E-Cig coolants may boost appeal – study investigates

NCT ID NCT05932745

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how cooling ingredients like WS-3 and menthol in e-cigarettes affect how much people like them and find them addictive. Researchers will have 66 adult e-cigarette users try different e-liquid mixtures and report their feelings of liking, craving, and harshness. The goal is to understand which components make e-cigarettes more appealing, which could guide future regulations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: E-liquid coolants (WS-3, WS-23, menthol)
What this could lead to: If successful, this study could help understand which e-cigarette ingredients make them more appealing or addictive, potentially informing future regulations.
What could go wrong: This is a small, early-stage study (66 participants) measuring subjective responses, not health outcomes. Results may not apply to all users or predict long-term addiction risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE USE DISORDER

Contacts and locations

Locations

JB Pierce Lab
RECRUITING

New Haven, Connecticut, 06519, United States

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