New targeted drug hopes to shrink Hard-to-Treat cancers
NCT ID NCT06244771
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 32 times
Summary
This study tests an experimental drug called FMC-376 in people with advanced solid tumors that have a specific genetic change (KRAS G12C). The goal is to find a safe dose and see if the drug can shrink tumors. About 400 adults whose cancer has worsened after standard treatments will take part.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Community Clinical Trials
COMPLETEDKingwood, Texas, 77339, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Eastern Health - Box Hill Hospital
RECRUITINGBox Hill, Victoria, 3128, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Florida Cancer Specialists and Research Institute
COMPLETEDLake Mary, Florida, 32746, United States
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GenesisCare North Adelaide
RECRUITINGNorth Adelaide, South Australia, 5006, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Icon Cancer Centre Kurralta Park
RECRUITINGKurralta Park, South Australia, 5037, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Karmanos Cancer Institute
RECRUITINGDetroit, Michigan, 48201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Korea University Anam Hospital
RECRUITINGSeoul, Seongbuk-gu, 02841, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Linear Clinical Research Ltd
RECRUITINGNedlands, Western Australia, 6009, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Macquarie University
RECRUITINGMacquarie Park, New South Wales, 2109, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwest Cancer Centers
RECRUITINGDyer, Indiana, 46311, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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START Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seoul National University Bundang Hospital
RECRUITINGGyeonggi-do, Seongnam-si, 13620, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seoul National University Hospital
RECRUITINGSeoul, Jongno-gu, 03080, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Severance Hospital
RECRUITINGSeoul, Seodaemun-gu, 03722, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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South Texas Accelerated Research Therapeutics, LLC
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tasman Health Care
RECRUITINGSouthport, Queensland, 4215, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Catholic University of Korea, St. Vincent's Hospital
RECRUITINGGyeonggi-do, Suwon-si, 16247, South Korea
Contact Phone: •••-•••-••••
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The University of Kansas Cancer Center
RECRUITINGFairway, Kansas, 66205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UT Health San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Irvine (UCI) - Chao Family Comprehensive Cancer Center
COMPLETEDOrange, California, 92868, United States
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University of California San Diego (UC San Diego) Health - Jacobs Medical Center - Moores Cancer Center
RECRUITINGLa Jolla, California, 92037, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center
RECRUITINGSan Francisco, California, 94158, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.