New combo therapy aims to tackle melanoma that resists treatment
NCT ID NCT06906822
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial is testing whether a combination of two drugs, enfortumab vedotin and pembrolizumab, can shrink tumors in people with advanced melanoma that has worsened after standard therapy. The study will enroll 60 adults with unresectable stage III or IV melanoma. Researchers hope that targeting a protein called Nectin4 on melanoma cells may provide a new way to control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
enfortumab vedotin and pembrolizumab
What this could lead to
If successful, this combination could offer a new treatment option for advanced melanoma patients who have stopped responding to standard immunotherapy.
What could go wrong
This is an early phase 2 trial with only 60 participants, so results may not apply to all patients. The combination may cause side effects and might not improve outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Complexo Hospitalario Universitario de A Coruña
RECRUITINGA Coruña, A Coruña, 15006, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hospital Clinic de Barcelona
RECRUITINGBarcelona, Barcelona, 08036, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITINGMurcia, Murcia, 30120, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital General de Valencia
RECRUITINGValencia, Valencia, 46014, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari Dexeus
NOT_YET_RECRUITINGBarcelona, Barcelona, 08028, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Madrid, 28041, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario La Paz
RECRUITINGMadrid, Madrid, 28046, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Marqués de Valdecilla
RECRUITINGSantander, Cantabria, 39008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Miguel Servet
RECRUITINGZaragoza, Zaragoza, 50009, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Madrid, 28034, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Valle de Hebrón
RECRUITINGBarcelona, Barcelona, 08035, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Virgen del Rocío
RECRUITINGSeville, Sevilla, 41013, Spain
Contact Email: •••••@•••••
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Institut Català D'Oncologia - Badalona
RECRUITINGBadalona, Barcelona, 08916, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact