
- What this could lead to
- If successful, this approach could become a standard way to prevent dangerous MRSA infections in people carrying the bacteria, reducing hospital readmissions.
- What could go wrong
- The trial is completed, but results may show only modest benefit or be limited to certain patient groups. Decolonization may not work for everyone and could cause skin irritation or allergies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chapman Care Center
Garden Grove, California, 92840, United States
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Country Villa Plaza
Santa Ana, California, 92707, United States
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Covington Care Center
Aliso Viejo, California, 92656, United States
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Downey Regional Medical Center
Downey, California, 90241, United States
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Fountain Valley Regional Hospital & Medical Center
Fountain Valley, California, 92708, United States
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Harbor-UCLA Medical Center
Torrence, California, 90502, United States
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Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92658, United States
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Little Company of Mary - San Pedro
San Pedro, California, 90732, United States
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Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
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Mission Hospital
Mission Viejo, California, 92691, United States
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Orange Coast Memorial Medical Center
Fountain Valley, California, 92708, United States
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Pacific Haven HealthCare Center
Garden Grove, California, 92843, United States
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Providence Little Company of Mary Medical Center
Torrance, California, 90732, United States
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Regents Point at Windcrest
Irvine, California, 92612, United States
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Royale Healthcare
Santa Ana, California, 92707, United States
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Saddleback Memorial Medical Center - Laguna Hills
Laguna Hills, California, 92653, United States
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Saddleback Memorial Medical Center - San Clemente
San Clemente, California, 92673, United States
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St. Jude Medical Center
Fullerton, California, 92835, United States
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St. Mary Medical Center
Long Beach, California, 90813, United States
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Torrance Memorial Medical Center
Torrance, California, 90505, United States
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UC Irvine Medical Center
Orange, California, 92868, United States
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Ventura County Medical Center
Ventura, California, 93003, United States
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Villa Elena Health Care Center
Norwalk, California, 90650, United States
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West Anaheim Extended Care
Anaheim, California, 92804, United States
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