Drug cocktail aims to shrink Hard-to-Treat stomach cancers
NCT ID NCT04164979
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether combining two drugs—cabozantinib and pembrolizumab—can slow or stop the growth of advanced gastric or gastroesophageal cancer. The study enrolls people whose cancer has worsened despite at least one prior chemotherapy treatment. Researchers will measure how many participants remain progression-free after six months and track any serious side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cabozantinib combined with pembrolizumab
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced gastric cancer who have run out of standard chemotherapy options.
- What could go wrong
- This is an early-phase, single-arm trial with only 34 participants, so results may not be definitive. Combining two drugs also raises the risk of serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Chao Family Comprehensive Cancer Center, University of California, Irvine
Orange, California, 92868, United States
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