Brain zaps may rewire Smokers' reward centers

NCT ID NCT05766254

Recruiting now Knowledge-focused Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a non-invasive brain stimulation technique called TMS can change how the brain processes rewards in smokers. Researchers will compare different targeting methods to see which best boosts brain signals related to reward and decision-making. The goal is to find the optimal spot to stimulate, which could eventually help reduce cravings and support quitting. Thirty-six nicotine-dependent adults will participate in three sessions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS) device
What this could lead to: If successful, this could identify the best brain target for TMS to reduce cravings and improve decision-making in smokers, pointing toward better addiction treatments.
What could go wrong: This is a small, early-phase study with only 36 participants, focused on brain activity measures rather than quitting smoking. Results may not lead to a practical treatment.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE USE DISORDER

Contacts and locations

Locations

Rutgers University - Newark
RECRUITING

Newark, New Jersey, 07102, United States

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