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Tailored chemo shows promise for stomach cancer in early trial

NCT ID NCT05733689

Recruiting now Disease control Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether adjusting chemotherapy based on how a patient's tumor responds can improve outcomes for people with stomach or gastroesophageal junction cancer. About 20 participants with stage IB to III disease will receive standard chemo combinations (FLOT, FOLFOX, or FOLFIRI), and their treatment plan may be changed based on tumor response. The main goal is to see if this personalized approach helps more patients complete their planned treatment and proceed to curative surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
chemotherapy combinations (FLOT, FOLFOX, FOLFIRI)
What this could lead to
If successful, this could show that tailoring chemotherapy based on early response helps more patients complete treatment and have successful surgery.
What could go wrong
This is a very early phase 1 trial with only 20 people, so results may not apply widely. The chemotherapy combinations have known side effects like nerve damage, low blood counts, and digestive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Chao Family Comprehensive Cancer Center, University

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

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