Hospital study tests decolonization to stop superbug infections

NCT ID NCT01209234

Completed Disease control Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a 5-day decolonization routine using nasal ointment, mouth rinse, and body wash could prevent MRSA infections in over 2,000 adults carrying the bacteria after hospital discharge. Participants were randomly assigned to either the decolonization regimen or standard education about MRSA. The goal was to see if the routine reduced infections and re-hospitalizations compared to education alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

mupirocin and chlorhexidine

What this could lead to

If successful, this approach could become a standard way to prevent dangerous MRSA infections in people carrying the bacteria, reducing hospital readmissions.

What could go wrong

The trial is completed, but results may show only modest benefit or be limited to certain patient groups. Decolonization may not work for everyone and could cause skin irritation or allergies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

methicillin-resistant staphylococcus aureus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

Contacts and locations

Show contact details

Locations

Chapman Care Center

Garden Grove, California, 92840, United States
Country Villa Plaza

Santa Ana, California, 92707, United States
Covington Care Center

Aliso Viejo, California, 92656, United States
Downey Regional Medical Center

Downey, California, 90241, United States
Fountain Valley Regional Hospital & Medical Center

Fountain Valley, California, 92708, United States
Harbor-UCLA Medical Center

Torrence, California, 90502, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92658, United States
Little Company of Mary - San Pedro

San Pedro, California, 90732, United States
Long Beach Memorial Medical Center

Long Beach, California, 90806, United States
Mission Hospital

Mission Viejo, California, 92691, United States
Orange Coast Memorial Medical Center

Fountain Valley, California, 92708, United States
Pacific Haven HealthCare Center

Garden Grove, California, 92843, United States
Providence Little Company of Mary Medical Center

Torrance, California, 90732, United States
Regents Point at Windcrest

Irvine, California, 92612, United States
Royale Healthcare

Santa Ana, California, 92707, United States
Saddleback Memorial Medical Center - Laguna Hills

Laguna Hills, California, 92653, United States
Saddleback Memorial Medical Center - San Clemente

San Clemente, California, 92673, United States
St. Jude Medical Center

Fullerton, California, 92835, United States
St. Mary Medical Center

Long Beach, California, 90813, United States
Torrance Memorial Medical Center

Torrance, California, 90505, United States
UC Irvine Medical Center

Orange, California, 92868, United States
Ventura County Medical Center

Ventura, California, 93003, United States
Villa Elena Health Care Center

Norwalk, California, 90650, United States
West Anaheim Extended Care

Anaheim, California, 92804, United States