New pill targets hard-to-treat cancers with KRAS G12D mutation

NCT ID NCT07020221

Recruiting now Disease control Sponsor: Verastem, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new daily pill, VS-7375, in people with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific KRAS G12D mutation. The goal is to see if the drug is safe and can shrink tumors when used alone or with other cancer treatments. About 295 adults will take part across multiple groups.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm digestive system neoplasm lung neoplasm Neoplasm Metastasis non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER G12D MUTATED KRAS NON-SMALL CELL LUNG CANCER PANCREATIC DUCTAL ADENOCARCINOMA SOLID TUMOR, ADULT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Peninsula and Southeast Oncology
RECRUITING

Frankston, Victoria, 3199, Australia
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Univ of Pennsylvania, Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Email: •••••@•••••
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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