New hope for colorectal cancer: drug may stop return after surgery

NCT ID NCT04457297

Completed Disease control Sponsor: National Cancer Center Hospital East Source: ClinicalTrials.gov ↗

First seen Jan 22, 2026 · Last updated May 14, 2026 · Updated 15 times

Summary

This study tested whether a chemotherapy drug called FTD/TPI can prevent colorectal cancer from coming back in patients who had surgery to remove their tumors but still have cancer DNA in their blood. 243 patients were randomly assigned to receive either the drug or a placebo. The goal was to see if the drug could extend the time before the cancer returned or a new cancer appeared.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Aichi Cancer Center Hospital

Nagoya, Aichi-ken, 464-8681, Japan
Aizawa Hospital

Matsumoto, Nagano, 390-8510, Japan
Cancer Institute Hospital Of JFCR

Koto, Tokyo, 135-8550, Japan
Chiba Cancer Center

Chiba, Chiba, 260-8717, Japan
Gifu University Hospital

Gifu, Gifu, 501-1194, Japan
Hiroshima University Hospital

Hiroshima, Hiroshima, 734-8551, Japan
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Hospital of the University of Occupational and Environmental Health

Kitakyushu, Fukuoka, 807-8556, Japan
Kagawa University Hospital

Kita, Kagawa-ken, 761-0793, Japan
Kanagawa Cancer Center

Yokohama, Kanagawa, 241-8515, Japan
Kanazawa University Hospital

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kansai Medical University Hospital

Hirakata, Osaka, 573-1191, Japan
Kumamoto University Hospital

Kumamoto, Kumamoto, 860-8556, Japan
Kyorin University Hospital

Mitaka, Tokyo, 181-8611, Japan
Kyoto-Katsura Hospital

Kyoto, Kyoto, 615-8256, Japan
Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582, Japan
National Cancer Center Hospital

Chūō, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, 811-1395, Japan
National Hospital Organization Osaka National Hospital

Osaka, Osaka, 540-0006, Japan
National Taiwan University Hospital

Taipei, Taiwan, 100229, Taiwan
Okayama University Hospital

Okayama, Okayama-ken, 700-8558, Japan
Osaka Medical and Pharmaceutical University Hospital

Takatsuki, Osaka, 569-8686, Japan
Osaka University Hospital

Suita, Osaka, 565-0871, Japan
Saitama Cancer Center

Saitama, Saitama, 362-0806, Japan
Sano Hospital

Kobe, Hyōgo, 655-0031, Japan
Sapporo Medical University Hospital

Sapporo, Hokkaido, 060-8543, Japan
Shikoku Cancer Center

Matsuyama, Ehime, 791-0280, Japan
Shimane Prefectural Central Hospital

Izumo, Shimane, 693-8555, Japan
Shizuoka Cancer Center

Shizuoka, Shizuoka, 411-8777, Japan
St. Marianna University School of Medicine Hospital

Kawasaki, Kanagawa, 216-8511, Japan
Tohoku University Hospital

Sendai, Miyagi, 980-8574, Japan
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Bunkyo, Tokyo, 113-8677, Japan
Toyama University Hospital

Toyama, Toyama, 930-0194, Japan
University Hospital, Kyoto Prefectural Univercity of Medicine

Kyoto, Kyoto, 602-8566, Japan
University of Fukui Hospital

Yoshida, Fukui, 910-1193, Japan
University of Tsukuba Hospital

Tsukuba, Ibaraki, 305-8576, Japan
University of the Ryukyus Hospital

Nakagami, Okinawa, 903-0215, Japan
Yokohama City University Medical Center

Yokohama, Kanagawa, 232-0024, Japan

Conditions

Explore the condition pages connected to this study.

CIRCULATING TUMOR DNA COLORECTAL NEOPLASMS TRIFLURIDINE AND TIPIRACIL