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New enzyme shot takes aim at Hard-to-Treat tumors

NCT ID NCT07339176

Recruiting now Disease control Sponsor: Onchilles Pharma Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This trial tests a new drug called N17350, a modified enzyme injected directly into tumors, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find the safest and most effective dose, and to see if the drug can shrink or stop tumor growth. Participants will receive injections every two weeks for up to 12 weeks, along with regular checkups and scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
N17350 (a modified enzyme injected directly into tumors)
What this could lead to
If it works, this could offer a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong
This is an early-phase trial (Phase 1/2) with a small number of participants, so the treatment may not shrink tumors or may cause side effects. Success is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck neoplasm Head and Neck Neoplasms melanoma neoplasm Neoplasm Metastasis non-small cell lung carcinoma skin squamous cell carcinoma squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST NEOPLASMS, TRIPLE-NEGATIVE CARCINOMA, NON-SMALL-CELL LUNG CARCINOMA, SQUAMOUS CELL HEAD AND NECK NEOPLASMS MELANOMA NEOPLASMS, SOLID TUMOR SQUAMOUS CELL CARCINOMA OF SKIN

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Calvary Mater Hospital

    RECRUITING

    Newcastle, New South Wales, 2298, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Roswell Park Comprehensive Cancer Center

    RECRUITING

    Buffalo, New York, 14263, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Angeles Clinic and Research Institute

    NOT_YET_RECRUITING

    Los Angeles, California, 90025, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UCLA - Jonsson Comprehensive Cancer Center

    NOT_YET_RECRUITING

    Los Angeles, California, 90095, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California, San Francisco

    NOT_YET_RECRUITING

    San Francisco, California, 94143, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Westmead Hospital

    RECRUITING

    Westmead, New South Wales, 2145, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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