New pill targets Hard-to-Treat cancers in early trial

NCT ID NCT06244771

Recruiting now Disease control Sponsor: Frontier Medicines Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental oral drug called FMC-376 in people with advanced solid tumors (like lung, colorectal, or pancreatic cancer) that have a specific genetic change called KRAS G12C. The trial has three parts: first, finding the safest dose; then, checking how well the drug works in different cancer types. About 403 participants will take daily capsules, and researchers will monitor side effects, drug levels in the blood, and tumor response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FMC-376 (oral capsule)
What this could lead to: If successful, this could lead to a new treatment option for people with advanced solid tumors that have a specific KRAS G12C mutation, potentially shrinking tumors or slowing their growth.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not work as hoped or could cause unexpected side effects. It is not yet proven to be safe or effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm lung neoplasm malignant pancreatic neoplasm metastatic malignant neoplasm Neoplasm Metastasis non-small cell lung carcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS WITH KRAS G12C MUTATIONS COLORECTAL CANCER KRAS G12C METASTATIC SOLID TUMOR NON-SMALL CELL LUNG CANCER PANCREATIC CANCER SOLID TUMOR, ADULT UNRESECTABLE SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Community Clinical Trials
COMPLETED

Kingwood, Texas, 77339, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Eastern Health - Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Florida Cancer Specialists and Research Institute
COMPLETED

Lake Mary, Florida, 32746, United States
GenesisCare North Adelaide
RECRUITING

North Adelaide, South Australia, 5006, Australia

Contact Email: •••••@•••••
Icon Cancer Centre Kurralta Park
RECRUITING

Kurralta Park, South Australia, 5037, Australia

Contact Email: •••••@•••••
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Korea University Anam Hospital
RECRUITING

Seoul, Seongbuk-gu, 02841, South Korea
Linear Clinical Research Ltd
RECRUITING

Nedlands, Western Australia, 6009, Australia
Macquarie University
RECRUITING

Macquarie Park, New South Wales, 2109, Australia

Contact Email: •••••@•••••
Northwest Cancer Centers
RECRUITING

Dyer, Indiana, 46311, United States
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
Seoul National University Bundang Hospital
RECRUITING

Gyeonggi-do, Seongnam-si, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Jongno-gu, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, Seodaemun-gu, 03722, South Korea
South Texas Accelerated Research Therapeutics, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Tasman Health Care
RECRUITING

Southport, Queensland, 4215, Australia

Contact Email: •••••@•••••
The Catholic University of Korea, St. Vincent's Hospital
RECRUITING

Gyeonggi-do, Suwon-si, 16247, South Korea
The University of Kansas Cancer Center
RECRUITING

Fairway, Kansas, 66205, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UT Health San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of California Irvine (UCI) - Chao Family Comprehensive Cancer Center
COMPLETED

Orange, California, 92868, United States
University of California San Diego (UC San Diego) Health - Jacobs Medical Center - Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
University of California San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94158, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States

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