New study to reveal if modern melanoma drugs harm fertility

NCT ID NCT07092670

Recruiting now Knowledge-focused Sponsor: Intergruppo Melanoma Italiano Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study follows 270 women under 40 who have had melanoma removed and are now taking adjuvant therapies like dabrafenib, trametinib, pembrolizumab, or nivolumab. Researchers will measure ovarian reserve using a blood test before and after treatment to see how these drugs affect fertility. The goal is to help doctors and patients decide whether to pursue fertility preservation before starting treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better understand which melanoma treatments affect fertility and guide women on whether to consider egg freezing before starting therapy.
What could go wrong: This is an observational study, not a treatment trial. It will not test new drugs or change outcomes. Results may take years and may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infertility disorder melanoma skin neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FERTILITY MELANOMA

Contacts and locations

Locations

Azienda Ospedaliera Santa Maria della Misericordia - Unità di Oncologia Medica.
RECRUITING

Perugia, 06132, Italy
Azienda Ospedaliero-Universitaria, Modena
NOT_YET_RECRUITING

Modena, 41125, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
NOT_YET_RECRUITING

Milan, 20861, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
NOT_YET_RECRUITING

Roma, 00168, Italy
IOV Istituto Oncologico Veneto
NOT_YET_RECRUITING

Padova, 35128, Italy
IRCCS Ospedale Policlinico San Martino, Oncologia Medica 2
NOT_YET_RECRUITING

Genova, Italy
Istituto Nazionale Tumori "Fondazione Pascale"
NOT_YET_RECRUITING

Naples, 80016, Italy
Ospedale Oncologico "Giovanni Paolo II"
NOT_YET_RECRUITING

Bari, 70122, Italy
Università degli Studi di Siena - U.O.C. Immunoterapia Oncologica Azienda Ospedaliera Universitaria Senese
NOT_YET_RECRUITING

Siena, 53035, Italy
Università di Torino - Clinica Dermatologica
NOT_YET_RECRUITING

Torino, 10126, Italy

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