Could removing just one lymph node stop melanoma from coming back?
NCT ID NCT05839912
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study is testing whether removing only the cancerous lymph node in people with stage III melanoma can prevent the cancer from returning in that same area. Participants have one detectable cancerous lymph node and will undergo surgery to remove it, with or without additional therapy before or after. The trial will also track side effects like swelling and how the surgery affects quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
surgical removal of a cancerous lymph node
What this could lead to
If successful, this could show that a less extensive surgery is enough to control melanoma in the lymph node area, reducing the need for more invasive procedures.
What could go wrong
This is a small, early-phase trial with only 66 participants, so results may not apply to everyone. The cancer could still return in the same area or spread elsewhere.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cancer Center at the University of Virginia
RECRUITINGCharlottesville, Virginia, 22908, United States
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Duke University Health System
RECRUITINGDurham, North Carolina, 27710, United States
Contact Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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University of Maryland
NOT_YET_RECRUITINGBaltimore, Maryland, 21201, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States